SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3f5x CYCLIN-A2
(Homo
sapiens) 		5 / 11 LEU B 262
LEU B 263
ALA B 264
ILE B 281
LEU B 227
 None
 1.28A 1g50A-3f5xB:
undetectable		 1g50A-3f5xB:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3f5x CYCLIN-A2
(Homo
sapiens) 		4 / 7 LEU B 253
VAL B 256
GLY B 257
ASP B 240
 None
 0.70A 1t88A-3f5xB:
undetectable		 1t88A-3f5xB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3f5x CYCLIN-A2
(Homo
sapiens) 		4 / 8 LEU B 253
VAL B 256
GLY B 257
ASP B 240
 None
 0.51A 2a1oA-3f5xB:
undetectable		 2a1oA-3f5xB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3f5x CYCLIN-A2
(Homo
sapiens) 		3 / 3 TRP B 217
THR B 285
TYR B 286
 None
 0.69A 2a3aA-3f5xB:
undetectable		 2a3aA-3f5xB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3f5x CYCLIN-A2
(Homo
sapiens) 		3 / 3 TRP B 217
THR B 285
TYR B 286
 None
 0.64A 2a3aB-3f5xB:
undetectable		 2a3aB-3f5xB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3f5x CYCLIN-A2
(Homo
sapiens) 		3 / 3 TRP B 217
THR B 285
TYR B 286
 None
 0.71A 2a3bA-3f5xB:
undetectable		 2a3bA-3f5xB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3f5x CYCLIN-A2
(Homo
sapiens) 		5 / 11 LEU B 336
LEU B 394
LEU B 339
HIS B 404
PRO B 346
 None
 1.40A 2x7hA-3f5xB:
undetectable
2x7hB-3f5xB:
undetectable		 2x7hA-3f5xB:
22.81
2x7hB-3f5xB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3f5x CYCLIN-A2
(Homo
sapiens) 		5 / 12 LEU B 384
LEU B 430
GLY B 357
ALA B 358
LEU B 362
 None
 1.08A 3nt1B-3f5xB:
undetectable		 3nt1B-3f5xB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3f5x CYCLIN-A2
(Homo
sapiens) 		4 / 6 LEU B 430
CYH B 390
HIS B 395
LEU B 394
 None
 1.37A 5hrqD-3f5xB:
undetectable
5hrqG-3f5xB:
undetectable
5hrqH-3f5xB:
undetectable		 5hrqD-3f5xB:
7.51
5hrqG-3f5xB:
7.34
5hrqH-3f5xB:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 3f5x CYCLIN-A2
(Homo
sapiens) 		4 / 4 PRO B 195
LEU B 348
VAL B 236
ARG B 241
 None
 1.26A 6fgdA-3f5xB:
undetectable		 6fgdA-3f5xB:
21.83