SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 9 ILE A 226
VAL A 165
GLY A 168
ALA A 190
LEU A 199
 None
 1.07A 1e7bA-3fcaA:
undetectable		 1e7bA-3fcaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ARG A 223
SER A 141
TYR A 140
 None
 0.61A 1x70A-3fcaA:
undetectable		 1x70A-3fcaA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 ILE A 226
ARG A 223
PRO A 281
GLY A 166
 None
 1.17A 2pnjB-3fcaA:
2.4		 2pnjB-3fcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLN A 132
PHE A 133
PHE A 216
GLY A 110
 None
 1.31A 2qmzA-3fcaA:
undetectable
2qmzB-3fcaA:
undetectable		 2qmzA-3fcaA:
21.78
2qmzB-3fcaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLN A 132
PHE A 133
PHE A 216
GLY A 113
 None
 1.40A 2qmzA-3fcaA:
undetectable
2qmzB-3fcaA:
undetectable		 2qmzA-3fcaA:
21.78
2qmzB-3fcaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 LEU A   5
ARG A   4
ILE A   6
 None
 0.64A 2xn5B-3fcaA:
undetectable		 2xn5B-3fcaA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A 177
LEU A 178
GLY A 175
ILE A 171
THR A 146
 None
 1.14A 3bjwF-3fcaA:
undetectable		 3bjwF-3fcaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLY A 213
GLU A 192
GLY A 215
PRO A 193
 None
 1.07A 3onnA-3fcaA:
2.5		 3onnA-3fcaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  95
THR A 167
ILE A 220
LEU A 130
HIS A 142
 None
 1.27A 3sp9B-3fcaA:
undetectable		 3sp9B-3fcaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 THR A 145
GLY A 147
GLY A 173
HIS A 142
GLN A 153
 None
 1.23A 3tkaA-3fcaA:
2.2		 3tkaA-3fcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 ILE A 290
GLN A 210
ILE A 209
TYR A 238
 None
 1.08A 4a99D-3fcaA:
2.1		 4a99D-3fcaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 163
ASN A 259
GLU A 149
VAL A 174
HIS A 142
 None
 1.23A 4azsA-3fcaA:
3.3		 4azsA-3fcaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 8 GLY A  31
ASN A  29
MET A  64
ILE A  71
 None
 0.98A 4j4vC-3fcaA:
undetectable		 4j4vC-3fcaA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A 132
LEU A 130
LEU A  81
GLY A  65
ILE A  56
 None
 1.29A 4o5fA-3fcaA:
undetectable
4o5fB-3fcaA:
undetectable		 4o5fA-3fcaA:
25.00
4o5fB-3fcaA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  81
GLY A  65
ILE A  56
GLN A 132
LEU A 130
 None
 1.23A 5b8hA-3fcaA:
undetectable
5b8hB-3fcaA:
undetectable		 5b8hA-3fcaA:
21.86
5b8hB-3fcaA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A 132
LEU A 130
LEU A  81
GLY A  65
ILE A  56
 None
 1.23A 5b8hA-3fcaA:
undetectable
5b8hB-3fcaA:
undetectable		 5b8hA-3fcaA:
21.86
5b8hB-3fcaA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 VAL A 165
ILE A 171
VAL A 229
ALA A 190
 None
 0.75A 5ospA-3fcaA:
undetectable		 5ospA-3fcaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLU A  26
VAL A 279
LEU A 221
ALA A 163
GLY A 211
 None
 1.21A 5syeB-3fcaA:
undetectable		 5syeB-3fcaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 THR A 278
ALA A 263
LYS A 265
 HQA  A  22 ( 4.6A)
None
None
 0.64A 6fgcA-3fcaA:
undetectable		 6fgcA-3fcaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3fca CYSTEINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 THR A 278
ALA A 263
LYS A 265
 HQA  A  22 ( 4.6A)
None
None
 0.68A 6fgdA-3fcaA:
undetectable		 6fgdA-3fcaA:
21.81