SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 HIS A  53
GLY A  89
GLY A  90
TYR A 123
 MG  A 282 (-3.5A)
None
None
None
 0.84A 1ekjA-3fa5A:
undetectable
1ekjB-3fa5A:
undetectable		 1ekjA-3fa5A:
22.26
1ekjB-3fa5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 7 HIS A  53
GLY A  89
GLY A  90
TYR A 123
 MG  A 282 (-3.5A)
None
None
None
 0.86A 1ekjE-3fa5A:
undetectable
1ekjF-3fa5A:
undetectable		 1ekjE-3fa5A:
22.26
1ekjF-3fa5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 HIS A  53
GLY A  89
GLY A  90
TYR A 123
 MG  A 282 (-3.5A)
None
None
None
 0.86A 1ekjG-3fa5A:
undetectable
1ekjH-3fa5A:
undetectable		 1ekjG-3fa5A:
22.26
1ekjH-3fa5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 HIS A  53
SER A  18
TYR A 123
PHE A 118
 MG  A 282 (-3.5A)
None
None
None
 1.16A 1eqbA-3fa5A:
undetectable
1eqbB-3fa5A:
undetectable		 1eqbA-3fa5A:
21.91
1eqbB-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 HIS A  53
SER A  92
TYR A 123
PHE A 118
 MG  A 282 (-3.5A)
None
None
None
 1.15A 1eqbA-3fa5A:
undetectable
1eqbB-3fa5A:
undetectable		 1eqbA-3fa5A:
21.91
1eqbB-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  18
 None
None
MG  A 282 (-3.5A)
None
 1.16A 1eqbA-3fa5A:
undetectable
1eqbB-3fa5A:
undetectable		 1eqbA-3fa5A:
21.91
1eqbB-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  92
 None
None
MG  A 282 (-3.5A)
None
 1.13A 1eqbA-3fa5A:
undetectable
1eqbB-3fa5A:
undetectable		 1eqbA-3fa5A:
21.91
1eqbB-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 HIS A  53
SER A  18
TYR A 123
PHE A 118
 MG  A 282 (-3.5A)
None
None
None
 1.17A 1eqbC-3fa5A:
undetectable
1eqbD-3fa5A:
undetectable		 1eqbC-3fa5A:
21.91
1eqbD-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 HIS A  53
SER A  92
TYR A 123
PHE A 118
 MG  A 282 (-3.5A)
None
None
None
 1.15A 1eqbC-3fa5A:
undetectable
1eqbD-3fa5A:
undetectable		 1eqbC-3fa5A:
21.91
1eqbD-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  18
 None
None
MG  A 282 (-3.5A)
None
 1.18A 1eqbC-3fa5A:
undetectable
1eqbD-3fa5A:
undetectable		 1eqbC-3fa5A:
21.91
1eqbD-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  92
 None
None
MG  A 282 (-3.5A)
None
 1.14A 1eqbC-3fa5A:
undetectable
1eqbD-3fa5A:
undetectable		 1eqbC-3fa5A:
21.91
1eqbD-3fa5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		5 / 12 LEU A 278
ALA A 267
GLN A  85
HIS A 228
TYR A 171
 None
 1.28A 1kt4A-3fa5A:
undetectable		 1kt4A-3fa5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		5 / 10 THR A 231
HIS A  51
ALA A  47
ASN A 248
ALA A  42
 None
MG  A 282 (-3.4A)
None
None
None
 0.96A 1likA-3fa5A:
undetectable		 1likA-3fa5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		3 / 3 GLU A 234
HIS A  51
HIS A  53
 MG  A 282 (-2.5A)
MG  A 282 (-3.4A)
MG  A 282 (-3.5A)
 0.70A 1oe2A-3fa5A:
undetectable		 1oe2A-3fa5A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 LEU A 133
ALA A 109
GLY A  89
PHE A  68
 None
 0.80A 1sv9A-3fa5A:
undetectable		 1sv9A-3fa5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 6 PHE A 149
VAL A 175
PHE A 118
SER A  18
 None
 1.04A 1wrlB-3fa5A:
undetectable		 1wrlB-3fa5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 TYR A 123
HIS A  53
GLU A 234
HIS A  51
 None
MG  A 282 (-3.5A)
MG  A 282 (-2.5A)
MG  A 282 (-3.4A)
 0.95A 2bnnA-3fa5A:
undetectable
2bnnB-3fa5A:
undetectable		 2bnnA-3fa5A:
22.42
2bnnB-3fa5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 5 ALA A 245
ALA A  42
ALA A  47
GLN A 215
 None
 0.92A 2nyrB-3fa5A:
undetectable		 2nyrB-3fa5A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 5 GLY A  89
GLY A  90
PHE A 149
PHE A 118
 None
 1.06A 2qr2A-3fa5A:
undetectable
2qr2B-3fa5A:
undetectable		 2qr2A-3fa5A:
23.31
2qr2B-3fa5A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 TYR A 123
SER A 112
HIS A  51
SER A 110
 None
None
MG  A 282 (-3.4A)
None
 1.30A 2vmyA-3fa5A:
2.0
2vmyB-3fa5A:
2.1		 2vmyA-3fa5A:
21.45
2vmyB-3fa5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		5 / 12 VAL A 175
LEU A  19
SER A 110
SER A 112
TYR A 123
 None
 1.48A 3apvA-3fa5A:
undetectable		 3apvA-3fa5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 5 SER A  38
ARG A 254
GLY A 253
GLU A 257
 None
 1.16A 3k9fA-3fa5A:
undetectable
3k9fB-3fa5A:
undetectable
3k9fC-3fa5A:
undetectable		 3k9fA-3fa5A:
21.44
3k9fB-3fa5A:
21.44
3k9fC-3fa5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 6 SER A  38
ARG A 254
GLY A 253
GLU A 257
 None
 1.16A 3k9fA-3fa5A:
undetectable
3k9fB-3fa5A:
undetectable
3k9fD-3fa5A:
undetectable		 3k9fA-3fa5A:
21.44
3k9fB-3fa5A:
21.44
3k9fD-3fa5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 6 ARG A  55
ASP A 235
GLN A 215
GLU A 145
 None
 1.35A 4azvA-3fa5A:
undetectable		 4azvA-3fa5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 6 SER A 110
GLU A 145
GLN A  85
THR A  16
 None
 1.29A 4lnxA-3fa5A:
undetectable		 4lnxA-3fa5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 5 ARG A 254
GLY A 253
GLU A 257
SER A  38
 None
 1.11A 4z3oA-3fa5A:
undetectable
4z3oB-3fa5A:
undetectable		 4z3oA-3fa5A:
17.16
4z3oB-3fa5A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 8 ASN A 248
ALA A 249
VAL A 252
GLU A  44
 None
 0.80A 4zbqA-3fa5A:
undetectable		 4zbqA-3fa5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		4 / 7 ARG A  91
ARG A 230
ASP A 235
ILE A 211
 CL  A 285 (-4.0A)
MG  A 282 ( 3.8A)
None
None
 0.87A 5a06B-3fa5A:
undetectable		 5a06B-3fa5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)
(Paracoccus
denitrificans) 		5 / 9 GLY A 177
ILE A 154
LEU A 151
ARG A 186
ASP A 190
 None
 1.18A 6c2mC-3fa5A:
undetectable		 6c2mC-3fa5A:
15.00