SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 12 THR A 129
PHE A 138
LEU A 152
VAL A 176
ALA A 158
 None
 1.34A 1q23A-3fbgA:
undetectable
1q23B-3fbgA:
undetectable		 1q23A-3fbgA:
18.99
1q23B-3fbgA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ARG A 272
TYR A 218
ASN A 147
GLU A 132
 None
 1.03A 1rjdA-3fbgA:
4.5		 1rjdA-3fbgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ARG A 272
TYR A 218
ASN A 147
GLU A 132
 None
 1.03A 1rjdB-3fbgA:
4.5		 1rjdB-3fbgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ARG A 272
TYR A 218
ASN A 147
GLU A 132
 None
 1.07A 1rjdC-3fbgA:
4.4		 1rjdC-3fbgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 7 ASP A 279
ASP A 278
LYS A 282
HIS A 283
 None
 1.48A 1t03A-3fbgA:
undetectable		 1t03A-3fbgA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 10 THR A 189
GLY A 159
GLY A 329
ILE A 186
ALA A 180
 None
 1.10A 1x7pA-3fbgA:
2.8
1x7pB-3fbgA:
3.0		 1x7pA-3fbgA:
23.14
1x7pB-3fbgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 11 ILE A 328
GLY A 193
ALA A 194
ASP A 195
ILE A 168
 None
 0.91A 2fxdA-3fbgA:
undetectable		 2fxdA-3fbgA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 12 THR A 277
HIS A 241
ALA A 271
VAL A 137
TYR A 286
 None
 1.31A 2g72B-3fbgA:
5.3		 2g72B-3fbgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 9 VAL A 121
THR A 303
VAL A 306
ILE A 333
VAL A 332
 None
 1.39A 2l8mA-3fbgA:
undetectable		 2l8mA-3fbgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 7 ILE A 315
ARG A  50
TYR A 316
GLU A 323
 None
 1.16A 2qebA-3fbgA:
undetectable		 2qebA-3fbgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 7 ILE A 315
ARG A  50
TYR A 316
GLU A 323
 None
 1.11A 2qebB-3fbgA:
undetectable		 2qebB-3fbgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 9 GLY A 193
ALA A 194
ASP A 195
ILE A 177
ILE A 168
 None
 1.02A 3ogpB-3fbgA:
undetectable		 3ogpB-3fbgA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 5 GLY A 157
THR A 166
ILE A 177
VAL A 176
 None
 0.89A 3wriA-3fbgA:
undetectable		 3wriA-3fbgA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 5 GLY A 157
THR A 166
ILE A 177
VAL A 176
 None
 0.89A 3wriB-3fbgA:
undetectable		 3wriB-3fbgA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 8 THR A 166
GLY A 159
GLY A 160
VAL A 161
 None
 0.78A 4qvvK-3fbgA:
undetectable
4qvvL-3fbgA:
undetectable		 4qvvK-3fbgA:
21.07
4qvvL-3fbgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 8 THR A 166
GLY A 159
GLY A 160
VAL A 161
 None
 0.78A 4qvvY-3fbgA:
undetectable
4qvvZ-3fbgA:
undetectable		 4qvvY-3fbgA:
21.07
4qvvZ-3fbgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.45A 4w5qA-3fbgA:
2.0		 4w5qA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.47A 4w5rA-3fbgA:
2.1		 4w5rA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.47A 4w5tA-3fbgA:
undetectable		 4w5tA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		3 / 3 TYR A 286
ARG A 272
LYS A 282
 None
 1.48A 4wq5B-3fbgA:
undetectable		 4wq5B-3fbgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 11 GLY A  89
SER A  96
ALA A  98
ILE A  37
LEU A  34
 None
 1.19A 4xumB-3fbgA:
undetectable		 4xumB-3fbgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 LEU A 322
ASN A  43
PRO A  44
ARG A 182
 None
 1.24A 4yv5B-3fbgA:
undetectable		 4yv5B-3fbgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 LEU A 322
ASN A  43
PRO A  44
ARG A 182
 None
 1.22A 4yv5A-3fbgA:
undetectable		 4yv5A-3fbgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.48A 4z4cA-3fbgA:
undetectable		 4z4cA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.44A 4z4fA-3fbgA:
undetectable		 4z4fA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 5 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.46A 4z4gA-3fbgA:
undetectable		 4z4gA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 6 GLY A 173
GLU A 148
ARG A 144
ASN A 145
 None
 1.28A 4zbqA-3fbgA:
undetectable		 4zbqA-3fbgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 5 GLN A 101
ILE A 103
ILE A  33
TYR A  87
 None
 1.18A 5dnuA-3fbgA:
undetectable		 5dnuA-3fbgA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		4 / 5 GLN A 101
ILE A 103
ILE A  33
TYR A  87
 None
 1.17A 5dnvA-3fbgA:
4.9		 5dnvA-3fbgA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		3 / 3 GLY A 193
GLN A 300
LYS A 170
 None
 0.77A 5imsB-3fbgA:
3.4		 5imsB-3fbgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 12 ILE A 168
GLY A 127
ALA A 165
PHE A 220
ALA A 169
 None
 1.16A 5n0oB-3fbgA:
undetectable		 5n0oB-3fbgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3fbg PUTATIVE ARGINATE
LYASE
(Staphylococcus
haemolyticus) 		5 / 12 PHE A 220
ILE A 154
LEU A 152
GLY A 127
ALA A 130
 None
 1.02A 5zwrA-3fbgA:
undetectable		 5zwrA-3fbgA:
18.76