SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE
(Leptospira
interrogans) 		5 / 12 GLY B 428
GLY B 426
ILE B 399
ALA B 409
TYR B 430
 None
 0.87A 1ri4A-3f6gB:
undetectable		 1ri4A-3f6gB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE
(Leptospira
interrogans) 		5 / 11 GLY B 445
ILE B 446
SER B 447
ILE B 448
LEU B 437
 None
 0.76A 2kawA-3f6gB:
undetectable		 2kawA-3f6gB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE
(Leptospira
interrogans) 		5 / 10 ALA B 436
LEU B 413
ILE B 446
LEU B 511
ILE B 448
 None
 1.17A 3jw3A-3f6gB:
undetectable		 3jw3A-3f6gB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE
(Leptospira
interrogans) 		6 / 12 ILE B 448
ALA B 499
THR B 496
ILE B 399
ALA B 409
GLU B 422
 None
 1.47A 5vceA-3f6gB:
undetectable		 5vceA-3f6gB:
16.06