SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 9 THR A 115
ILE A 201
GLY A 200
GLY A 220
ILE A 222
 None
None
CL  A   4 (-3.6A)
None
CL  A   4 (-4.8A)
 1.39A 2y7wA-3faiA:
undetectable		 2y7wA-3faiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 10 THR A 115
ILE A 201
GLY A 200
GLY A 220
ILE A 222
 None
None
CL  A   4 (-3.6A)
None
CL  A   4 (-4.8A)
 1.39A 2y7wB-3faiA:
undetectable		 2y7wB-3faiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		3 / 3 TYR A 191
ASP A 179
ASP A 177
 None
GOL  A 319 ( 3.8A)
SO4  A 315 (-4.3A)
 0.96A 3ou7B-3faiA:
undetectable		 3ou7B-3faiA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 12 ILE A 131
TRP A 128
VAL A 112
LEU A 182
ILE A  99
 None
None
None
GOL  A 318 (-4.6A)
None
 1.09A 3w68C-3faiA:
2.7		 3w68C-3faiA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 9 HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 0.60A 4c1dA-3faiA:
29.4		 4c1dA-3faiA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 9 TRP A  87
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 1.27A 4c1dA-3faiA:
29.4		 4c1dA-3faiA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 10 ASP A 120
HIS A 196
CYH A 221
ASN A 233
HIS A 263
 ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
None
ZN  A   1 ( 3.2A)
 0.84A 4c1dB-3faiA:
29.5		 4c1dB-3faiA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 10 HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 0.61A 4c1dB-3faiA:
29.5		 4c1dB-3faiA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 10 TRP A  87
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 1.25A 4c1dB-3faiA:
29.5		 4c1dB-3faiA:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		6 / 11 ASP A 120
HIS A 196
CYH A 221
LYS A 224
ASN A 233
HIS A 263
 ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
SO4  A 311 ( 4.7A)
None
ZN  A   1 ( 3.2A)
 0.92A 4c1fA-3faiA:
29.6
4c1fB-3faiA:
28.8		 4c1fA-3faiA:
27.24
4c1fB-3faiA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		6 / 11 HIS A 118
ASP A 120
HIS A 196
CYH A 221
LYS A 224
HIS A 263
 ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
SO4  A 311 ( 4.7A)
ZN  A   1 ( 3.2A)
 1.05A 4c1fA-3faiA:
29.6
4c1fB-3faiA:
28.8		 4c1fA-3faiA:
27.24
4c1fB-3faiA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		7 / 9 TRP A  87
ASP A 120
HIS A 196
CYH A 221
GLY A 232
ASN A 233
HIS A 263
 None
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
GOL  A 320 (-3.5A)
None
ZN  A   1 ( 3.2A)
 0.75A 4c1hA-3faiA:
29.3		 4c1hA-3faiA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		7 / 9 TRP A  87
HIS A 118
ASP A 120
HIS A 196
CYH A 221
ASN A 233
HIS A 263
 None
ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
None
ZN  A   1 ( 3.2A)
 0.93A 4c1hA-3faiA:
29.3		 4c1hA-3faiA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 8 HIS A 263
GLU A  56
ARG A 121
ILE A 260
 ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.6A)
None
 1.20A 4cx7A-3faiA:
undetectable
4cx7B-3faiA:
undetectable		 4cx7A-3faiA:
20.56
4cx7B-3faiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		8 / 9 VAL A  67
TRP A  87
HIS A 118
ASP A 120
HIS A 196
CYH A 221
ASN A 233
HIS A 263
 None
None
ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
None
ZN  A   1 ( 3.2A)
 0.65A 4exsA-3faiA:
12.8		 4exsA-3faiA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		7 / 8 VAL A  67
TRP A  87
ASP A 120
HIS A 196
CYH A 221
ASN A 233
HIS A 263
 None
None
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
None
ZN  A   1 ( 3.2A)
 0.70A 4exsB-3faiA:
27.8		 4exsB-3faiA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		7 / 8 VAL A  67
TRP A  87
HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
None
ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 0.56A 4exsB-3faiA:
27.8		 4exsB-3faiA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 7 TRP A  87
GLY A 262
GLY A 220
ASN A 116
 None
None
None
CL  A   4 (-4.1A)
 0.97A 4fgkB-3faiA:
undetectable		 4fgkB-3faiA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 12 GLU A 298
GLY A 219
PHE A 202
ILE A 256
ARG A 248
 None
 1.10A 4hytC-3faiA:
undetectable		 4hytC-3faiA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 7 VAL A 112
TRP A 128
ILE A 131
LEU A  45
 None
 1.08A 4xo7B-3faiA:
undetectable		 4xo7B-3faiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		7 / 8 VAL A  67
TRP A  87
HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
None
ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 0.58A 5a5zA-3faiA:
27.3		 5a5zA-3faiA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 8 VAL A  67
TRP A  87
HIS A 196
ASN A 233
HIS A 263
 None
None
ZN  A   2 ( 3.2A)
None
ZN  A   1 ( 3.2A)
 1.03A 5a5zA-3faiA:
27.3		 5a5zA-3faiA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 7 HIS A 196
CYH A 221
LYS A 224
GLY A 232
HIS A 263
 ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
SO4  A 311 ( 4.7A)
GOL  A 320 (-3.5A)
ZN  A   1 ( 3.2A)
 0.75A 5a5zC-3faiA:
27.5		 5a5zC-3faiA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 7 HIS A 196
LYS A 224
GLY A 232
ASN A 233
 ZN  A   2 ( 3.2A)
SO4  A 311 ( 4.7A)
GOL  A 320 (-3.5A)
None
 0.80A 5a5zC-3faiA:
27.5		 5a5zC-3faiA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		5 / 12 GLY A 290
GLY A 219
GLY A 261
GLU A 225
ILE A 222
 CL  A 310 (-4.5A)
None
None
None
CL  A   4 (-4.8A)
 1.01A 5ehiA-3faiA:
undetectable		 5ehiA-3faiA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		6 / 8 TRP A  87
HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
ZN  A   2 ( 3.1A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
ZN  A   1 ( 3.2A)
 0.55A 5zj8A-3faiA:
12.8		 5zj8A-3faiA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 8 LEU A 161
TYR A  60
THR A 157
TRP A  87
 None
 1.21A 6c71B-3faiA:
undetectable		 6c71B-3faiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 8 LEU A 217
LEU A 254
GLY A 193
ARG A 248
 None
 0.95A 6ce2A-3faiA:
undetectable		 6ce2A-3faiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3fai BETA-LACTAMASE
(Aeromonas
hydrophila) 		4 / 5 ASN A  70
GLY A 232
HIS A 263
ASP A 120
 None
GOL  A 320 (-3.5A)
ZN  A   1 ( 3.2A)
ZN  A   1 ( 2.5A)
 1.02A 6gh9A-3faiA:
undetectable		 6gh9A-3faiA:
17.59