SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		3 / 3 ASP A 241
PHE A 167
ASN A 197
 None
 0.76A 1sg9B-3f83A:
undetectable		 1sg9B-3f83A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		3 / 3 ASP A  24
TYR A  58
LYS A 126
 None
None
NA  A   1 ( 4.2A)
 1.08A 2othA-3f83A:
undetectable		 2othA-3f83A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		5 / 11 LEU A 290
ILE A 252
PHE A 239
PHE A 254
LEU A 333
 None
 1.19A 3a9eB-3f83A:
undetectable		 3a9eB-3f83A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		5 / 12 ALA A 427
LEU A 505
ILE A 483
LEU A 481
LEU A 453
 None
 1.15A 3k2hA-3f83A:
undetectable		 3k2hA-3f83A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		4 / 4 ARG A 232
ASP A 256
GLY A 263
THR A 291
 None
 1.48A 3k4vB-3f83A:
undetectable		 3k4vB-3f83A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		4 / 5 LEU A 290
ARG A 253
ILE A 351
PHE A 254
 None
 1.16A 3ln1D-3f83A:
undetectable		 3ln1D-3f83A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		4 / 6 ILE A 157
GLU A 161
ALA A 159
ASN A 163
 None
 1.10A 3pgyA-3f83A:
undetectable
3pgyB-3f83A:
undetectable		 3pgyA-3f83A:
21.17
3pgyB-3f83A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		4 / 8 VAL A 446
VAL A 503
ILE A 520
LEU A 381
 None
 0.90A 4jq1B-3f83A:
undetectable		 4jq1B-3f83A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		5 / 12 ILE A 100
ILE A  94
GLY A  96
ALA A 135
LEU A 155
 None
 0.99A 4o1zA-3f83A:
undetectable		 4o1zA-3f83A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		5 / 12 LEU A 381
VAL A 424
VAL A 422
LEU A 465
PHE A 460
 None
 0.84A 4y0qA-3f83A:
undetectable		 4y0qA-3f83A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		5 / 12 LEU A 381
VAL A 424
VAL A 422
LEU A 465
PHE A 460
 None
 0.86A 4y0sA-3f83A:
undetectable		 4y0sA-3f83A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		4 / 7 GLY A 242
ASP A 241
GLY A 168
GLU A 106
 None
 0.90A 4z53A-3f83A:
undetectable
4z53B-3f83A:
undetectable		 4z53A-3f83A:
23.27
4z53B-3f83A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB
(Escherichia
coli) 		4 / 5 ILE A 111
PHE A 167
ARG A 108
THR A 307
 None
 1.29A 5z84N-3f83A:
undetectable
5z84W-3f83A:
undetectable		 5z84N-3f83A:
22.45
5z84W-3f83A:
8.67