SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 6 TYR A  78
THR A 123
GLU A  85
GLU A 159
 None
 0.99A 2dttB-3fbuA:
undetectable
2dttC-3fbuA:
undetectable		 2dttB-3fbuA:
25.15
2dttC-3fbuA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 4 ARG A 141
GLY A 139
GLU A 168
SER A 131
 None
None
None
COA  A 169 (-3.2A)
 1.21A 2xctS-3fbuA:
undetectable
2xctU-3fbuA:
undetectable		 2xctS-3fbuA:
13.38
2xctU-3fbuA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 5 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 1.18A 3k9fA-3fbuA:
undetectable
3k9fB-3fbuA:
undetectable
3k9fC-3fbuA:
undetectable		 3k9fA-3fbuA:
15.85
3k9fB-3fbuA:
15.85
3k9fC-3fbuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 8 PHE A  90
VAL A  61
MET A   1
ILE A  10
 COA  A 169 (-4.6A)
None
None
None
 1.05A 4a97I-3fbuA:
undetectable		 4a97I-3fbuA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 5 ARG A 141
GLY A 139
GLU A 168
SER A 131
 None
None
None
COA  A 169 (-3.2A)
 1.20A 4z3oA-3fbuA:
undetectable
4z3oB-3fbuA:
undetectable		 4z3oA-3fbuA:
11.25
4z3oB-3fbuA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 7 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 0.83A 5btaA-3fbuA:
undetectable
5btaC-3fbuA:
undetectable
5btaD-3fbuA:
undetectable		 5btaA-3fbuA:
15.22
5btaC-3fbuA:
15.22
5btaD-3fbuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 6 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 0.85A 5btaA-3fbuA:
undetectable
5btaB-3fbuA:
undetectable
5btaC-3fbuA:
undetectable		 5btaA-3fbuA:
15.22
5btaB-3fbuA:
21.86
5btaC-3fbuA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 6 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 0.82A 5btcA-3fbuA:
undetectable
5btcC-3fbuA:
undetectable
5btcD-3fbuA:
undetectable		 5btcA-3fbuA:
15.22
5btcC-3fbuA:
15.22
5btcD-3fbuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 6 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 0.84A 5btcA-3fbuA:
undetectable
5btcB-3fbuA:
undetectable
5btcC-3fbuA:
undetectable		 5btcA-3fbuA:
15.22
5btcB-3fbuA:
21.86
5btcC-3fbuA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 7 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 0.87A 5btfA-3fbuA:
undetectable
5btfB-3fbuA:
undetectable
5btfC-3fbuA:
undetectable		 5btfA-3fbuA:
15.22
5btfB-3fbuA:
21.86
5btfC-3fbuA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 7 SER A 131
ARG A 141
GLY A 139
GLU A 168
 COA  A 169 (-3.2A)
None
None
None
 0.91A 5btfA-3fbuA:
undetectable
5btfC-3fbuA:
undetectable
5btfD-3fbuA:
undetectable		 5btfA-3fbuA:
15.22
5btfC-3fbuA:
15.22
5btfD-3fbuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		5 / 12 GLY A  71
PHE A  90
LEU A   8
GLY A  87
VAL A 134
 None
COA  A 169 (-4.6A)
None
None
COA  A 169 ( 4.8A)
 1.12A 5tuiB-3fbuA:
undetectable		 5tuiB-3fbuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3fbu ACETYLTRANSFERASE,
GNAT FAMILY
(Bacillus
anthracis) 		4 / 8 ILE A  64
ALA A 106
THR A 107
TYR A 110
 None
 0.83A 6cduD-3fbuA:
undetectable
6cduE-3fbuA:
undetectable		 6cduD-3fbuA:
17.99
6cduE-3fbuA:
17.99