SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 11 THR A 235
LEU A  55
VAL A  59
VAL A  11
THR A  16
 None
 1.31A 1q23F-3f9rA:
undetectable		 1q23F-3f9rA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 12 LEU A   6
ILE A 202
ASP A 215
ASP A  10
GLY A 206
 None
 0.89A 1zz1B-3f9rA:
undetectable
1zz1C-3f9rA:
undetectable		 1zz1B-3f9rA:
22.07
1zz1C-3f9rA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 10 ASP A 207
SER A 129
ILE A 177
LEU A  15
GLY A  45
 None
 1.23A 2v0mA-3f9rA:
undetectable		 2v0mA-3f9rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 12 VAL A 239
THR A  42
PHE A  63
ILE A  30
PHE A   9
 None
 1.18A 2v95A-3f9rA:
undetectable		 2v95A-3f9rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 12 VAL A 239
THR A  42
PHE A  63
ILE A  30
PHE A   9
 None
 1.17A 2vdyB-3f9rA:
undetectable		 2vdyB-3f9rA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		4 / 9 PHE A  48
ALA A  49
VAL A  52
GLU A  53
 None
 0.75A 2vufA-3f9rA:
undetectable		 2vufA-3f9rA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		3 / 3 SER A 178
ASP A 180
ASN A  70
 SO4  A 247 ( 3.7A)
None
None
 0.99A 3lslA-3f9rA:
undetectable
3lslD-3f9rA:
undetectable		 3lslA-3f9rA:
22.66
3lslD-3f9rA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 11 PRO A 130
VAL A 128
TYR A 171
ILE A 111
ILE A 157
 None
 1.48A 3q5rA-3f9rA:
undetectable		 3q5rA-3f9rA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 12 VAL A 239
THR A  42
PHE A  63
ILE A  30
PHE A   9
 None
 1.16A 4c49A-3f9rA:
undetectable		 4c49A-3f9rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		4 / 7 LEU A 105
PRO A 130
GLU A 159
TYR A 171
 None
 1.03A 4lb2A-3f9rA:
undetectable		 4lb2A-3f9rA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		3 / 3 ASN A 127
SER A 178
ARG A 140
 SO4  A 247 ( 4.8A)
SO4  A 247 ( 3.7A)
SO4  A 247 (-3.6A)
 0.67A 5b2qA-3f9rA:
undetectable		 5b2qA-3f9rA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 9 ILE A 111
ARG A 151
ILE A 173
PHE A 179
VAL A 181
 None
 1.26A 5igzA-3f9rA:
undetectable		 5igzA-3f9rA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		4 / 7 LEU A   6
LEU A  72
GLY A  45
GLY A  41
 None
 0.80A 6eu9D-3f9rA:
undetectable		 6eu9D-3f9rA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		5 / 12 THR A 235
VAL A 239
ASP A  10
PHE A   9
PHE A  38
 None
 1.32A 6iblA-3f9rA:
undetectable		 6iblA-3f9rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3f9r PHOSPHOMANNOMUTASE
(Trypanosoma
brucei) 		4 / 7 GLY A 116
THR A 117
PHE A 118
SER A 178
 None
None
None
SO4  A 247 ( 3.7A)
 0.70A 6jnhA-3f9rA:
3.6		 6jnhA-3f9rA:
22.49