SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 SER A  16
LEU A 236
TYR A  25
GLY A 280
 None
 1.16A 1liiA-3f7oA:
undetectable		 1liiA-3f7oA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 HIS A 232
ALA A 206
PHE A 205
GLY A 208
 None
 1.23A 1mj2B-3f7oA:
undetectable		 1mj2B-3f7oA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 HIS A 232
ALA A 206
PHE A 205
GLY A 208
 None
 1.23A 1mj2D-3f7oA:
undetectable		 1mj2D-3f7oA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 HIS A 232
ALA A 206
PHE A 205
GLY A 208
 None
 1.21A 1mjoB-3f7oA:
undetectable		 1mjoB-3f7oA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 HIS A 232
ALA A 206
PHE A 205
GLY A 208
 None
 1.17A 1mjoA-3f7oA:
undetectable		 1mjoA-3f7oA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 HIS A 232
ALA A 206
PHE A 205
GLY A 208
 None
 1.22A 1mjoD-3f7oA:
undetectable		 1mjoD-3f7oA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 GLY A 235
GLY A 237
TYR A 239
ILE A  15
THR A  84
 None
 1.12A 1p91B-3f7oA:
undetectable		 1p91B-3f7oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 6 LEU A 259
PHE A 278
ALA A 277
LEU A 240
 None
 0.97A 1ukbA-3f7oA:
3.0		 1ukbA-3f7oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 ASN A 133
ALA A 159
LEU A 252
LEU A 236
THR A  79
 None
 1.36A 2aa6B-3f7oA:
undetectable		 2aa6B-3f7oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 ASN A 133
ALA A 159
LEU A 252
LEU A 236
THR A  79
 None
 1.49A 2oaxC-3f7oA:
undetectable		 2oaxC-3f7oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 ASN A 133
ALA A 159
LEU A 252
LEU A 236
THR A  79
 None
 1.46A 2oaxF-3f7oA:
undetectable		 2oaxF-3f7oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 GLY A 225
GLY A 208
SER A 196
ASP A 165
SER A 227
 None
 1.38A 3dlcA-3f7oA:
undetectable		 3dlcA-3f7oA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 11 GLY A  95
GLY A  43
ALA A  77
THR A  74
ALA A  37
 None
 1.11A 3g88B-3f7oA:
undetectable		 3g88B-3f7oA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 5 ILE A 268
PRO A 269
SER A 194
GLY A 267
 None
 1.11A 3tkdB-3f7oA:
undetectable		 3tkdB-3f7oA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 5 ILE A 268
PRO A 269
SER A 194
GLY A 267
 None
 1.12A 3tkdA-3f7oA:
undetectable		 3tkdA-3f7oA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 ASN A 133
ALA A 159
LEU A 252
LEU A 236
THR A  79
 None
 1.45A 3vhuA-3f7oA:
undetectable		 3vhuA-3f7oA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 8 LEU A 136
SER A 227
THR A  74
ASP A  68
 None
 0.99A 4drjB-3f7oA:
undetectable		 4drjB-3f7oA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 8 ASN A  66
GLN A  65
GLY A  64
SER A  63
 None
 0.72A 4f93B-3f7oA:
undetectable		 4f93B-3f7oA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 6 ASN A 200
ASP A 203
GLY A 184
PRO A 269
 None
CA  A 286 (-3.1A)
None
None
 1.07A 4l1aB-3f7oA:
undetectable		 4l1aB-3f7oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 GLY A  78
GLY A  81
THR A 214
ILE A 216
GLY A  73
 None
 1.05A 4n48A-3f7oA:
2.7		 4n48A-3f7oA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 MET A 151
VAL A 156
LEU A 158
ILE A  40
ALA A  37
 None
 1.09A 4o1zB-3f7oA:
undetectable		 4o1zB-3f7oA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 7 LEU A 136
THR A 182
ALA A 161
THR A 226
 None
CA  A 286 (-3.6A)
None
None
 1.05A 5bojB-3f7oA:
undetectable		 5bojB-3f7oA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 4 VAL A 202
ALA A 161
ILE A 233
THR A 230
 None
 0.90A 5e4dB-3f7oA:
undetectable		 5e4dB-3f7oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 8 PHE A  51
GLY A  53
THR A  74
TYR A  85
 None
 0.93A 5flcB-3f7oA:
undetectable		 5flcB-3f7oA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 8 PHE A  51
GLY A  53
THR A  74
TYR A  85
 None
 0.93A 5flcF-3f7oA:
undetectable		 5flcF-3f7oA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 VAL A 160
VAL A 144
GLY A 147
ALA A 148
LEU A 158
 None
 1.13A 5iktA-3f7oA:
undetectable		 5iktA-3f7oA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		5 / 12 GLY A  95
PHE A 116
GLY A 155
VAL A 130
GLY A 113
 None
 0.95A 5koxA-3f7oA:
undetectable		 5koxA-3f7oA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 8 ARG A  54
ALA A  37
VAL A 131
GLY A 235
 None
 0.92A 5v0vA-3f7oA:
undetectable		 5v0vA-3f7oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3f7o SERINE PROTEASE
(Purpureocillium
lilacinum) 		4 / 6 ARG A 192
GLY A 267
SER A 194
THR A 187
 None
 1.00A 5ysiA-3f7oA:
undetectable		 5ysiA-3f7oA:
18.47