SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 GLU A 386
ASP A 437
LEU A 434
GLY A 435
ALA A 270
 None
 1.05A 1hvyA-3f85A:
undetectable		 1hvyA-3f85A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 GLU A 386
ASP A 437
LEU A 434
GLY A 435
ALA A 270
 None
 1.12A 1hvyB-3f85A:
undetectable		 1hvyB-3f85A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 GLU A 386
ASP A 437
LEU A 434
GLY A 435
ALA A 270
 None
 1.12A 1hvyD-3f85A:
undetectable		 1hvyD-3f85A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 283
ASP A  57
VAL A  63
ASN A  60
ASP A 286
 None
 1.27A 2x2iB-3f85A:
undetectable		 2x2iB-3f85A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 THR A  34
LEU A  12
VAL A  16
ILE A  67
LEU A 128
 None
 1.03A 3ijdA-3f85A:
undetectable		 3ijdA-3f85A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 ALA A  50
LEU A 128
ILE A 106
LEU A 104
LEU A  76
 None
 1.10A 3k2hA-3f85A:
undetectable		 3k2hA-3f85A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 ALA A 201
LEU A 279
ILE A 257
LEU A 255
LEU A 227
 None
 1.13A 3k2hA-3f85A:
undetectable		 3k2hA-3f85A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 8 VAL A  69
VAL A 126
ILE A 143
LEU A   4
 None
 0.89A 4jq1B-3f85A:
undetectable		 4jq1B-3f85A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 8 VAL A 220
VAL A 277
ILE A 294
LEU A 155
 None
 0.88A 4jq1B-3f85A:
undetectable		 4jq1B-3f85A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 8 VAL A 371
VAL A 428
ILE A 445
LEU A 306
 None
 0.92A 4jq1B-3f85A:
undetectable		 4jq1B-3f85A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 6 VAL A  69
VAL A 126
ILE A 143
LEU A   4
 None
 0.97A 4l1wB-3f85A:
undetectable		 4l1wB-3f85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 6 VAL A 220
VAL A 277
ILE A 294
LEU A 155
 None
 0.97A 4l1wB-3f85A:
undetectable		 4l1wB-3f85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 6 VAL A 371
VAL A 428
ILE A 445
LEU A 306
 None
 0.98A 4l1wB-3f85A:
undetectable		 4l1wB-3f85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 8 LEU A 351
LEU A 430
VAL A 428
ILE A 408
 None
 0.90A 4oj4A-3f85A:
undetectable		 4oj4A-3f85A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 155
VAL A 198
VAL A 196
LEU A 239
PHE A 234
 None
 0.87A 4y0pA-3f85A:
undetectable		 4y0pA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 306
VAL A 349
VAL A 347
LEU A 390
PHE A 385
 None
 0.82A 4y0pA-3f85A:
undetectable		 4y0pA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A   4
VAL A  47
VAL A  45
LEU A  88
PHE A  83
 None
 0.84A 4y0qA-3f85A:
undetectable		 4y0qA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 155
VAL A 198
VAL A 196
LEU A 239
PHE A 234
 None
 0.84A 4y0qA-3f85A:
undetectable		 4y0qA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 306
VAL A 349
VAL A 347
LEU A 390
PHE A 385
 None
 0.79A 4y0qA-3f85A:
undetectable		 4y0qA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A   4
VAL A  47
VAL A  45
LEU A  88
PHE A  83
 None
 0.90A 4y0sA-3f85A:
undetectable		 4y0sA-3f85A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 155
VAL A 198
VAL A 196
LEU A 239
PHE A 234
 None
 0.88A 4y0sA-3f85A:
undetectable		 4y0sA-3f85A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		5 / 12 LEU A 306
VAL A 349
VAL A 347
LEU A 390
PHE A 385
 None
 0.84A 4y0sA-3f85A:
undetectable		 4y0sA-3f85A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		4 / 6 ALA A 343
LEU A 390
SER A 401
THR A 340
 None
 1.24A 5l4iB-3f85A:
undetectable		 5l4iB-3f85A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		3 / 3 VAL A 280
ALA A 201
GLN A 289
 None
 0.68A 6gb9A-3f85A:
undetectable		 6gb9A-3f85A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B
(Escherichia
coli) 		3 / 3 VAL A 431
ALA A 352
GLN A 440
 None
 0.55A 6gb9A-3f85A:
undetectable		 6gb9A-3f85A:
23.77