SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		5 / 11 TYR A  35
GLU A  25
ILE A  24
HIS A 125
LEU A  62
 None
None
None
GOL  A 146 (-4.1A)
None
 1.19A 1mrqA-3f9sA:
undetectable		 1mrqA-3f9sA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		3 / 3 TRP A  87
PHE A  71
TRP A  89
 None
GOL  A 146 ( 4.9A)
None
 1.31A 1r15C-3f9sA:
undetectable		 1r15C-3f9sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		3 / 3 TRP A  87
PHE A  71
TRP A  89
 None
GOL  A 146 ( 4.9A)
None
 1.33A 1r15F-3f9sA:
undetectable		 1r15F-3f9sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		3 / 3 TRP A  87
PHE A  71
TRP A  89
 None
GOL  A 146 ( 4.9A)
None
 1.32A 1r15G-3f9sA:
undetectable		 1r15G-3f9sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		3 / 3 TRP A  87
PHE A  71
TRP A  89
 None
GOL  A 146 ( 4.9A)
None
 1.33A 1r15H-3f9sA:
undetectable		 1r15H-3f9sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		4 / 6 LEU A  76
PHE A  77
ALA A  78
LEU A  11
 None
 0.98A 1ukbA-3f9sA:
undetectable		 1ukbA-3f9sA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		4 / 7 TYR A  35
ILE A  24
HIS A 125
LEU A  62
 None
None
GOL  A 146 (-4.1A)
None
 1.02A 4l1wA-3f9sA:
undetectable		 4l1wA-3f9sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		5 / 12 THR A 113
VAL A  18
GLN A  69
HIS A 125
TYR A 115
 GOL  A 146 ( 4.1A)
None
None
GOL  A 146 (-4.1A)
None
 0.99A 4s0vA-3f9sA:
undetectable		 4s0vA-3f9sA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		4 / 7 TYR A  35
ILE A  24
HIS A 125
LEU A  62
 None
None
GOL  A 146 (-4.1A)
None
 1.00A 4xo7A-3f9sA:
undetectable		 4xo7A-3f9sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		4 / 7 GLY A 124
TRP A 126
MET A  85
TYR A 115
 None
 1.15A 6ag0A-3f9sA:
undetectable		 6ag0A-3f9sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 3f9s PUTATIVE POLYKETIDE
CYCLASE
(Acidithiobacillu
s
ferrooxidans) 		4 / 7 GLY A 124
TRP A 126
MET A  85
TYR A 115
 None
 1.13A 6ag0C-3f9sA:
undetectable		 6ag0C-3f9sA:
18.79