SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		3 / 3 ARG A  36
TYR A  83
LYS A  82
 None
 1.07A 1uujB-3f8rA:
undetectable		 1uujB-3f8rA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 11 HIS A  79
PHE A  76
ALA A  31
VAL A 298
TYR A  61
 None
 1.27A 2gl0B-3f8rA:
undetectable
2gl0C-3f8rA:
undetectable		 2gl0B-3f8rA:
21.47
2gl0C-3f8rA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 11 HIS A  79
PHE A  76
ALA A  31
VAL A 298
TYR A  61
 None
 1.25A 2gl0E-3f8rA:
undetectable
2gl0F-3f8rA:
undetectable		 2gl0E-3f8rA:
21.47
2gl0F-3f8rA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 8 GLY A 161
GLY A 162
ALA A 166
PHE A 207
PHE A 189
 NAP  A4001 ( 4.1A)
NAP  A4001 ( 4.6A)
None
None
None
 1.24A 2ha4A-3f8rA:
undetectable		 2ha4A-3f8rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 6 PRO A  48
GLY A  24
ILE A  20
GLY A  22
 None
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.1A)
 0.84A 2jkjA-3f8rA:
undetectable		 2jkjA-3f8rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 6 PRO A  48
GLY A  24
ILE A  20
GLY A  22
 None
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.1A)
 0.83A 2jkjB-3f8rA:
undetectable		 2jkjB-3f8rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 6 PRO A  48
GLY A  24
ILE A  20
GLY A  22
 None
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.1A)
 0.84A 2jkjC-3f8rA:
undetectable		 2jkjC-3f8rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 PRO A  48
GLY A  24
ILE A  20
GLY A  22
 None
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.1A)
 0.83A 2jkjE-3f8rA:
undetectable		 2jkjE-3f8rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 6 PRO A  48
GLY A  24
ILE A  20
GLY A  22
 None
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.1A)
 0.83A 2jklB-3f8rA:
undetectable		 2jklB-3f8rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 PRO A  48
GLY A  24
ILE A  20
GLY A  22
 None
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.1A)
 0.84A 2jklE-3f8rA:
undetectable		 2jklE-3f8rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 ALA A 301
THR A 300
ALA A 303
TYR A  61
 NAP  A4005 ( 4.0A)
None
None
None
 0.92A 2ql8A-3f8rA:
undetectable
2ql8B-3f8rA:
undetectable		 2ql8A-3f8rA:
18.69
2ql8B-3f8rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 10 VAL A 104
ILE A  95
LEU A 119
GLY A 120
ALA A  27
 None
 1.15A 2xf3A-3f8rA:
undetectable		 2xf3A-3f8rA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 GLY A 120
ALA A 308
ALA A  30
ILE A 269
 None
 0.81A 3a2qA-3f8rA:
undetectable		 3a2qA-3f8rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 THR A 289
ILE A 121
MET A 275
ILE A 118
VAL A 104
 None
NAP  A4005 (-3.8A)
None
None
None
 1.13A 3a51D-3f8rA:
undetectable		 3a51D-3f8rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 LEU A 119
ALA A  31
THR A  41
VAL A  18
GLU A  81
 None
 1.01A 3cwkA-3f8rA:
undetectable		 3cwkA-3f8rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 162
GLY A 161
SER A 165
VAL A 196
ARG A 186
 NAP  A4001 ( 4.6A)
NAP  A4001 ( 4.1A)
NAP  A4001 (-2.9A)
None
NAP  A4001 (-3.3A)
 1.40A 3dlcA-3f8rA:
3.6		 3dlcA-3f8rA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.98A 3eluA-3f8rA:
undetectable		 3eluA-3f8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.96A 3elwA-3f8rA:
undetectable		 3elwA-3f8rA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 1.03A 3embA-3f8rA:
undetectable		 3embA-3f8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 10 ALA A  30
ALA A  31
VAL A 271
ILE A 269
CYH A 288
 None
 1.03A 3falA-3f8rA:
undetectable		 3falA-3f8rA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.91A 3gczA-3f8rA:
undetectable		 3gczA-3f8rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		6 / 12 ALA A  30
ALA A  27
ALA A  31
VAL A 271
ILE A 269
CYH A 288
 None
 1.42A 3h0aA-3f8rA:
undetectable		 3h0aA-3f8rA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 169
ALA A 166
GLU A 246
ASP A 148
ALA A 149
 None
 1.19A 3nmuA-3f8rA:
undetectable
3nmuF-3f8rA:
3.3		 3nmuA-3f8rA:
22.33
3nmuF-3f8rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 ALA A 284
VAL A 279
VAL A 282
LEU A 119
 None
 0.80A 3o14A-3f8rA:
undetectable		 3o14A-3f8rA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 11 ALA A  27
VAL A  43
ILE A  80
VAL A  18
ILE A  20
 None
 1.04A 3oxvD-3f8rA:
undetectable		 3oxvD-3f8rA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 9 ALA A 114
ASP A  17
GLY A  13
ILE A  44
ILE A  19
 None
 0.90A 3s43A-3f8rA:
undetectable		 3s43A-3f8rA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLN A  51
GLY A 122
ILE A 299
ALA A  26
ALA A 303
 NAP  A4005 (-3.7A)
NAP  A4005 (-3.4A)
None
NAP  A4005 (-3.6A)
None
 0.91A 3sudC-3f8rA:
undetectable		 3sudC-3f8rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		6 / 12 GLY A 305
ALA A 285
ILE A 121
GLY A  22
VAL A  18
ILE A 118
 None
None
NAP  A4005 (-3.8A)
NAP  A4005 (-3.1A)
None
None
 1.50A 3tl9B-3f8rA:
undetectable		 3tl9B-3f8rA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.92A 4ctjC-3f8rA:
undetectable		 4ctjC-3f8rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 VAL A 213
VAL A 225
LEU A 238
VAL A 156
 None
 1.03A 4e1gB-3f8rA:
undetectable		 4e1gB-3f8rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 9 ASP A 164
VAL A 199
TYR A 195
GLY A 162
GLY A 169
 NAP  A4001 (-4.2A)
None
NAP  A4001 (-4.5A)
NAP  A4001 ( 4.6A)
None
 1.34A 4mmbA-3f8rA:
undetectable		 4mmbA-3f8rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 10 ASP A 164
VAL A 199
TYR A 195
GLY A 162
GLY A 169
 NAP  A4001 (-4.2A)
None
NAP  A4001 (-4.5A)
NAP  A4001 ( 4.6A)
None
 1.29A 4mmcA-3f8rA:
undetectable		 4mmcA-3f8rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 9 ASP A 164
VAL A 199
TYR A 195
GLY A 162
GLY A 169
 NAP  A4001 (-4.2A)
None
NAP  A4001 (-4.5A)
NAP  A4001 ( 4.6A)
None
 1.34A 4mmfB-3f8rA:
undetectable		 4mmfB-3f8rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 9 ALA A  30
VAL A 123
GLY A 286
ALA A 285
ILE A  20
 None
None
NAP  A4005 (-3.3A)
None
None
 1.04A 4r21B-3f8rA:
undetectable		 4r21B-3f8rA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		3 / 3 ASP A 264
ARG A 126
ARG A 296
 None
NAP  A4001 (-3.0A)
NAP  A4001 (-3.2A)
 0.99A 4x5iA-3f8rA:
undetectable		 4x5iA-3f8rA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 5 ILE A  44
VAL A  92
ILE A  95
VAL A  21
 None
NAP  A4005 (-3.8A)
None
NAP  A4005 ( 4.9A)
 0.70A 4xdtA-3f8rA:
undetectable		 4xdtA-3f8rA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 8 LYS A 217
VAL A 243
GLN A 224
GLU A 215
 None
 1.05A 5dqyA-3f8rA:
undetectable		 5dqyA-3f8rA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		3 / 3 ASP A 264
ARG A 126
ARG A 296
 None
NAP  A4001 (-3.0A)
NAP  A4001 (-3.2A)
 0.82A 5eajB-3f8rA:
1.9		 5eajB-3f8rA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.91A 5ehgC-3f8rA:
undetectable		 5ehgC-3f8rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.97A 5ehiA-3f8rA:
undetectable		 5ehiA-3f8rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.97A 5eiwA-3f8rA:
undetectable		 5eiwA-3f8rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.97A 5ekxA-3f8rA:
undetectable		 5ekxA-3f8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 5 GLU A 101
GLU A 111
THR A 106
LEU A  42
 None
 1.13A 5hm8G-3f8rA:
4.6		 5hm8G-3f8rA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 7 GLY A  24
VAL A  87
ILE A  44
VAL A  43
 NAP  A4005 (-3.3A)
None
None
None
 0.77A 5ik1A-3f8rA:
undetectable		 5ik1A-3f8rA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 6 GLY A  50
ASP A 148
ILE A 245
ARG A 125
 NAP  A4005 (-3.5A)
None
None
None
 0.89A 5iwuA-3f8rA:
undetectable		 5iwuA-3f8rA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.93A 5kqrA-3f8rA:
undetectable		 5kqrA-3f8rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.92A 5kqsA-3f8rA:
undetectable		 5kqsA-3f8rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.89A 5m5bA-3f8rA:
undetectable		 5m5bA-3f8rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.90A 5njvA-3f8rA:
undetectable		 5njvA-3f8rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.88A 5njvB-3f8rA:
undetectable		 5njvB-3f8rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		6 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
VAL A  92
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
NAP  A4005 (-3.8A)
 1.47A 5njvC-3f8rA:
2.6		 5njvC-3f8rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.94A 5vimA-3f8rA:
undetectable		 5vimA-3f8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.96A 5vimB-3f8rA:
undetectable		 5vimB-3f8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.91A 5wz1B-3f8rA:
undetectable		 5wz1B-3f8rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.94A 5wz2C-3f8rA:
undetectable		 5wz2C-3f8rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		5 / 12 LEU A  39
GLU A 318
VAL A 316
THR A 310
ARG A 314
 None
 1.11A 5xipD-3f8rA:
undetectable		 5xipD-3f8rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 3f8r THIOREDOXIN
REDUCTASE (TRXB-3)
(Sulfolobus
solfataricus) 		4 / 6 GLY A  24
ASP A 287
GLY A  29
GLY A 305
 NAP  A4005 (-3.3A)
NAP  A4005 (-3.8A)
None
None
 0.77A 6ag0C-3f8rA:
undetectable		 6ag0C-3f8rA:
13.61