SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 4 SER A 145
GLU A 150
SER A 109
ASP A 113
 None
 1.50A 1h1dA-3fbqA:
0.0		 1h1dA-3fbqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 6 THR A  57
SER A  28
ASP A  46
VAL A 174
 None
 1.30A 2hdnI-3fbqA:
undetectable
2hdnJ-3fbqA:
undetectable
2hdnL-3fbqA:
undetectable		 2hdnI-3fbqA:
10.00
2hdnJ-3fbqA:
22.34
2hdnL-3fbqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 4 SER A  85
GLY A  86
GLY A 216
GLY A 213
 None
 0.81A 3bogB-3fbqA:
undetectable
3bogD-3fbqA:
undetectable		 3bogB-3fbqA:
undetectable
3bogD-3fbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.07A 3eeyA-3fbqA:
undetectable		 3eeyA-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.10A 3eeyB-3fbqA:
undetectable		 3eeyB-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.10A 3eeyC-3fbqA:
undetectable		 3eeyC-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.05A 3eeyD-3fbqA:
undetectable		 3eeyD-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.01A 3eeyH-3fbqA:
undetectable		 3eeyH-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.03A 3eeyI-3fbqA:
undetectable		 3eeyI-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.11A 3eeyJ-3fbqA:
undetectable		 3eeyJ-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 7 ARG A 189
VAL A 184
TYR A 222
ILE A 224
 None
 0.95A 3hgxA-3fbqA:
undetectable		 3hgxA-3fbqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 9 LEU A  31
ASN A  32
GLY A   7
ILE A   9
THR A  29
 None
 1.23A 3spkA-3fbqA:
undetectable		 3spkA-3fbqA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 5 ASP A  14
GLU A  22
GLY A  19
TYR A  21
 None
 1.39A 3w9tD-3fbqA:
undetectable		 3w9tD-3fbqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 5 ASP A  14
GLU A  22
GLY A  19
TYR A  21
 None
 1.39A 3w9tE-3fbqA:
undetectable		 3w9tE-3fbqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 5 ASP A  14
GLU A  22
GLY A  19
TYR A  21
 None
 1.40A 3w9tG-3fbqA:
undetectable		 3w9tG-3fbqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 7 TYR A  24
THR A 103
LEU A  20
ASP A  50
 None
 0.82A 4cp4A-3fbqA:
undetectable		 4cp4A-3fbqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 4 SER A 145
GLU A 150
SER A 109
ASP A 113
 None
 1.47A 4xucA-3fbqA:
0.0		 4xucA-3fbqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		4 / 5 SER A 145
GLU A 150
SER A 109
ASP A 113
 None
 1.50A 5fhrA-3fbqA:
undetectable		 5fhrA-3fbqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 9 SER A 175
THR A 103
SER A  55
ILE A  48
THR A 105
 None
 1.15A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 9 THR A 103
SER A  55
ILE A  48
THR A 229
SER A 175
 None
 1.40A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 9 THR A 103
THR A  53
ILE A  48
THR A 229
SER A 175
 None
 1.36A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 9 THR A 229
SER A 175
THR A 103
SER A  55
THR A 105
 None
 1.31A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 GLU A 198
VAL A 197
HIS A 107
THR A 103
GLY A  86
 None
 1.07A 5xipC-3fbqA:
undetectable		 5xipC-3fbqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3fbq CONSERVED DOMAIN
PROTEIN
(Bacillus
anthracis) 		5 / 12 GLU A 198
VAL A 197
HIS A 107
THR A 103
GLY A  86
 None
 1.11A 5xiqD-3fbqA:
undetectable		 5xiqD-3fbqA:
19.92