SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 10 GLU A 219
ALA A 218
MET A 224
LEU A 482
GLU A 481
 None
 1.41A 1a29A-3f8tA:
undetectable		 1a29A-3f8tA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 11 ILE A 374
TRP A 485
LEU A 244
GLY A 246
VAL A 221
 None
 1.47A 1axwB-3f8tA:
undetectable		 1axwB-3f8tA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		3 / 3 VAL A 146
ALA A 147
HIS A 136
 None
 0.66A 1q23H-3f8tA:
undetectable		 1q23H-3f8tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		3 / 3 VAL A 146
ALA A 147
HIS A 136
 None
 0.74A 1q23G-3f8tA:
undetectable		 1q23G-3f8tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		3 / 3 VAL A 146
ALA A 147
HIS A 136
 None
 0.66A 1q23J-3f8tA:
undetectable		 1q23J-3f8tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 11 LEU A 320
ALA A 296
GLY A 301
GLY A 302
ILE A 303
 None
 0.85A 1sduA-3f8tA:
undetectable		 1sduA-3f8tA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 10 LEU A 320
ALA A 296
GLY A 301
GLY A 302
ILE A 303
 None
 0.85A 1sdvA-3f8tA:
undetectable		 1sdvA-3f8tA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 6 LEU A 283
GLU A 127
ALA A 281
VAL A 297
 None
 1.18A 1sn5A-3f8tA:
undetectable		 1sn5A-3f8tA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 ILE A 212
ALA A 209
ARG A 210
MET A 224
LEU A 244
 None
 1.40A 1y0xX-3f8tA:
undetectable		 1y0xX-3f8tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 6 ASN A 347
LEU A 243
LEU A 377
ILE A 361
 None
 0.91A 1z95A-3f8tA:
undetectable		 1z95A-3f8tA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 9 GLU A 238
LEU A 482
LEU A 227
ARG A 464
ALA A 463
 None
 1.49A 2bxcB-3f8tA:
undetectable		 2bxcB-3f8tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 9 LEU A 101
ARG A  60
LEU A 164
HIS A 178
LEU A 175
 None
 1.33A 2bxeA-3f8tA:
undetectable		 2bxeA-3f8tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 LEU A 320
ALA A 296
GLY A 301
GLY A 302
ILE A 303
 None
 0.90A 2o4kA-3f8tA:
undetectable		 2o4kA-3f8tA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		3 / 3 ILE A 346
ILE A 374
LEU A 279
 None
 0.55A 2prgA-3f8tA:
undetectable		 2prgA-3f8tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 4 LEU A  46
ALA A  89
VAL A  92
PRO A  94
 None
 0.98A 3gv1B-3f8tA:
undetectable		 3gv1B-3f8tA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 GLY A 165
PHE A 105
ILE A 119
LEU A  59
GLU A  78
 None
 1.10A 3o7wA-3f8tA:
2.3		 3o7wA-3f8tA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 7 ILE A 121
ILE A 119
VAL A 167
LEU A 172
 None
 0.70A 3r9vA-3f8tA:
undetectable
3r9vB-3f8tA:
undetectable		 3r9vA-3f8tA:
20.04
3r9vB-3f8tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 CYH A 251
LEU A 255
LEU A 225
MET A 224
ALA A 375
 None
 1.21A 3ut5D-3f8tA:
undetectable		 3ut5D-3f8tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 6 ARG A 197
ASP A 475
GLU A 238
LEU A 467
 None
 1.22A 4ax8A-3f8tA:
undetectable		 4ax8A-3f8tA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		3 / 3 LEU A 403
ILE A 407
ARG A 464
 None
 0.69A 4mk4B-3f8tA:
undetectable		 4mk4B-3f8tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 7 VAL A  55
ILE A  36
ALA A  80
ILE A  34
 None
 0.84A 4uxqA-3f8tA:
undetectable		 4uxqA-3f8tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 7 LEU A 279
LEU A 271
ALA A 312
ALA A 319
 None
 0.61A 4z90F-3f8tA:
undetectable
4z90G-3f8tA:
undetectable
4z90H-3f8tA:
undetectable
4z90J-3f8tA:
undetectable		 4z90F-3f8tA:
23.40
4z90G-3f8tA:
23.40
4z90H-3f8tA:
23.40
4z90J-3f8tA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 10 LEU A 304
ALA A 344
LEU A 255
LEU A 259
LEU A 271
 None
 1.36A 5dxeB-3f8tA:
undetectable		 5dxeB-3f8tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		4 / 5 HIS A 316
VAL A 329
GLY A 294
ALA A 281
 None
 1.04A 5hwaA-3f8tA:
undetectable		 5hwaA-3f8tA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 LEU A  46
GLN A  43
PHE A  42
LEU A  33
VAL A  22
 None
 1.23A 5i8fA-3f8tA:
undetectable		 5i8fA-3f8tA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		3 / 3 PRO A 473
ARG A 422
GLU A 418
 None
 0.86A 5j6hA-3f8tA:
undetectable		 5j6hA-3f8tA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 VAL A 297
ASP A 300
LEU A 134
ARG A 265
GLY A 123
 None
 1.16A 5m50E-3f8tA:
undetectable		 5m50E-3f8tA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 12 ALA A 263
VAL A 242
MET A 465
LEU A 377
LEU A 244
 None
 1.10A 5xxiA-3f8tA:
undetectable		 5xxiA-3f8tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY
(Methanopyrus
kandleri) 		5 / 10 ALA A 299
LEU A 304
VAL A 267
VAL A 306
ALA A 319
 None
 1.43A 6h1lA-3f8tA:
undetectable		 6h1lA-3f8tA:
23.86