SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		3 / 3 ASP A 146
THR A  34
PRO A  35
 None
 0.69A 2pynB-3f81A:
undetectable		 2pynB-3f81A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		3 / 3 ASP A 146
THR A  34
PRO A  35
 None
 0.69A 2qakB-3f81A:
undetectable		 2qakB-3f81A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 PHE A  77
ARG A 125
ASN A  41
GLY A 127
ARG A 158
 None
None
None
STT  A   1 ( 4.5A)
None
 1.25A 3aobC-3f81A:
undetectable		 3aobC-3f81A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 PHE A  77
ARG A 125
ASN A  41
GLY A 127
ARG A 158
 None
None
None
STT  A   1 ( 4.5A)
None
 1.29A 3aodC-3f81A:
undetectable		 3aodC-3f81A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		3 / 3 LYS A 182
ARG A 176
ASP A 107
 None
 1.25A 3o7wA-3f81A:
undetectable		 3o7wA-3f81A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		3 / 3 TYR A  38
LEU A 151
ARG A 158
 None
 0.80A 3sufB-3f81A:
undetectable		 3sufB-3f81A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.48A 4p6xA-3f81A:
undetectable		 4p6xA-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.47A 4p6xE-3f81A:
undetectable		 4p6xE-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.49A 4p6xG-3f81A:
undetectable		 4p6xG-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.44A 4p6xI-3f81A:
undetectable		 4p6xI-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		4 / 4 ASN A 163
VAL A   9
THR A 133
ILE A 136
 None
 1.34A 4retA-3f81A:
3.6		 4retA-3f81A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		4 / 4 ASN A 163
VAL A   9
THR A 133
ILE A 136
 None
 1.34A 4retC-3f81A:
3.6		 4retC-3f81A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		5 / 12 GLY A 127
ILE A 160
HIS A 123
VAL A  39
VAL A  33
 STT  A   1 ( 4.5A)
None
None
None
None
 1.11A 5dpdA-3f81A:
undetectable		 5dpdA-3f81A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3
(Homo
sapiens) 		4 / 4 LYS A  50
HIS A 123
VAL A 122
ASN A  31
 None
 1.48A 5l2iA-3f81A:
0.0		 5l2iA-3f81A:
19.65