SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		4 / 5 TYR A  98
GLU A  57
TYR A 120
PRO A 101
 MRD  A 134 (-4.2A)
MRD  A 134 ( 2.7A)
MRD  A 134 (-3.9A)
None
 1.40A 1mclA-3f8hA:
undetectable
1mclB-3f8hA:
undetectable
1mclP-3f8hA:
undetectable		 1mclA-3f8hA:
19.72
1mclB-3f8hA:
19.72
1mclP-3f8hA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A  28
LEU A  24
MET A  20
TYR A   8
PHE A  47
 None
None
MRD  A 135 ( 3.9A)
None
None
 1.45A 1p5zB-3f8hA:
undetectable		 1p5zB-3f8hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A  28
LEU A  24
MET A  20
TYR A   8
PHE A  47
 None
None
MRD  A 135 ( 3.9A)
None
None
 1.45A 2no0A-3f8hA:
undetectable		 2no0A-3f8hA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A  28
MET A  20
TYR A   8
ALA A  46
PHE A  47
 None
MRD  A 135 ( 3.9A)
None
None
None
 1.34A 2vppA-3f8hA:
undetectable		 2vppA-3f8hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A  28
MET A  20
TYR A   8
ALA A  46
PHE A  47
 None
MRD  A 135 ( 3.9A)
None
None
None
 1.33A 2vppB-3f8hA:
undetectable		 2vppB-3f8hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A  28
LEU A  24
MET A  20
TYR A   8
PHE A  47
 None
None
MRD  A 135 ( 3.9A)
None
None
 1.45A 2ziaB-3f8hA:
undetectable		 2ziaB-3f8hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		3 / 3 THR A   4
SER A  25
LYS A  41
 None
 0.96A 3aocC-3f8hA:
undetectable		 3aocC-3f8hA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A  28
MET A  20
TYR A   8
ALA A  46
PHE A  47
 None
MRD  A 135 ( 3.9A)
None
None
None
 1.34A 3hp1A-3f8hA:
0.0		 3hp1A-3f8hA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		4 / 8 TYR A  77
TYR A 120
GLU A  57
ILE A 113
 None
MRD  A 134 (-3.9A)
MRD  A 134 ( 2.7A)
None
 0.83A 3jz0B-3f8hA:
undetectable		 3jz0B-3f8hA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		4 / 4 SER A 104
ASP A 107
ASP A  69
ALA A  73
 MPD  A 133 (-3.6A)
None
None
None
 1.43A 3uj6A-3f8hA:
undetectable		 3uj6A-3f8hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3f8h PUTATIVE POLYKETIDE
CYCLASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A 116
THR A 118
LEU A  24
PHE A  44
PHE A   9
 None
MPD  A 133 ( 3.3A)
None
None
None
 1.08A 6drzA-3f8hA:
undetectable		 6drzA-3f8hA:
17.09