SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 7 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.63A 1c9sT-3faoA:
undetectable
1c9sU-3faoA:
undetectable
1c9sT-3faoA:
18.44
1c9sU-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 7 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.63A 1gtfL-3faoA:
undetectable
1gtfM-3faoA:
undetectable
1gtfL-3faoA:
18.44
1gtfM-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.63A 1gtfN-3faoA:
undetectable
1gtfO-3faoA:
undetectable
1gtfN-3faoA:
18.44
1gtfO-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.59A 1gtnA-3faoA:
undetectable
1gtnB-3faoA:
undetectable
1gtnA-3faoA:
18.44
1gtnB-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 ALA A  38
GLY A 149
ALA A  66
THR A 134
THR A 145
None
1.18A 1gtnB-3faoA:
undetectable
1gtnC-3faoA:
undetectable
1gtnB-3faoA:
18.44
1gtnC-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 ALA A  38
GLY A 149
ALA A  66
THR A 134
THR A 145
None
1.17A 1gtnH-3faoA:
undetectable
1gtnI-3faoA:
undetectable
1gtnH-3faoA:
18.44
1gtnI-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.65A 1gtnP-3faoA:
undetectable
1gtnQ-3faoA:
undetectable
1gtnP-3faoA:
18.44
1gtnQ-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.62A 1utdB-3faoA:
undetectable
1utdC-3faoA:
undetectable
1utdB-3faoA:
18.44
1utdC-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 1utdF-3faoA:
undetectable
1utdG-3faoA:
undetectable
1utdF-3faoA:
18.44
1utdG-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.63A 1utdJ-3faoA:
undetectable
1utdK-3faoA:
undetectable
1utdJ-3faoA:
18.44
1utdK-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 GLY A 149
ALA A  66
THR A 134
THR A 145
ALA A  38
None
1.19A 1utdT-3faoA:
undetectable
1utdU-3faoA:
undetectable
1utdT-3faoA:
18.44
1utdU-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 12 GLY A 102
ALA A  91
VAL A 130
GLY A 105
VAL A 122
None
0.92A 2ieoB-3faoA:
undetectable
2ieoB-3faoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 7 GLY A 116
PHE A 165
PHE A 166
PHE A 112
None
1.14A 3ko0L-3faoA:
undetectable
3ko0N-3faoA:
undetectable
3ko0L-3faoA:
17.71
3ko0N-3faoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 VAL A  13
VAL A  15
GLY A  23
VAL A  35
GLY A 119
None
1.05A 3ls4H-3faoA:
undetectable
3ls4H-3faoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 11 GLY A  23
ALA A  37
GLY A 119
VAL A  15
HIS A  39
None
None
None
None
PO4  A 205 (-4.0A)
1.43A 4c5lA-3faoA:
undetectable
4c5lA-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 11 GLY A  23
ALA A 118
GLY A 119
VAL A  15
HIS A  39
None
PO4  A 205 ( 3.8A)
None
None
PO4  A 205 (-4.0A)
1.30A 4c5lA-3faoA:
undetectable
4c5lA-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 9 GLY A  23
ALA A 118
GLY A 119
VAL A  15
HIS A  39
None
PO4  A 205 ( 3.8A)
None
None
PO4  A 205 (-4.0A)
1.29A 4c5lB-3faoA:
undetectable
4c5lB-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 GLY A  23
ALA A  37
GLY A 119
VAL A  15
HIS A  39
None
None
None
None
PO4  A 205 (-4.0A)
1.38A 4c5lC-3faoA:
undetectable
4c5lC-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 GLY A  23
ALA A 118
GLY A 119
VAL A  15
HIS A  39
None
PO4  A 205 ( 3.8A)
None
None
PO4  A 205 (-4.0A)
1.34A 4c5lC-3faoA:
undetectable
4c5lC-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 GLY A  23
ALA A 118
GLY A 119
VAL A  15
HIS A  39
None
PO4  A 205 ( 3.8A)
None
None
PO4  A 205 (-4.0A)
1.29A 4c5nB-3faoA:
undetectable
4c5nB-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 ALA A  38
GLY A 149
ALA A  66
THR A 134
THR A 145
None
1.17A 5eevF-3faoA:
undetectable
5eevG-3faoA:
undetectable
5eevF-3faoA:
18.44
5eevG-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 5eevL-3faoA:
undetectable
5eevV-3faoA:
undetectable
5eevL-3faoA:
18.44
5eevV-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 5eewL-3faoA:
undetectable
5eewV-3faoA:
undetectable
5eewL-3faoA:
18.44
5eewV-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 ALA A  38
GLY A 149
ALA A  66
THR A 134
THR A 145
None
1.17A 5eexF-3faoA:
undetectable
5eexG-3faoA:
undetectable
5eexF-3faoA:
18.44
5eexG-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 ALA A  38
GLY A 149
ALA A  66
THR A 134
THR A 145
None
1.18A 5eezF-3faoA:
undetectable
5eezG-3faoA:
undetectable
5eezF-3faoA:
18.44
5eezG-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 5eezL-3faoA:
undetectable
5eezV-3faoA:
undetectable
5eezL-3faoA:
18.44
5eezV-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 10 ALA A  38
GLY A 149
ALA A  66
THR A 134
THR A 145
None
1.18A 5ef1F-3faoA:
undetectable
5ef1G-3faoA:
undetectable
5ef1F-3faoA:
18.44
5ef1G-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 5ef1L-3faoA:
undetectable
5ef1V-3faoA:
undetectable
5ef1L-3faoA:
18.44
5ef1V-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 5ef2L-3faoA:
undetectable
5ef2V-3faoA:
undetectable
5ef2L-3faoA:
18.44
5ef2V-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
4 / 8 GLY A 149
ALA A  38
THR A 134
THR A 145
None
0.64A 5ef3L-3faoA:
undetectable
5ef3V-3faoA:
undetectable
5ef3L-3faoA:
18.44
5ef3V-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
5 / 9 VAL A 103
GLY A 105
LEU A 159
LYS A 158
ARG A  90
None
0.96A 6c2mC-3faoA:
8.6
6c2mC-3faoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and
respiratory
syndrome
virus)
3 / 3 PHE A 112
ARG A  90
ALA A 195
None
0.80A 6ecfB-3faoA:
undetectable
6ecfB-3faoA:
21.34