SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.93A 1ddrA-3f9kA:
undetectable		 1ddrA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.98A 1ddrB-3f9kA:
undetectable		 1ddrB-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.98A 1ddsA-3f9kA:
undetectable		 1ddsA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.91A 1ddsB-3f9kA:
undetectable		 1ddsB-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 0.99A 1dhiA-3f9kA:
undetectable		 1dhiA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 0.99A 1dhjA-3f9kA:
undetectable		 1dhjA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
LEU A 177
ILE A  73
LEU A 158
ILE A 162
 None
 1.06A 1draB-3f9kA:
undetectable		 1draB-3f9kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.00A 1drbA-3f9kA:
undetectable		 1drbA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.01A 1drbB-3f9kA:
undetectable		 1drbB-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.99A 1drbB-3f9kA:
undetectable		 1drbB-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 4 LEU A  22
VAL A  37
CYH A  40
ALA A  41
 None
None
ZN  A 210 (-2.1A)
None
 1.25A 1mz9E-3f9kA:
undetectable		 1mz9E-3f9kA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		3 / 3 ARG A 107
ILE A 110
TRP A  61
 None
 0.95A 1qomA-3f9kA:
undetectable		 1qomA-3f9kA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.02A 1ra3A-3f9kA:
undetectable		 1ra3A-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.07A 1ra3A-3f9kA:
undetectable		 1ra3A-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.02A 1rb3B-3f9kA:
undetectable		 1rb3B-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.02A 1rb3B-3f9kA:
undetectable		 1rb3B-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.02A 1rd7B-3f9kA:
undetectable		 1rd7B-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.02A 1tdrA-3f9kA:
undetectable		 1tdrA-3f9kA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 6 ILE A 133
VAL A 150
ILE A  84
ILE A  50
 None
 0.79A 1uwhA-3f9kA:
undetectable		 1uwhA-3f9kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 6 ILE A 133
VAL A 150
ILE A  84
ILE A  50
 None
 0.80A 1uwhB-3f9kA:
undetectable		 1uwhB-3f9kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.76A 1vptA-3f9kA:
undetectable		 1vptA-3f9kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 0.99A 2drcA-3f9kA:
undetectable		 2drcA-3f9kA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.03A 2drcA-3f9kA:
undetectable		 2drcA-3f9kA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 0.98A 2drcB-3f9kA:
undetectable		 2drcB-3f9kA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.97A 2drcB-3f9kA:
undetectable		 2drcB-3f9kA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 6 ILE A 165
ARG A 164
PRO A 196
SER A 197
 None
 1.35A 2qd3B-3f9kA:
undetectable		 2qd3B-3f9kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.00A 3drcA-3f9kA:
undetectable		 3drcA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.01A 3drcA-3f9kA:
undetectable		 3drcA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 0.98A 3drcB-3f9kA:
undetectable		 3drcB-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.96A 3drcB-3f9kA:
undetectable		 3drcB-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		3 / 3 ARG A 107
ILE A 110
TRP A  61
 None
 1.00A 3e7iB-3f9kA:
undetectable		 3e7iB-3f9kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 10 ALA A  76
GLU A  85
LEU A 101
LEU A 104
HIS A 112
 None
 1.50A 3erdB-3f9kA:
undetectable		 3erdB-3f9kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.19A 3ia4D-3f9kA:
undetectable		 3ia4D-3f9kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		3 / 3 ARG A 107
ILE A 110
TRP A  61
 None
 0.87A 3nw2A-3f9kA:
undetectable		 3nw2A-3f9kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		3 / 3 ARG A 107
ILE A 110
TRP A  61
 None
 0.92A 3nw2B-3f9kA:
undetectable		 3nw2B-3f9kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.99A 3ql0A-3f9kA:
undetectable		 3ql0A-3f9kA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 8 ASP A  64
ASP A 116
GLY A 118
GLN A 148
 MG  A 211 (-2.6A)
MG  A 211 (-2.9A)
None
None
 0.83A 3s3mA-3f9kA:
undetectable		 3s3mA-3f9kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 8 ASP A  64
ASP A 116
GLY A 118
GLU A 152
 MG  A 211 (-2.6A)
MG  A 211 (-2.9A)
None
None
 1.03A 3s3mA-3f9kA:
undetectable		 3s3mA-3f9kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 8 ASP A  64
ASP A 116
GLY A 118
GLN A 148
 MG  A 211 (-2.6A)
MG  A 211 (-2.9A)
None
None
 0.75A 3s3nA-3f9kA:
undetectable		 3s3nA-3f9kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		4 / 8 ASP A  64
ASP A 116
GLY A 118
GLU A 152
 MG  A 211 (-2.6A)
MG  A 211 (-2.9A)
None
None
 1.01A 3s3nA-3f9kA:
undetectable		 3s3nA-3f9kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.02A 4dfrA-3f9kA:
undetectable		 4dfrA-3f9kA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.04A 4ej1B-3f9kA:
undetectable		 4ej1B-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.89A 4gh8A-3f9kA:
undetectable		 4gh8A-3f9kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		6 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
ILE A 162
 None
 1.13A 4i13A-3f9kA:
undetectable		 4i13A-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 LEU A 102
LEU A  99
MET A  63
ILE A 133
ILE A 135
 None
 1.14A 4j24B-3f9kA:
undetectable		 4j24B-3f9kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 11 ILE A 165
ALA A 169
LEU A 177
LEU A 158
ILE A 162
 None
 1.19A 4p66A-3f9kA:
undetectable		 4p66A-3f9kA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.99A 4qi9B-3f9kA:
undetectable		 4qi9B-3f9kA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 11 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 1.02A 4qlfA-3f9kA:
undetectable		 4qlfA-3f9kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		6 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
ILE A 162
 None
 1.15A 4x5iA-3f9kA:
undetectable		 4x5iA-3f9kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
ILE A 162
 None
 1.10A 4x5jA-3f9kA:
undetectable		 4x5jA-3f9kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		5 / 12 ILE A 165
ALA A 169
LEU A 177
ILE A  73
LEU A 158
 None
 0.99A 5hi6A-3f9kA:
undetectable		 5hi6A-3f9kA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		3 / 3 ILE A  89
PRO A  90
ILE A  72
 None
 0.46A 5hw8F-3f9kA:
undetectable		 5hw8F-3f9kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3f9k INTEGRASE
(Human
immunodeficiency
virus
2) 		3 / 3 VAL A  79
ALA A  56
GLN A  62
 None
 0.64A 6gb9A-3f9kA:
undetectable		 6gb9A-3f9kA:
16.78