SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 12 ILE A 158
ALA A 162
LEU A  16
ILE A  69
LEU A  73
 None
 1.28A 2zzaA-3f6fA:
undetectable		 2zzaA-3f6fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 11 ILE A 158
ALA A 162
LEU A  16
ILE A  69
LEU A  73
 None
 1.27A 2zzaB-3f6fA:
undetectable		 2zzaB-3f6fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 12 SER A  66
PHE A 118
ILE A 117
LEU A 161
ASP A 101
 None
 1.38A 3aocC-3f6fA:
undetectable		 3aocC-3f6fA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		4 / 8 SER A  66
ARG A  67
ALA A  10
THR A 166
 None
 0.92A 3bpxA-3f6fA:
2.1
3bpxB-3f6fA:
undetectable		 3bpxA-3f6fA:
19.43
3bpxB-3f6fA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 8 LEU A  98
ASP A 101
ALA A 159
SER A  14
SER A  66
 None
 1.40A 3rodA-3f6fA:
undetectable		 3rodA-3f6fA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 9 LEU A  98
ASP A 101
ALA A 159
SER A  14
SER A  66
 None
 1.48A 3rodB-3f6fA:
undetectable		 3rodB-3f6fA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		3 / 3 ASP A 157
TYR A 153
TRP A 183
 None
 1.31A 4p7nA-3f6fA:
undetectable		 4p7nA-3f6fA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 11 ILE A 158
ALA A 162
LEU A  16
ILE A  69
LEU A  73
 None
 1.17A 4qleB-3f6fA:
undetectable		 4qleB-3f6fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 11 ILE A 158
ALA A 162
LEU A  16
ILE A  69
LEU A  73
 None
 1.19A 4qlfA-3f6fA:
undetectable		 4qlfA-3f6fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 12 ILE A 158
ALA A 162
LEU A  16
ILE A  69
LEU A  73
 None
 1.17A 4qlgA-3f6fA:
undetectable		 4qlgA-3f6fA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		4 / 7 ASN A 127
GLU A 126
GLU A 125
TYR A 128
 None
 1.10A 4r87I-3f6fA:
undetectable		 4r87I-3f6fA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		5 / 12 ILE A 158
ALA A 162
LEU A  16
ILE A  69
LEU A  73
 None
 1.19A 4rgcA-3f6fA:
undetectable		 4rgcA-3f6fA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3f6f CG18548-PA
(IP02196P)
(IP02193P)
(Drosophila
melanogaster) 		4 / 6 PHE A 137
SER A 165
VAL A 164
ASP A 101
 None
 1.25A 5hesA-3f6fA:
undetectable		 5hesA-3f6fA:
21.86