SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 10 LEU A 183
LEU A 189
ILE A 244
THR A 304
ILE A 280
 None
 1.42A 1i18A-3f6tA:
undetectable
1i18B-3f6tA:
undetectable		 1i18A-3f6tA:
10.84
1i18B-3f6tA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 5 ASP A  96
LEU A  90
ALA A  52
LEU A  48
 None
 1.06A 1nh8A-3f6tA:
undetectable		 1nh8A-3f6tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 7 VAL A 500
VAL A 517
LEU A 518
LEU A 498
 None
 0.63A 1pthA-3f6tA:
undetectable		 1pthA-3f6tA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 7 VAL A 500
VAL A 517
LEU A 518
LEU A 498
 None
 0.63A 1pthB-3f6tA:
undetectable		 1pthB-3f6tA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		3 / 3 PHE A 100
ARG A  83
ASN A 106
 None
EDO  A 534 (-4.1A)
None
 0.89A 1xzxX-3f6tA:
undetectable		 1xzxX-3f6tA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		3 / 3 LYS A 156
ASP A 412
ASN A 403
 None
 0.99A 2bm9A-3f6tA:
2.9		 2bm9A-3f6tA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 GLY A 172
THR A 173
ALA A 174
ALA A 175
 LLP  A 312 ( 3.5A)
LLP  A 312 ( 3.6A)
None
None
 0.51A 2ej3A-3f6tA:
undetectable		 2ej3A-3f6tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 GLY A 172
THR A 173
ALA A 174
ALA A 175
 LLP  A 312 ( 3.5A)
LLP  A 312 ( 3.6A)
None
None
 0.53A 2ej3C-3f6tA:
undetectable		 2ej3C-3f6tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		6 / 12 SER A 311
SER A 309
ASN A  41
THR A 396
ALA A 288
VAL A 418
 LLP  A 312 ( 2.6A)
LLP  A 312 ( 2.5A)
None
None
None
None
 1.49A 2nniA-3f6tA:
undetectable		 2nniA-3f6tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 SER A 309
PHE A 314
LEU A 166
ILE A 146
SER A 394
 LLP  A 312 ( 2.5A)
None
None
None
None
 1.32A 2xrlA-3f6tA:
2.0		 2xrlA-3f6tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		3 / 3 GLU A 143
VAL A 140
CYH A 138
 None
 1.08A 3fbxA-3f6tA:
undetectable		 3fbxA-3f6tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 11 LEU A 153
ALA A 414
LEU A  48
GLN A  46
PHE A 314
 None
 1.36A 3jwqA-3f6tA:
undetectable
3jwqD-3f6tA:
undetectable		 3jwqA-3f6tA:
22.16
3jwqD-3f6tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		3 / 3 ASP A 370
ARG A 366
ALA A 369
 EDO  A 536 (-4.7A)
None
None
 0.64A 3mbgC-3f6tA:
undetectable		 3mbgC-3f6tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 VAL A 489
VAL A 517
LEU A 518
LEU A 477
LEU A 498
 None
 0.97A 3n8wA-3f6tA:
1.5		 3n8wA-3f6tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 VAL A 489
VAL A 517
LEU A 518
LEU A 477
LEU A 498
 None
 1.05A 3n8zA-3f6tA:
2.2		 3n8zA-3f6tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 TYR A 510
ILE A 513
VAL A 489
ILE A 446
 None
 0.79A 3p4wC-3f6tA:
undetectable		 3p4wC-3f6tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		3 / 3 GLU A  97
ASP A  96
ASP A  91
 None
 0.80A 4gc9A-3f6tA:
undetectable		 4gc9A-3f6tA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 6 ILE A 388
THR A 142
VAL A  54
ASP A  98
 None
 1.02A 4iaqA-3f6tA:
undetectable		 4iaqA-3f6tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 MET A 305
LEU A 247
ALA A 246
ILE A 176
LEU A 183
 None
 1.19A 4j24D-3f6tA:
undetectable		 4j24D-3f6tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 5 LYS A 238
LEU A 239
GLU A 235
LEU A 221
 None
 1.07A 4k4yA-3f6tA:
undetectable		 4k4yA-3f6tA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 5 LYS A 238
LEU A 239
GLU A 235
LEU A 221
 None
 1.09A 4k4yI-3f6tA:
undetectable		 4k4yI-3f6tA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		3 / 3 TRP A 123
GLN A 386
THR A 142
 None
 1.00A 4m2xA-3f6tA:
1.5		 4m2xA-3f6tA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 11 MET A 305
LEU A 247
ALA A 246
ILE A 176
LEU A 183
 None
 1.17A 4pxmB-3f6tA:
undetectable		 4pxmB-3f6tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 7 PHE A  87
LEU A  86
VAL A 105
PHE A 100
 None
 0.94A 4wnvD-3f6tA:
undetectable		 4wnvD-3f6tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 6 LYS A 329
ASP A 165
TYR A 302
TYR A 297
 None
 1.06A 5bmvB-3f6tA:
undetectable		 5bmvB-3f6tA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 ASP A 261
SER A 223
PHE A 260
ASN A 251
VAL A 249
 None
 1.28A 5d0yA-3f6tA:
undetectable		 5d0yA-3f6tA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 ASP A 261
SER A 223
PHE A 260
ASN A 251
VAL A 249
 None
 1.28A 5d0yB-3f6tA:
0.0		 5d0yB-3f6tA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 ALA A 264
LEU A 306
ILE A 146
GLY A 322
PHE A 293
 None
 1.17A 5fsaA-3f6tA:
undetectable		 5fsaA-3f6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 MET A 305
LEU A 247
ALA A 246
ILE A 176
LEU A 183
 None
 1.17A 5gs4A-3f6tA:
undetectable		 5gs4A-3f6tA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 8 ILE A 411
ASP A 412
GLY A 405
THR A 402
ASN A 292
 None
 1.25A 5hwaA-3f6tA:
undetectable		 5hwaA-3f6tA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 TYR A 510
ILE A 513
VAL A 489
ILE A 446
 None
 0.76A 5mzrE-3f6tA:
undetectable		 5mzrE-3f6tA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 SER A 444
PHE A  34
LEU A 505
LEU A 425
TYR A 510
 None
 1.26A 5y2oA-3f6tA:
undetectable		 5y2oA-3f6tA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 4 PHE A 473
ASP A 472
LEU A 477
LYS A 476
 None
 1.32A 6awvA-3f6tA:
undetectable		 6awvA-3f6tA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 10 MET A 305
LEU A 247
ALA A 246
ILE A 176
LEU A 183
 None
 1.17A 6cbzB-3f6tA:
undetectable		 6cbzB-3f6tA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 GLY A 315
THR A 317
PHE A 289
TYR A 286
 LLP  A 312 ( 4.6A)
None
LLP  A 312 ( 4.9A)
LLP  A 312 ( 4.6A)
 0.92A 6eqpA-3f6tA:
undetectable		 6eqpA-3f6tA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 11 THR A 304
VAL A 299
PHE A 260
ILE A 197
VAL A 249
 None
 1.30A 6hcoA-3f6tA:
undetectable
6hcoB-3f6tA:
1.2		 6hcoA-3f6tA:
23.75
6hcoB-3f6tA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 7 VAL A 105
ILE A 145
GLY A 315
ALA A  49
 None
None
LLP  A 312 ( 4.6A)
None
 0.83A 6hd6B-3f6tA:
undetectable		 6hd6B-3f6tA:
9.18