SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN
(Clostridium
acetobutylicum) 		4 / 8 ILE A 172
ASN A 196
GLY A 194
LEU A 185
 None
 0.79A 1dzmA-3fbtA:
undetectable		 1dzmA-3fbtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN
(Clostridium
acetobutylicum) 		5 / 12 THR A 146
ILE A 150
LEU A 155
VAL A 157
ILE A 192
 None
 1.30A 3sp9A-3fbtA:
undetectable		 3sp9A-3fbtA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN
(Clostridium
acetobutylicum) 		4 / 8 SER A 111
HIS A 110
TYR A 308
ILE A 116
 None
 1.24A 4ms4A-3fbtA:
2.4		 4ms4A-3fbtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN
(Clostridium
acetobutylicum) 		4 / 4 VAL A 274
ILE A 242
ASN A 237
VAL A 230
 None
 1.25A 5ajqA-3fbtA:
undetectable		 5ajqA-3fbtA:
24.39