SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		3 / 3 HIS A 369
ASP A 582
ASN A 528
 None
 0.81A 1wg8B-3f70A:
undetectable		 1wg8B-3f70A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 459
PHE A 428
ARG A 564
 None
 0.83A 1xdkB-3f70A:
undetectable		 1xdkB-3f70A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 10 PHE A 179
ALA A 607
ASP A 571
VAL A 555
PHE A 184
 None
 1.21A 3ay0A-3f70A:
undetectable		 3ay0A-3f70A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 572
LEU A 601
CYH A 554
ILE A 568
PHE A 570
 None
None
MLZ  A  20 ( 4.1A)
None
MLZ  A  20 (-4.0A)
 1.35A 3mnoA-3f70A:
undetectable		 3mnoA-3f70A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 572
LEU A 601
CYH A 554
ILE A 568
PHE A 570
 None
None
MLZ  A  20 ( 4.1A)
None
MLZ  A  20 (-4.0A)
 1.33A 3mnpA-3f70A:
undetectable		 3mnpA-3f70A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 CYH A 368
TYR A 357
VAL A 348
ILE A 375
VAL A 332
 None
 1.41A 3sp6A-3f70A:
undetectable		 3sp6A-3f70A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 553
TRP A 593
ILE A 349
LEU A 355
VAL A 331
 None
 1.11A 3w68C-3f70A:
undetectable		 3w68C-3f70A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		4 / 5 VAL A 581
LEU A 566
SER A 567
MET A 540
 None
 1.19A 4e1gA-3f70A:
undetectable		 4e1gA-3f70A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.92A 4fp9A-3f70A:
undetectable		 4fp9A-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.93A 4fp9C-3f70A:
undetectable		 4fp9C-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.93A 4fp9D-3f70A:
undetectable		 4fp9D-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.93A 4fp9F-3f70A:
undetectable		 4fp9F-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.96A 4fzvA-3f70A:
undetectable		 4fzvA-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 280
VAL A 281
PRO A 283
GLU A 217
 None
 0.86A 4lb2A-3f70A:
undetectable		 4lb2A-3f70A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		3 / 3 SER A 335
LEU A 442
MET A 548
 None
 0.86A 5ikrB-3f70A:
undetectable		 5ikrB-3f70A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		4 / 4 PHE A 311
ASP A 310
LEU A 203
LYS A 314
 None
 1.06A 6awvA-3f70A:
undetectable		 6awvA-3f70A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 365
ARG A 551
GLU A 549
CYH A 554
 None
None
MLZ  A  20 ( 4.2A)
MLZ  A  20 ( 4.1A)
 1.45A 6mn5D-3f70A:
undetectable		 6mn5D-3f70A:
13.12