SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fcp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 ILE A  37
ILE A 109
VAL A 125
LEU A 358
ILE A  49
 None
 0.94A 1df7A-3fcpA:
undetectable		 1df7A-3fcpA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 6 LEU A 287
THR A 103
ALA A 278
LEU A 273
 None
 1.26A 1etb2-3fcpA:
undetectable		 1etb2-3fcpA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 11 LEU A 287
LEU A 285
ALA A 132
LEU A 298
HIS A 315
 None
 1.44A 1kt7A-3fcpA:
undetectable		 1kt7A-3fcpA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 9 THR A 371
VAL A  17
LEU A 362
ILE A 338
ASP A 337
 None
 1.21A 1nb9A-3fcpA:
undetectable		 1nb9A-3fcpA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 11 VAL A  17
TYR A 370
LEU A 362
ILE A 338
ASP A 337
 None
 1.29A 1t6zB-3fcpA:
undetectable		 1t6zB-3fcpA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 ALA A 294
TYR A 271
VAL A 253
GLY A 295
ILE A 296
 None
 1.37A 2dcfA-3fcpA:
undetectable		 2dcfA-3fcpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 LEU A 314
GLY A 309
ASP A 115
VAL A 125
GLY A 280
 None
 0.96A 2ieoA-3fcpA:
undetectable		 2ieoA-3fcpA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 5 LEU A  40
GLY A  50
ILE A  72
ILE A  10
 None
 0.74A 2q9rA-3fcpA:
undetectable		 2q9rA-3fcpA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 ALA A 294
TYR A 271
VAL A 253
GLY A 295
ILE A 296
 None
 1.30A 3a65A-3fcpA:
undetectable		 3a65A-3fcpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		3 / 3 LEU A 320
PRO A 321
LEU A 298
 None
 0.45A 3hcrA-3fcpA:
2.8		 3hcrA-3fcpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 6 VAL A 308
VAL A 125
ILE A 275
ARG A  39
 None
 1.15A 3mssC-3fcpA:
undetectable		 3mssC-3fcpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 LEU A 367
ARG A  39
GLY A 309
THR A 310
LEU A 362
 None
 1.21A 3okxB-3fcpA:
undetectable		 3okxB-3fcpA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 ILE A 275
GLY A 309
THR A 310
GLU A  51
THR A  53
 None
 1.19A 3r75A-3fcpA:
undetectable		 3r75A-3fcpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 ILE A 275
GLY A 309
THR A 310
GLU A  51
THR A  53
 None
 1.20A 3r75B-3fcpA:
undetectable		 3r75B-3fcpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 11 ILE A 275
GLY A 309
THR A 310
GLU A  51
THR A  53
 None
 1.17A 3r76A-3fcpA:
undetectable		 3r76A-3fcpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 11 ILE A 275
GLY A 309
THR A 310
GLU A  51
THR A  53
 None
 1.16A 3r76B-3fcpA:
undetectable		 3r76B-3fcpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 GLN A 241
GLY A 266
LEU A 248
GLY A 269
ALA A 252
 None
 1.00A 3sufA-3fcpA:
undetectable		 3sufA-3fcpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 5 VAL A 253
LEU A 287
LEU A 273
ILE A 296
 None
 0.96A 4a9jA-3fcpA:
undetectable		 4a9jA-3fcpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 LEU A  35
ASP A 115
ALA A 112
ALA A 108
VAL A  38
 None
 1.15A 4hfpD-3fcpA:
undetectable		 4hfpD-3fcpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 7 GLU A 327
ASP A 199
ASN A 201
ILE A  55
 None
MG  A 382 ( 4.3A)
MG  A 382 (-3.1A)
None
 1.11A 4ii8A-3fcpA:
undetectable		 4ii8A-3fcpA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 8 ILE A  46
GLY A 357
VAL A 339
SER A 340
 None
 0.84A 4r20A-3fcpA:
undetectable		 4r20A-3fcpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 7 THR A  53
GLU A  51
GLY A 330
GLY A 306
 None
 0.69A 4rdxA-3fcpA:
undetectable		 4rdxA-3fcpA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 SER A 126
LEU A 343
THR A 307
THR A 310
ALA A 312
 None
 1.36A 5dsgB-3fcpA:
undetectable		 5dsgB-3fcpA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		4 / 4 GLU A 225
PRO A 227
ILE A 224
LEU A 248
 None
 1.33A 5m45D-3fcpA:
1.0		 5m45D-3fcpA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 GLY A 279
SER A 107
LYS A 106
ASN A 282
GLU A 110
 None
 1.30A 5nwvA-3fcpA:
undetectable		 5nwvA-3fcpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 12 ALA A 254
LEU A 287
VAL A 284
LEU A 262
ASP A 250
 None
None
None
None
MG  A 382 (-3.2A)
 1.13A 5w7pA-3fcpA:
undetectable		 5w7pA-3fcpA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME
(Klebsiella
pneumoniae) 		5 / 10 ARG A 197
VAL A 198
LEU A 169
LEU A 176
GLY A 212
 None
 1.07A 6eu9B-3fcpA:
undetectable		 6eu9B-3fcpA:
12.68