SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 8 HIS H  57
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.73A 1aq7A-3f6uH:
34.3
1aq7A-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
7 / 9 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.37A 1bcuH-3f6uH:
36.4
1bcuH-3f6uH:
40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 9 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
0.54A 1dwcH-3f6uH:
36.1
1dwcH-3f6uH:
40.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 8 ALA H  44
LEU H  33
LEU H  40
LEU H  68
None
0.94A 1ereE-3f6uH:
undetectable
1ereE-3f6uH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 8 ALA H  44
LEU H  33
LEU H  40
LEU H  68
None
0.95A 1ereF-3f6uH:
undetectable
1ereF-3f6uH:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
7 / 12 ASP H 189
GLU H 192
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 ( 4.0A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.66A 1etrH-3f6uH:
35.2
1etrH-3f6uH:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
7 / 12 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.67A 1etrH-3f6uH:
35.2
1etrH-3f6uH:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 8 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.49A 1f5lA-3f6uH:
33.1
1f5lA-3f6uH:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo
sapiens)
4 / 4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
None
1.25A 1hrkB-3f6uL:
undetectable
1hrkB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 5 VAL H 138
THR H 139
GLN H  30
ILE H 121
None
1.32A 1ss4A-3f6uH:
undetectable
1ss4A-3f6uH:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 6 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.40A 1tnlA-3f6uH:
35.2
1tnlA-3f6uH:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 12 GLY H 193
SER H 195
LEU H  40
LEU H  64
HIS H  57
0G6  H   1 (-4.1A)
0G6  H   1 (-1.8A)
None
None
0G6  H   1 (-3.2A)
0.94A 1ya4C-3f6uH:
undetectable
1ya4C-3f6uH:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 6 THR H  22
SER H  27
ASP H  26
VAL H 200
None
1.18A 2hdnI-3f6uH:
undetectable
2hdnJ-3f6uH:
undetectable
2hdnL-3f6uH:
undetectable
2hdnI-3f6uH:
9.21
2hdnJ-3f6uH:
20.81
2hdnL-3f6uH:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 6 VAL H 200
THR H  22
SER H  27
ASP H  26
None
1.24A 2hdnJ-3f6uH:
undetectable
2hdnK-3f6uH:
undetectable
2hdnL-3f6uH:
undetectable
2hdnJ-3f6uH:
20.81
2hdnK-3f6uH:
9.21
2hdnL-3f6uH:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo
sapiens)
4 / 4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
None
1.35A 2hrcA-3f6uL:
undetectable
2hrcA-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo
sapiens)
4 / 4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
None
1.24A 2hrcB-3f6uL:
undetectable
2hrcB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 5 PRO H 164
PRO H 161
ILE H 184
GLY H 184
None
1.13A 2jkjD-3f6uH:
undetectable
2jkjD-3f6uH:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 5 PRO H 164
PRO H 161
ILE H 184
GLY H 184
None
1.13A 2jkjF-3f6uH:
undetectable
2jkjF-3f6uH:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 6 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.30A 2otvA-3f6uH:
35.4
2otvA-3f6uH:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 12 GLY H 142
GLY H 196
GLY H 193
THR H  54
LEU H  53
VAL H  31
None
None
0G6  H   1 (-4.1A)
None
None
None
1.22A 2oxtD-3f6uH:
undetectable
2oxtD-3f6uH:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
8 / 12 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
None
0.34A 2p16A-3f6uH:
37.4
2p16A-3f6uH:
37.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo
sapiens)
4 / 4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
None
1.31A 2pnjB-3f6uL:
undetectable
2pnjB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo
sapiens)
4 / 4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
None
1.46A 2qd2A-3f6uL:
undetectable
2qd2A-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 5 LEU H 123
PRO H 124
LEU H 235
ILE H 238
None
0.80A 2qd4A-3f6uH:
undetectable
2qd4A-3f6uH:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 8 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.48A 2vinA-3f6uH:
33.3
2vinA-3f6uH:
35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
9 / 12 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 219
GLY H 226
TYR H 228
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
None
0G6  H   1 ( 3.9A)
None
0.51A 2w26A-3f6uH:
37.3
2w26A-3f6uH:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 11 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.56A 3gy3A-3f6uH:
33.8
3gy3A-3f6uH:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo
sapiens)
4 / 4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
None
1.27A 3hcoB-3f6uL:
undetectable
3hcoB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP4_A_MIIA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 9 ASN H 179
THR H 229
LEU H 212
ALA H  56
HIS H  91
None
1.30A 3kp4A-3f6uH:
undetectable
3kp4B-3f6uH:
undetectable
3kp4A-3f6uH:
20.25
3kp4B-3f6uH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
3 / 3 ASP H 100
SER H 177
ARG H 233
None
1.01A 3loqA-3f6uH:
undetectable
3loqA-3f6uH:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 6 SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.41A 3rxfA-3f6uH:
12.7
3rxfA-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 5 ASP H 189
SER H 195
VAL H 213
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 ( 3.9A)
0.45A 3rxhA-3f6uH:
35.1
3rxhA-3f6uH:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 12 ASN H 179
THR H 229
LEU H 212
ALA H  56
HIS H  91
None
1.33A 4ejwA-3f6uH:
undetectable
4ejwA-3f6uH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 4 LEU H 123
PRO H 124
LEU H 235
ILE H 238
None
0.88A 4f4dB-3f6uH:
undetectable
4f4dB-3f6uH:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
5 / 12 HIS H  57
ASP H 189
GLU H 192
GLY H 216
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 ( 4.0A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.63A 4hfpB-3f6uH:
35.4
4hfpB-3f6uH:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 12 ASP H 189
ALA H 190
GLU H 192
VAL H 213
TRP H 215
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 ( 4.0A)
None
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
0.74A 4hfpD-3f6uH:
35.4
4hfpD-3f6uH:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 12 HIS H  57
ASP H 189
ALA H 190
VAL H 213
TRP H 215
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
None
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
0.38A 4hfpD-3f6uH:
35.4
4hfpD-3f6uH:
39.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 4 TYR H 228
THR H 139
VAL H 200
ILE H 160
None
1.19A 4jx1F-3f6uH:
undetectable
4jx1F-3f6uH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 10 ALA H  55
THR H  54
ALA H 104
ALA H  56
GLY H 211
THR H 229
None
1.45A 4qvyK-3f6uH:
undetectable
4qvyL-3f6uH:
undetectable
4qvyK-3f6uH:
23.62
4qvyL-3f6uH:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 10 ALA H  55
THR H  54
ALA H 104
ALA H  56
GLY H 211
THR H 229
None
1.45A 4qvyY-3f6uH:
undetectable
4qvyZ-3f6uH:
undetectable
4qvyY-3f6uH:
23.62
4qvyZ-3f6uH:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
6 / 12 HIS H  57
ALA H 190
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-3.4A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.91A 4rn6B-3f6uH:
30.6
4rn6B-3f6uH:
36.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
3 / 3 THR H 229
HIS H  48
LEU H 123
None
0.85A 5axdC-3f6uH:
undetectable
5axdC-3f6uH:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 5 TRP H  29
LEU H 212
PRO H 198
LEU H 106
None
1.09A 5eshA-3f6uH:
undetectable
5eshA-3f6uH:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo
sapiens)
4 / 7 GLY H 226
ILE H 158
GLN H  30
ASP H 194
0G6  H   1 ( 3.9A)
None
None
None
0.98A 5vlmC-3f6uH:
undetectable
5vlmC-3f6uH:
20.69