SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 10 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.32A 3fhjA-3fbkA:
undetectable		 3fhjA-3fbkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 10 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.35A 3fhjB-3fbkA:
undetectable		 3fhjB-3fbkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 10 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.33A 3fhjC-3fbkA:
undetectable		 3fhjC-3fbkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 10 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.30A 3fhjE-3fbkA:
undetectable		 3fhjE-3fbkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.31A 3fi0A-3fbkA:
undetectable		 3fi0A-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.33A 3fi0C-3fbkA:
undetectable		 3fi0C-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.43A 3fi0D-3fbkA:
undetectable		 3fi0D-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.43A 3fi0F-3fbkA:
undetectable		 3fi0F-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.31A 3fi0H-3fbkA:
undetectable		 3fi0H-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.43A 3fi0J-3fbkA:
undetectable		 3fi0J-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.36A 3fi0K-3fbkA:
undetectable		 3fi0K-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.28A 3fi0L-3fbkA:
undetectable		 3fi0L-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.31A 3fi0M-3fbkA:
undetectable		 3fi0M-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.30A 3fi0N-3fbkA:
undetectable		 3fi0N-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.28A 3fi0O-3fbkA:
undetectable		 3fi0O-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 9 GLY A  55
GLN A  36
ILE A  52
VAL A  70
VAL A 118
 None
 1.33A 3fi0R-3fbkA:
undetectable		 3fi0R-3fbkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		4 / 4 LEU A 155
GLY A 156
GLY A 160
THR A 162
 None
 0.80A 3si7A-3fbkA:
undetectable		 3si7A-3fbkA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 12 PHE A  97
LEU A 154
ILE A 131
ARG A 121
GLY A  35
 None
 1.10A 4dm8B-3fbkA:
undetectable		 4dm8B-3fbkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		4 / 6 PRO A  95
ILE A 131
VAL A 116
THR A  86
 None
 0.89A 4xe5A-3fbkA:
undetectable		 4xe5A-3fbkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 12 LEU A  50
VAL A 116
LEU A 141
PHE A 136
MET A 134
 None
 1.07A 4y0qA-3fbkA:
undetectable		 4y0qA-3fbkA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		4 / 4 GLU A  77
PRO A  76
ILE A  75
LEU A  74
 None
 0.87A 5m45A-3fbkA:
undetectable		 5m45A-3fbkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		4 / 4 GLU A  77
PRO A  76
ILE A  75
LEU A  74
 None
 0.85A 5m45D-3fbkA:
undetectable		 5m45D-3fbkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		4 / 4 GLU A  77
PRO A  76
ILE A  75
LEU A  74
 None
 0.85A 5m45G-3fbkA:
undetectable		 5m45G-3fbkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		4 / 4 GLU A  77
PRO A  76
ILE A  75
LEU A  74
 None
 0.86A 5m45J-3fbkA:
undetectable		 5m45J-3fbkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens) 		5 / 12 ILE A  52
VAL A 118
LEU A  50
MET A 134
LEU A 114
 None
 1.25A 6b54A-3fbkA:
undetectable		 6b54A-3fbkA:
21.43