SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MCL_P_DHIP1_0 (IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) N-ACETYL-D-HIS-L-PRO -OH)	3f7x	PUTATIVE POLYKETIDE CYCLASE (Pseudomonas putida)	4 / 5	TYR A 100 GLU A 59 TYR A 122 PRO A 103	UNL A 133 ( 4.9A) UNL A 133 ( 2.9A) UNL A 133 (-3.8A) EDO A 140 ( 4.6A)	1.38A	1mclA-3f7xA: undetectable 1mclB-3f7xA: undetectable 1mclP-3f7xA: undetectable	1mclA-3f7xA: 18.69 1mclB-3f7xA: 18.69 1mclP-3f7xA: 5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CLA_A_CLMA221_0 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	3f7x	PUTATIVE POLYKETIDE CYCLASE (Pseudomonas putida)	5 / 11	ALA A 104 LEU A 61 PHE A 79 PHE A 49 ILE A 34	UNL A 133 (-3.4A) None None UNL A 134 (-3.3A) None	1.33A	4claA-3f7xA: undetectable	4claA-3f7xA: 20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECO_A_LEUA602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3f7x	PUTATIVE POLYKETIDE CYCLASE (Pseudomonas putida)	4 / 6	THR A 2 ALA A 3 THR A 4 VAL A 7	None	0.38A	5ecoA-3f7xA: undetectable	5ecoA-3f7xA: 13.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MCL_P_DHIP1_0","IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN);N-ACETYL-D-HIS-L-PRO-OH","3f7x","PUTATIVE POLYKETIDE CYCLASE","Pseudomonas putida",4,"TYR A 100;GLU A  59;TYR A 122;PRO A 103","UNL A 133 ( 4.9A);UNL A 133 ( 2.9A);UNL A 133 (-3.8A);EDO A 140 ( 4.6A)","1.38A","1mclA-3f7xA:undetectable;1mclB-3f7xA:undetectable;1mclP-3f7xA:undetectable","1mclA-3f7xA:18.69;1mclB-3f7xA:18.69;1mclP-3f7xA:5.13"],["4CLA_A_CLMA221_0","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","3f7x","PUTATIVE POLYKETIDE CYCLASE","Pseudomonas putida",5,"ALA A 104;LEU A  61;PHE A  79;PHE A  49;ILE A  34","UNL A 133 (-3.4A);None;None;UNL A 134 (-3.3A);None","1.33A","4claA-3f7xA:undetectable","4claA-3f7xA:20.91"],["5ECO_A_LEUA602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","3f7x","PUTATIVE POLYKETIDE CYCLASE","Pseudomonas putida",4,"THR A   2;ALA A   3;THR A   4;VAL A   7","None","0.38A","5ecoA-3f7xA:undetectable","5ecoA-3f7xA:13.17"]]