SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 6 LEU A 130
LEU A  44
SER A  76
THR A  36
 None
 1.02A 1ictB-3fcmA:
undetectable		 1ictB-3fcmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		3 / 3 HIS A  43
HIS A 129
HIS A 127
 MN  A 201 (-3.4A)
MN  A 201 (-3.5A)
MN  A 201 (-3.6A)
 0.69A 1rkyA-3fcmA:
undetectable		 1rkyA-3fcmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 4 HIS A  43
HIS A 129
HIS A  75
HIS A 127
 MN  A 201 (-3.4A)
MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.6A)
 1.05A 2wkoA-3fcmA:
undetectable		 2wkoA-3fcmA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 4 HIS A 129
HIS A  43
HIS A 127
HIS A  75
 MN  A 201 (-3.5A)
MN  A 201 (-3.4A)
MN  A 201 (-3.6A)
MN  A 201 (-3.3A)
 1.00A 2wkoA-3fcmA:
undetectable		 2wkoA-3fcmA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 5 HIS A  43
HIS A 129
HIS A  75
HIS A 127
 MN  A 201 (-3.4A)
MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.6A)
 1.06A 2wkoF-3fcmA:
undetectable		 2wkoF-3fcmA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 6 LEU A 130
LEU A  44
SER A  76
THR A  36
 None
 0.89A 3cfqA-3fcmA:
undetectable		 3cfqA-3fcmA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 6 LEU A 130
LEU A  44
SER A  76
THR A  36
 None
 1.00A 4i89A-3fcmA:
undetectable		 4i89A-3fcmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 6 LEU A 130
LEU A  44
SER A  76
THR A  36
 None
 1.05A 5bojA-3fcmA:
undetectable		 5bojA-3fcmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		5 / 12 VAL A 154
GLY A  74
THR A  45
GLN A  82
LEU A 132
 None
 1.18A 5hg0A-3fcmA:
undetectable		 5hg0A-3fcmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 5 HIS A 129
HIS A  75
HIS A  43
HIS A 127
 MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.4A)
MN  A 201 (-3.6A)
 1.00A 5zrdB-3fcmA:
undetectable		 5zrdB-3fcmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 4 HIS A 129
HIS A  75
HIS A  43
HIS A 127
 MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.4A)
MN  A 201 (-3.6A)
 0.97A 5zrdC-3fcmA:
undetectable		 5zrdC-3fcmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 3fcm HYDROLASE, NUDIX
FAMILY
(Clostridium
perfringens) 		4 / 4 HIS A 129
HIS A  75
HIS A  43
HIS A 127
 MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.4A)
MN  A 201 (-3.6A)
 0.99A 5zrdD-3fcmA:
undetectable		 5zrdD-3fcmA:
17.49