SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 7 LEU A 477
ALA A 471
PHE A 469
VAL A 352
VAL A 354
None
1.18A 1epbA-3fahA:
undetectable
1epbA-3fahA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 6 LEU A 446
THR A 440
ALA A 436
LEU A 432
None
1.21A 1etb2-3fahA:
undetectable
1etb2-3fahA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 LEU A 432
LEU A 284
MET A 212
ILE A 251
VAL A 300
None
1.35A 1hrkB-3fahA:
undetectable
1hrkB-3fahA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 ASN A 157
LEU A 115
ALA A 111
LEU A 114
None
1.01A 1hwiB-3fahA:
undetectable
1hwiB-3fahA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 ASN A 157
LEU A 115
ALA A 111
LEU A 114
None
1.00A 1hwiC-3fahA:
undetectable
1hwiC-3fahA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 ARG A 123
ASP A 805
ASN A 800
None
0.81A 1nbhA-3fahA:
undetectable
1nbhA-3fahA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 ARG A 123
ASP A 805
ASN A 800
None
0.80A 1nbhD-3fahA:
undetectable
1nbhD-3fahA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 GLY A 279
GLN A 455
VAL A 527
SER A 218
None
1.40A 1p6kB-3fahA:
undetectable
1p6kB-3fahA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 THR A 420
GLY A 422
HIS A 365
LEU A 432
VAL A 433
PCD  A 921 (-4.2A)
PCD  A 921 (-3.4A)
None
None
None
1.08A 1r30B-3fahA:
undetectable
1r30B-3fahA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 GLY A 279
GLN A 455
VAL A 527
SER A 218
None
1.38A 1rs6B-3fahA:
undetectable
1rs6B-3fahA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 11 ALA A 657
THR A 689
PRO A 690
PRO A 861
ALA A 864
None
None
None
None
PCD  A 921 ( 3.7A)
1.10A 1rv7A-3fahA:
undetectable
1rv7B-3fahA:
undetectable
1rv7A-3fahA:
8.12
1rv7B-3fahA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 10 SER A 429
VAL A 433
ALA A 373
HIS A 445
TYR A 448
None
1.46A 1td2A-3fahA:
undetectable
1td2A-3fahA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 7 LEU A 818
GLN A 814
LEU A 894
PHE A 542
None
1.08A 1v55C-3fahA:
undetectable
1v55J-3fahA:
undetectable
1v55C-3fahA:
13.90
1v55J-3fahA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 ALA A 877
PHE A 542
ASN A 881
ASP A 549
None
1.11A 1yc2D-3fahA:
undetectable
1yc2D-3fahA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 GLY A 279
GLN A 455
VAL A 527
SER A 218
None
1.40A 1zzuB-3fahA:
undetectable
1zzuB-3fahA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 THR A 524
GLY A 489
GLY A 529
GLU A 493
ILE A 324
None
1.23A 2akeA-3fahA:
undetectable
2akeA-3fahA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 THR A 524
GLY A 489
GLY A 529
ILE A 324
GLN A 277
None
1.39A 2akeA-3fahA:
undetectable
2akeA-3fahA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 THR A 524
GLY A 489
GLY A 529
GLU A 493
ILE A 324
None
1.21A 2azxA-3fahA:
undetectable
2azxA-3fahA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 THR A 524
GLY A 489
GLY A 529
GLU A 493
ILE A 324
None
1.27A 2azxB-3fahA:
undetectable
2azxB-3fahA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 6 VAL A  56
SER A  49
LEU A 114
PHE A 107
None
1.32A 2f8dA-3fahA:
undetectable
2f8dA-3fahA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 LEU A 446
VAL A 433
VAL A 435
ILE A 269
MET A 212
None
1.19A 2gj5A-3fahA:
undetectable
2gj5A-3fahA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 ASN A 714
ILE A 644
MET A 672
None
0.85A 2h42C-3fahA:
undetectable
2h42C-3fahA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 7 GLY A 696
GLY A 697
ASP A 630
SER A 695
GOL  A 912 ( 3.1A)
GOL  A 912 ( 3.1A)
None
PCD  A 921 (-4.4A)
0.83A 2oa1B-3fahA:
undetectable
2oa1B-3fahA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 GLY A 577
ASN A 574
ALA A 503
GLN A 504
GLN A 335
None
1.01A 2pkkA-3fahA:
undetectable
2pkkA-3fahA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 6 PHE A 505
TYR A 622
TRP A 463
ARG A 460
None
GOL  A 912 (-4.5A)
None
CL  A 916 (-4.4A)
1.27A 2x2iB-3fahA:
0.0
2x2iB-3fahA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 TRP A 463
VAL A 522
TRP A 484
None
0.96A 2xdcC-3fahA:
undetectable
2xdcD-3fahA:
undetectable
2xdcC-3fahA:
1.49
2xdcD-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 TRP A 463
VAL A 522
TRP A 484
None
0.92A 2xdcE-3fahA:
undetectable
2xdcF-3fahA:
undetectable
2xdcE-3fahA:
1.49
2xdcF-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 TRP A 463
VAL A 522
TRP A 484
None
0.95A 2y5mE-3fahA:
undetectable
2y5mF-3fahA:
undetectable
2y5mE-3fahA:
1.49
2y5mF-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 TRP A 463
VAL A 522
TRP A 484
None
0.95A 2y6nC-3fahA:
undetectable
2y6nD-3fahA:
undetectable
2y6nC-3fahA:
1.49
2y6nD-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 TRP A 463
VAL A 522
TRP A 484
None
0.96A 2y6nE-3fahA:
undetectable
2y6nF-3fahA:
undetectable
2y6nE-3fahA:
1.49
2y6nF-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 11 GLY A 866
GLN A 655
THR A 704
ARG A 533
GLY A 697
PCD  A 921 (-3.4A)
PCD  A 921 (-3.6A)
None
PCD  A 921 (-4.0A)
GOL  A 912 ( 3.1A)
1.36A 2zxwA-3fahA:
undetectable
2zxwB-3fahA:
undetectable
2zxwT-3fahA:
undetectable
2zxwA-3fahA:
21.15
2zxwB-3fahA:
13.55
2zxwT-3fahA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 11 ARG A 533
GLY A 697
GLY A 866
GLN A 655
THR A 704
PCD  A 921 (-4.0A)
GOL  A 912 ( 3.1A)
PCD  A 921 (-3.4A)
PCD  A 921 (-3.6A)
None
1.34A 2zxwG-3fahA:
undetectable
2zxwN-3fahA:
undetectable
2zxwO-3fahA:
undetectable
2zxwG-3fahA:
7.02
2zxwN-3fahA:
21.15
2zxwO-3fahA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 11 ARG A 533
PHE A 421
GLY A 422
GLY A 697
GLN A 655
PCD  A 921 (-4.0A)
PCD  A 921 (-3.4A)
PCD  A 921 (-3.4A)
GOL  A 912 ( 3.1A)
PCD  A 921 (-3.6A)
1.06A 3ag3G-3fahA:
undetectable
3ag3N-3fahA:
undetectable
3ag3O-3fahA:
undetectable
3ag3G-3fahA:
7.02
3ag3N-3fahA:
21.15
3ag3O-3fahA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 LEU A 145
PRO A 871
GLY A 806
GLY A  97
CYH A 139
None
None
None
None
FES  A 908 ( 2.4A)
1.01A 3e23A-3fahA:
undetectable
3e23A-3fahA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 10 ALA A  59
VAL A  26
ALA A  71
ILE A   6
LEU A  15
None
1.10A 3fl9F-3fahA:
undetectable
3fl9F-3fahA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 4 PRO A 676
TYR A 180
GLY A 663
THR A 664
None
0.97A 3ib0A-3fahA:
undetectable
3ib0A-3fahA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 ARG A 569
ARG A 563
GLY A 509
GLU A 545
None
1.31A 3k9fA-3fahA:
undetectable
3k9fB-3fahA:
undetectable
3k9fC-3fahA:
undetectable
3k9fA-3fahA:
20.41
3k9fB-3fahA:
20.41
3k9fC-3fahA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLY A 191
CYH A  45
CYH A 137
PHE A 421
None
FES  A 909 (-2.3A)
FES  A 908 (-2.3A)
PCD  A 921 (-3.4A)
1.08A 3ko0D-3fahA:
undetectable
3ko0E-3fahA:
undetectable
3ko0D-3fahA:
7.39
3ko0E-3fahA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLY A 191
CYH A  45
CYH A 137
PHE A 421
None
FES  A 909 (-2.3A)
FES  A 908 (-2.3A)
PCD  A 921 (-3.4A)
1.04A 3ko0B-3fahA:
1.0
3ko0J-3fahA:
undetectable
3ko0B-3fahA:
7.39
3ko0J-3fahA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLU A 545
SER A 544
MET A 548
VAL A 467
None
1.36A 3nlyA-3fahA:
undetectable
3nlyB-3fahA:
undetectable
3nlyA-3fahA:
17.52
3nlyB-3fahA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 6 GLY A 191
LEU A 193
GLU A  77
ASP A 198
None
0.93A 3ps9A-3fahA:
undetectable
3ps9A-3fahA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLU A 545
SER A 544
MET A 548
VAL A 467
None
1.34A 3rqlA-3fahA:
undetectable
3rqlB-3fahA:
undetectable
3rqlA-3fahA:
17.52
3rqlB-3fahA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 4 ASP A 198
ASP A 194
GLY A 191
THR A 184
None
0.90A 3tl9B-3fahA:
undetectable
3tl9B-3fahA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 THR A 521
ARG A 520
GLY A 502
SER A 482
None
0.95A 3tzfB-3fahA:
undetectable
3tzfB-3fahA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 PHE A 494
GLY A 495
GLY A 422
MET A 398
None
None
PCD  A 921 (-3.4A)
None
0.95A 3v3nB-3fahA:
undetectable
3v3nB-3fahA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 PHE A 494
GLY A 495
GLY A 422
MET A 398
None
None
PCD  A 921 (-3.4A)
None
0.95A 3v3nC-3fahA:
undetectable
3v3nC-3fahA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 7 ALA A 877
ILE A 879
ARG A 890
GLY A 616
None
0.94A 3v4tH-3fahA:
undetectable
3v4tH-3fahA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 LEU A 432
LEU A 284
MET A 212
ILE A 251
VAL A 300
None
1.32A 3w1wA-3fahA:
undetectable
3w1wA-3fahA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 TYR A 766
TYR A 768
TYR A 568
MET A 541
None
1.48A 3wipD-3fahA:
undetectable
3wipE-3fahA:
undetectable
3wipD-3fahA:
13.41
3wipE-3fahA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 TRP A 463
VAL A 522
TRP A 484
None
1.15A 3zq8A-3fahA:
undetectable
3zq8B-3fahA:
undetectable
3zq8A-3fahA:
1.49
3zq8B-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 HIS A 653
GLY A 422
TYR A 423
GLU A 369
PCD  A 921 (-3.7A)
PCD  A 921 (-3.4A)
None
None
1.27A 4ae1B-3fahA:
undetectable
4ae1B-3fahA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 10 ILE A 808
LEU A 791
GLY A 868
GLY A 866
SER A 865
None
None
PCD  A 921 (-3.5A)
PCD  A 921 (-3.4A)
PCD  A 921 (-4.9A)
1.24A 4bwlC-3fahA:
undetectable
4bwlC-3fahA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLU A 545
SER A 544
MET A 548
VAL A 467
None
1.38A 4capA-3fahA:
undetectable
4capB-3fahA:
undetectable
4capA-3fahA:
17.52
4capB-3fahA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLU A 545
SER A 544
MET A 548
VAL A 467
None
1.34A 4d32A-3fahA:
undetectable
4d32B-3fahA:
undetectable
4d32A-3fahA:
17.52
4d32B-3fahA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 9 ALA A 537
ALA A 508
GLY A 507
ILE A 619
GLY A 620
None
1.12A 4eatB-3fahA:
2.4
4eatB-3fahA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 7 SER A 429
TYR A 448
MET A 212
LEU A 284
None
1.25A 4hxyB-3fahA:
undetectable
4hxyB-3fahA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 11 GLY A 660
ARG A 709
ALA A 707
PRO A 183
ILE A 679
PCD  A 921 (-3.1A)
None
None
None
None
1.18A 4j4vA-3fahA:
undetectable
4j4vA-3fahA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 9 TYR A 535
HIS A 488
PHE A 494
ILE A 390
GOL  A 912 ( 4.1A)
None
None
None
1.36A 4jvlA-3fahA:
undetectable
4jvlA-3fahA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 9 ALA A 375
ALA A 434
ALA A 431
ALA A 373
SER A 387
None
1.28A 4twdA-3fahA:
undetectable
4twdB-3fahA:
undetectable
4twdC-3fahA:
undetectable
4twdD-3fahA:
undetectable
4twdE-3fahA:
undetectable
4twdA-3fahA:
15.46
4twdB-3fahA:
15.46
4twdC-3fahA:
15.46
4twdD-3fahA:
15.46
4twdE-3fahA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 GLY A 519
PHE A 333
ALA A 503
GLN A 335
GLN A 504
None
1.18A 4ubeA-3fahA:
undetectable
4ubeA-3fahA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 GLY A 577
ASN A 574
ALA A 503
GLN A 504
GLN A 335
None
1.00A 4ubeA-3fahA:
undetectable
4ubeA-3fahA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 GLU A 545
SER A 544
MET A 548
VAL A 467
None
1.35A 4v3yA-3fahA:
undetectable
4v3yB-3fahA:
undetectable
4v3yA-3fahA:
17.52
4v3yB-3fahA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 VAL A  38
ALA A 197
PHE A 102
FES  A 909 ( 3.7A)
None
None
0.92A 4w5nA-3fahA:
undetectable
4w5nA-3fahA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 9 LEU A  85
ILE A  76
SER A 104
VAL A 186
THR A 190
None
None
FES  A 908 ( 4.7A)
None
None
1.30A 4x3mA-3fahA:
undetectable
4x3mA-3fahA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 11 GLY A 697
GLN A 655
ARG A 533
PHE A 421
GLY A 422
GOL  A 912 ( 3.1A)
PCD  A 921 (-3.6A)
PCD  A 921 (-4.0A)
PCD  A 921 (-3.4A)
PCD  A 921 (-3.4A)
1.19A 5b1bA-3fahA:
0.0
5b1bB-3fahA:
0.0
5b1bT-3fahA:
0.0
5b1bA-3fahA:
21.15
5b1bB-3fahA:
13.55
5b1bT-3fahA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 6 SER A 692
GLU A 633
GLY A 656
GLY A 660
None
None
PCD  A 921 (-3.2A)
PCD  A 921 (-3.1A)
0.76A 5cdnA-3fahA:
undetectable
5cdnB-3fahA:
undetectable
5cdnA-3fahA:
20.05
5cdnB-3fahA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 THR A 428
CYH A 281
TYR A 456
LEU A 432
None
1.20A 5kxiA-3fahA:
undetectable
5kxiB-3fahA:
undetectable
5kxiA-3fahA:
17.44
5kxiB-3fahA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 THR A 428
CYH A 281
TYR A 456
LEU A 432
None
1.25A 5kxiD-3fahA:
undetectable
5kxiE-3fahA:
undetectable
5kxiD-3fahA:
17.44
5kxiE-3fahA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 TYR A 450
ILE A 844
LEU A 820
SER A 821
GLU A 822
None
1.30A 5l8oB-3fahA:
undetectable
5l8oB-3fahA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 10 ASP A 198
LEU A 446
ALA A 373
THR A 457
GLY A 418
None
1.25A 5m5cE-3fahA:
undetectable
5m5cE-3fahA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
3 / 3 VAL A  93
LYS A 168
MET A 169
None
1.02A 5nknA-3fahA:
undetectable
5nknA-3fahA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 10 ALA A  21
VAL A  17
ILE A   6
ILE A  73
GLN A  30
None
0.98A 5nukA-3fahA:
undetectable
5nukA-3fahA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 VAL A  50
LEU A 201
ASP A  25
ARG A 447
PRO A 105
None
1.27A 5syfB-3fahA:
undetectable
5syfB-3fahA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 12 ILE A  76
VAL A  50
ALA A 197
GLY A 196
TYR A 195
None
1.13A 5uxdB-3fahA:
undetectable
5uxdB-3fahA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 5 VAL A  17
LEU A  31
VAL A  36
LEU A 201
None
1.02A 6bqgA-3fahA:
undetectable
6bqgA-3fahA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 THR A 343
THR A 353
LYS A 554
SER A 349
None
1.12A 6c06C-3fahA:
undetectable
6c06C-3fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 THR A 428
CYH A 281
TYR A 456
LEU A 446
None
1.08A 6cnjD-3fahA:
undetectable
6cnjE-3fahA:
undetectable
6cnjD-3fahA:
6.01
6cnjE-3fahA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
5 / 9 VAL A 486
LEU A 497
GLY A 502
GLN A 539
THR A 521
None
None
None
CL  A 916 (-3.6A)
None
1.20A 6czmB-3fahA:
undetectable
6czmC-3fahA:
undetectable
6czmB-3fahA:
19.14
6czmC-3fahA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas)
4 / 8 ASP A 483
ARG A 520
GLU A 334
GLU A 319
None
1.20A 6mn4B-3fahA:
undetectable
6mn4B-3fahA:
16.44