SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		3 / 3 GLN A1313
HIS A1325
PRO A1318
 None
 0.88A 1d8cA-3fayA:
undetectable		 1d8cA-3fayA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		4 / 8 GLU A1326
ASP A1322
ILE A1324
LEU A 978
 None
 0.78A 1hmyA-3fayA:
undetectable		 1hmyA-3fayA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		4 / 5 LEU A1072
PRO A1198
ALA A1199
ILE A1200
 None
 0.99A 2aofB-3fayA:
undetectable		 2aofB-3fayA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 12 LEU A1190
ASN A1189
LEU A1191
VAL A1166
LEU A1030
 None
 1.41A 2q7kA-3fayA:
undetectable		 2q7kA-3fayA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 12 PHE A1058
ALA A1013
TYR A1158
VAL A1272
LEU A1023
 None
 1.39A 2rctA-3fayA:
undetectable		 2rctA-3fayA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		3 / 3 PRO A1157
GLY A1064
TYR A1195
 None
 0.73A 2vouC-3fayA:
undetectable		 2vouC-3fayA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 12 LEU A1030
GLY A1159
VAL A1153
LEU A1191
PHE A1265
 None
 1.15A 2zzmA-3fayA:
undetectable		 2zzmA-3fayA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		4 / 6 ASP A1132
ARG A1136
ILE A1094
ARG A1130
 None
 1.41A 3ckzA-3fayA:
undetectable		 3ckzA-3fayA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 10 ILE A1149
GLY A1188
ILE A1187
VAL A1153
VAL A1150
 None
 0.92A 4j5jB-3fayA:
undetectable		 4j5jB-3fayA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		3 / 3 LYS A1088
LYS A1096
SER A1097
 None
 1.38A 5odiA-3fayA:
undetectable		 5odiA-3fayA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 12 PHE A1262
PHE A1265
ILE A1209
ILE A1228
ALA A1229
 None
 1.12A 5vc0A-3fayA:
undetectable		 5vc0A-3fayA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 10 PRO A1157
ALA A1164
GLY A1188
ILE A1187
ALA A1269
 None
 0.85A 5vyhA-3fayA:
undetectable		 5vyhA-3fayA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		5 / 12 ASN A1197
ILE A1200
ILE A1156
PHE A1266
PHE A1262
 None
 1.41A 6j20A-3fayA:
undetectable		 6j20A-3fayA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens) 		4 / 8 GLY A1188
LEU A1191
ALA A1164
LYS A1165
 None
 0.61A 6mdqA-3fayA:
undetectable		 6mdqA-3fayA:
11.52