SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A  58
LEU A  57
GLY A 284
ARG A 286
 None
 1.11A 1j7kA-3f9tA:
undetectable		 1j7kA-3f9tA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  99
GLY A 138
ASP A 206
ILE A 175
VAL A 127
 None
None
PLP  A 500 (-2.6A)
None
None
 1.13A 1phgA-3f9tA:
undetectable		 1phgA-3f9tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A  95
GLY A  93
VAL A  91
ASP A 242
HIS A 204
 PLP  A 500 (-3.6A)
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
None
 1.39A 2ac7A-3f9tA:
undetectable
2ac7B-3f9tA:
undetectable		 2ac7A-3f9tA:
21.57
2ac7B-3f9tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 11 HIS A 204
THR A  95
GLY A  93
VAL A  91
ASP A 242
 None
PLP  A 500 (-3.6A)
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 1.39A 2ac7A-3f9tA:
undetectable
2ac7B-3f9tA:
undetectable		 2ac7A-3f9tA:
21.57
2ac7B-3f9tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 137
ASP A 242
CYH A  38
 None
PLP  A 500 (-4.2A)
None
 1.15A 2br4F-3f9tA:
2.4		 2br4F-3f9tA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A 156
GLU A 159
GLY A 176
GLU A 190
ILE A 189
 None
 1.39A 2w98A-3f9tA:
2.2		 2w98A-3f9tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 184
GLY A 210
GLY A 179
 None
 0.42A 3bogD-3f9tA:
undetectable		 3bogD-3f9tA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 374
LEU A 212
MET A 246
ILE A 378
 None
 0.83A 3gcsA-3f9tA:
undetectable		 3gcsA-3f9tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  90
GLY A 254
ALA A 208
PRO A 252
ILE A 256
 None
None
PLP  A 500 (-3.4A)
None
None
 1.05A 3jb1A-3f9tA:
undetectable		 3jb1A-3f9tA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  81
SER A 233
PHE A 232
ILE A 239
 None
 1.01A 3ko0S-3f9tA:
undetectable		 3ko0S-3f9tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 337
ALA A 208
PHE A 209
GLY A 211
ILE A 214
 None
PLP  A 500 (-3.4A)
None
None
None
 1.22A 3qpsA-3f9tA:
undetectable		 3qpsA-3f9tA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A  90
GLY A 247
CYH A 249
HIS A 244
 None
None
None
PLP  A 500 (-4.1A)
 1.23A 3r0lD-3f9tA:
undetectable		 3r0lD-3f9tA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  99
LEU A 102
GLY A 138
ASP A 206
VAL A 127
 None
None
None
PLP  A 500 (-2.6A)
None
 1.30A 4c9nB-3f9tA:
undetectable		 4c9nB-3f9tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  99
LEU A 102
GLY A 138
ASP A 206
VAL A 127
 None
None
None
PLP  A 500 (-2.6A)
None
 1.29A 4c9pB-3f9tA:
undetectable		 4c9pB-3f9tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 214
PRO A 215
GLY A  78
ALA A 207
 None
 0.75A 4g0uB-3f9tA:
undetectable		 4g0uB-3f9tA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 166
ILE A 189
GLY A 176
ILE A 126
ILE A 125
 None
 1.01A 4iv0A-3f9tA:
undetectable		 4iv0A-3f9tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  99
GLY A 138
ASP A 206
ILE A 175
VAL A 127
 None
None
PLP  A 500 (-2.6A)
None
None
 1.13A 4jx1B-3f9tA:
undetectable		 4jx1B-3f9tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 166
ILE A 189
GLY A 176
ILE A 126
ILE A 125
 None
 0.99A 4mwzB-3f9tA:
undetectable		 4mwzB-3f9tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 187
GLU A 191
VAL A 166
ALA A 165
 None
 0.86A 4nkxA-3f9tA:
undetectable		 4nkxA-3f9tA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  94
GLY A 255
LEU A 257
SER A 253
ALA A 208
 PLP  A 500 (-3.5A)
None
None
None
PLP  A 500 (-3.4A)
 1.15A 4qtuB-3f9tA:
2.4		 4qtuB-3f9tA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A  90
GLY A 288
THR A  55
LEU A  57
LEU A  69
 None
 1.23A 5fhzB-3f9tA:
undetectable		 5fhzB-3f9tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  90
GLY A 288
THR A  55
LEU A  57
LEU A  69
 None
 1.29A 5fhzC-3f9tA:
undetectable		 5fhzC-3f9tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 288
LEU A 298
PHE A 216
ILE A 214
GLY A 211
 None
 1.23A 5fsaB-3f9tA:
undetectable		 5fsaB-3f9tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A 202
ILE A 203
ILE A 201
ILE A 126
 None
 0.93A 5murB-3f9tA:
undetectable		 5murB-3f9tA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 MET A 142
LEU A 102
TYR A 263
ASP A 237
PHE A 258
 None
 1.48A 5vlmD-3f9tA:
undetectable		 5vlmD-3f9tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 357
ILE A 389
SER A 392
 None
 0.88A 5zw2A-3f9tA:
undetectable		 5zw2A-3f9tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3f9t L-TYROSINE
DECARBOXYLASE MFNA
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 240
ILE A 239
LEU A  57
PHE A 232
TYR A  87
 None
 1.07A 6a93A-3f9tA:
undetectable		 6a93A-3f9tA:
23.61