SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		4 / 6 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.96A 1ictB-3f8uB:
2.1		 1ictB-3f8uB:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3f8u TAPASIN
(Homo
sapiens) 		3 / 3 TRP B 103
VAL B  77
PRO B  78
 None
 0.89A 1rg1A-3f8uB:
undetectable		 1rg1A-3f8uB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3f8u TAPASIN
(Homo
sapiens) 		3 / 3 TRP B 103
VAL B  77
PRO B  78
 None
 0.88A 1rh0A-3f8uB:
undetectable		 1rh0A-3f8uB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		3 / 3 LEU B 115
LEU B 142
SER B 161
 None
None
NAG  B1233 ( 4.6A)
 0.44A 1tlmA-3f8uB:
undetectable		 1tlmA-3f8uB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		5 / 11 ALA B  57
ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
None
NAG  B1233 ( 4.6A)
None
 1.02A 1tz8A-3f8uB:
4.3
1tz8B-3f8uB:
3.8		 1tz8A-3f8uB:
15.36
1tz8B-3f8uB:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3f8u TAPASIN
(Homo
sapiens) 		5 / 12 GLY B 317
GLY B 315
GLY B 357
TYR B 360
PRO B 348
 None
 1.11A 1y4lA-3f8uB:
undetectable		 1y4lA-3f8uB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 3f8u TAPASIN
(Homo
sapiens) 		5 / 12 VAL B 150
GLU B 246
GLY B 247
TYR B 269
ARG B 187
 None
 1.39A 2cl5B-3f8uB:
undetectable		 2cl5B-3f8uB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3f8u TAPASIN
(Homo
sapiens) 		5 / 12 LEU B  55
LEU B 118
ILE B   5
LEU B 115
LEU B 113
 None
 1.00A 2zbpA-3f8uB:
undetectable		 2zbpA-3f8uB:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		4 / 6 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.67A 3cfqA-3f8uB:
undetectable		 3cfqA-3f8uB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		4 / 7 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.76A 3cfqA-3f8uB:
undetectable
3cfqB-3f8uB:
4.0		 3cfqA-3f8uB:
12.66
3cfqB-3f8uB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		4 / 7 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.84A 4d7bA-3f8uB:
3.8		 4d7bA-3f8uB:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		4 / 6 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.90A 4ikiB-3f8uB:
undetectable		 4ikiB-3f8uB:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3f8u TAPASIN
(Homo
sapiens) 		4 / 7 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.82A 4ikkA-3f8uB:
2.9
4ikkB-3f8uB:
undetectable		 4ikkA-3f8uB:
15.36
4ikkB-3f8uB:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3f8u TAPASIN
(Homo
sapiens) 		5 / 12 GLU B 311
ALA B 323
ARG B 313
ALA B 358
GLY B 317
 None
 1.09A 4oaeA-3f8uB:
undetectable		 4oaeA-3f8uB:
18.52