SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		7 / 10 GLN A  25
GLY A  29
SER A  30
TRP A  32
PHE A  34
SER A  35
HIS A 167
 None
 0.25A 1stfE-3f75A:
35.7
1stfI-3f75A:
undetectable		 1stfE-3f75A:
39.91
1stfI-3f75A:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3f75 CATHEPSIN L PROTEASE
CATHEPSIN L
PROPEPTIDE
(Toxoplasma
gondii;
Toxoplasma
gondii) 		7 / 10 GLN A  25
GLY A  29
SER A  30
TRP A  32
PHE A  34
SER A  35
GLY P 179
 None
 0.66A 1stfE-3f75A:
35.7
1stfI-3f75A:
undetectable		 1stfE-3f75A:
39.91
1stfI-3f75A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		5 / 12 ALA A  79
ASP A 120
GLY A 117
LEU A 116
SER A 220
 None
 1.12A 2nv4A-3f75A:
undetectable		 2nv4A-3f75A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		5 / 12 ALA A  79
ASP A 120
GLY A 117
LEU A 116
SER A 220
 None
 1.09A 2nv4B-3f75A:
undetectable		 2nv4B-3f75A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		3 / 3 GLY A  67
ASP A  78
SER A  63
 None
 0.70A 2qhfA-3f75A:
undetectable		 2qhfA-3f75A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		5 / 10 SER A  63
ALA A  79
ASN A  68
ALA A  33
TYR A  82
 None
 1.46A 2r2vC-3f75A:
undetectable
2r2vF-3f75A:
undetectable
2r2vG-3f75A:
undetectable		 2r2vC-3f75A:
9.05
2r2vF-3f75A:
9.05
2r2vG-3f75A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		4 / 7 THR A  20
PRO A  21
VAL A  22
GLU A  56
 None
 1.04A 2v2gA-3f75A:
undetectable
2v2gB-3f75A:
undetectable		 2v2gA-3f75A:
22.64
2v2gB-3f75A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		4 / 7 GLN A  25
GLY A  29
HIS A 167
TRP A 191
 None
 0.40A 3ai8A-3f75A:
27.4		 3ai8A-3f75A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f75 CATHEPSIN L PROTEASE
CATHEPSIN L
PROPEPTIDE
(Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 6 ARG P 170
ASP P 171
ASP A 145
ARG P 174
 CL  A 301 (-4.2A)
None
None
None
 0.98A 4kcnB-3f75P:
undetectable		 4kcnB-3f75P:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		4 / 4 LYS A  23
ASP A  61
GLU A  92
THR A  37
 None
 1.39A 5d4uA-3f75A:
0.0		 5d4uA-3f75A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		4 / 4 LYS A  23
ASP A  61
GLU A  92
THR A  37
 None
 1.40A 5d4uB-3f75A:
undetectable		 5d4uB-3f75A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		4 / 4 LYS A  23
ASP A  61
GLU A  92
THR A  37
 None
 1.38A 5d4uC-3f75A:
0.0		 5d4uC-3f75A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		4 / 4 LYS A  23
ASP A  61
GLU A  92
THR A  37
 None
 1.38A 5d4uD-3f75A:
0.0		 5d4uD-3f75A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		3 / 3 TRP A  32
MET A  76
ASN A  77
 None
 1.29A 5uc1B-3f75A:
undetectable		 5uc1B-3f75A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3f75 CATHEPSIN L PROTEASE
(Toxoplasma
gondii) 		3 / 3 TRP A  32
MET A  76
ASN A  77
 None
 1.29A 5uc1A-3f75A:
undetectable		 5uc1A-3f75A:
19.37