SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ASN A 126
HIS A 322
ALA A 122
GLY A 299
 None
 1.13A 1c8lA-3fcrA:
undetectable		 1c8lA-3fcrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ASN A 126
HIS A 322
GLY A 299
TYR A 114
 None
 1.12A 1c8lA-3fcrA:
undetectable		 1c8lA-3fcrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A 113
LEU A 103
GLY A 299
PHE A 265
PHE A 115
 None
 1.40A 1fdsA-3fcrA:
2.9		 1fdsA-3fcrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 GLN A  68
GLU A  69
PHE A 434
ALA A  38
 None
 1.23A 1linA-3fcrA:
undetectable		 1linA-3fcrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 11 SER A 408
LEU A  58
PRO A 423
THR A 163
TYR A 152
 None
None
None
None
PLP  A 458 (-4.5A)
 1.44A 1mxfC-3fcrA:
2.7		 1mxfC-3fcrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 11 SER A 408
LEU A  58
PRO A 423
THR A 163
TYR A 152
 None
None
None
None
PLP  A 458 (-4.5A)
 1.42A 1mxfD-3fcrA:
2.8		 1mxfD-3fcrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 ALA A  94
VAL A 337
ALA A 334
HIS A 329
 None
 1.16A 1q23A-3fcrA:
undetectable		 1q23A-3fcrA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 5 ALA A 221
TYR A 133
ILE A 130
ASP A 282
 None
 1.22A 1upfA-3fcrA:
3.2		 1upfA-3fcrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 ALA A 221
TYR A 133
ILE A 130
ILE A 283
 None
 0.93A 1upfB-3fcrA:
3.3		 1upfB-3fcrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 343
GLY A 289
GLY A 264
LEU A 268
GLY A 273
 None
LLP  A 288 ( 2.4A)
None
None
None
 1.25A 1y4lA-3fcrA:
undetectable		 1y4lA-3fcrA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 GLY A 380
HIS A 276
TYR A 277
PRO A 237
 None
 1.20A 2armA-3fcrA:
undetectable		 2armA-3fcrA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ILE A 417
MET A 363
THR A 362
LEU A 359
 None
 0.98A 2einN-3fcrA:
undetectable
2einW-3fcrA:
undetectable		 2einN-3fcrA:
22.22
2einW-3fcrA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 381
PRO A 432
LEU A 436
ARG A 438
 None
 1.40A 2hrcA-3fcrA:
undetectable		 2hrcA-3fcrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 VAL A 257
ILE A 286
LEU A 103
ALA A 122
SER A 300
 None
 1.35A 2iyfB-3fcrA:
2.1		 2iyfB-3fcrA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ASN A 126
HIS A 322
GLY A 299
TYR A 114
 None
 1.14A 3dd1A-3fcrA:
undetectable		 3dd1A-3fcrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ASN A 126
HIS A 322
GLY A 299
TYR A 114
 None
 1.14A 3dd1B-3fcrA:
undetectable		 3dd1B-3fcrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ASN A 126
HIS A 322
GLY A 299
TYR A 114
 None
 1.15A 3ddwA-3fcrA:
undetectable		 3ddwA-3fcrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		6 / 12 LEU A 367
LEU A 411
ALA A 451
ILE A 234
CYH A 383
LEU A 359
 None
 1.43A 3h0aA-3fcrA:
undetectable		 3h0aA-3fcrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 381
PRO A 432
LEU A 436
ARG A 438
 None
 1.24A 3hcoB-3fcrA:
undetectable		 3hcoB-3fcrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 8 PRO A 405
SER A 408
PRO A 423
MET A 422
 None
 1.14A 3hcrA-3fcrA:
2.1		 3hcrA-3fcrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 119
SER A 120
LEU A 117
ILE A 102
LEU A 290
 PLP  A 458 (-3.1A)
PLP  A 458 (-2.7A)
None
None
None
 0.99A 3mb5A-3fcrA:
undetectable		 3mb5A-3fcrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 353
ALA A 441
LEU A 382
THR A 362
LEU A 359
 None
 1.11A 3p2kB-3fcrA:
undetectable		 3p2kB-3fcrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 356
GLY A 380
LEU A 268
ALA A 441
PHE A 434
 None
 1.01A 3vywB-3fcrA:
undetectable		 3vywB-3fcrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 GLY A 356
GLY A 380
LEU A 268
ALA A 441
PHE A 434
 None
 1.04A 3vywD-3fcrA:
undetectable		 3vywD-3fcrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 8 GLN A 195
GLU A 191
ILE A 245
VAL A 248
 None
 0.97A 4dx7B-3fcrA:
undetectable		 4dx7B-3fcrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 SER A  86
TYR A  87
PRO A 330
 None
 0.83A 4kahA-3fcrA:
undetectable		 4kahA-3fcrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 SER A  86
TYR A  87
PRO A 330
 None
 0.83A 4kahB-3fcrA:
undetectable		 4kahB-3fcrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 SER A  86
TYR A  87
PRO A 330
 None
 0.83A 4kanA-3fcrA:
undetectable		 4kanA-3fcrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 SER A  86
TYR A  87
PRO A 330
 None
 0.84A 4kbeA-3fcrA:
undetectable		 4kbeA-3fcrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 SER A  86
TYR A  87
PRO A 330
 None
 0.82A 4kbeB-3fcrA:
undetectable		 4kbeB-3fcrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 11 VAL A 257
ILE A 286
LEU A 103
ALA A 122
SER A 300
 None
 1.34A 4m83A-3fcrA:
undetectable		 4m83A-3fcrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 GLU A 440
ASP A  53
ASN A  62
ARG A 267
 None
 1.32A 4ntxA-3fcrA:
undetectable
4ntxC-3fcrA:
undetectable		 4ntxA-3fcrA:
21.32
4ntxC-3fcrA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 GLU A 226
ARG A 377
GLY A 233
GLY A 230
 LLP  A 288 (-4.0A)
None
None
None
 0.83A 4rdxA-3fcrA:
undetectable		 4rdxA-3fcrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 ALA A 258
LEU A 256
LEU A 255
ILE A 284
 None
 0.87A 4ubsA-3fcrA:
undetectable		 4ubsA-3fcrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 6 LEU A 456
PHE A 397
ILE A 427
PHE A 387
 None
 1.05A 4y4dA-3fcrA:
undetectable		 4y4dA-3fcrA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 PRO A 107
PHE A 272
PHE A 265
ILE A 284
VAL A 113
 None
 1.15A 4yfbC-3fcrA:
undetectable		 4yfbC-3fcrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 PRO A 107
PHE A 272
PHE A 265
ILE A 284
VAL A 113
 None
 1.15A 4yfbF-3fcrA:
undetectable		 4yfbF-3fcrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 PRO A 107
PHE A 272
PHE A 265
ILE A 284
VAL A 113
 None
 1.16A 4yfbI-3fcrA:
undetectable		 4yfbI-3fcrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 PRO A 107
PHE A 272
PHE A 265
ILE A 284
VAL A 113
 None
 1.14A 4yfbL-3fcrA:
undetectable		 4yfbL-3fcrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A  46
ASN A  32
ASP A  13
 EDO  A 459 (-4.5A)
None
None
 0.86A 5gwxA-3fcrA:
undetectable		 5gwxA-3fcrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 348
LEU A 359
MET A 363
ILE A 234
ALA A  56
 None
 1.37A 5ienA-3fcrA:
undetectable		 5ienA-3fcrA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.91A 5m45A-3fcrA:
undetectable		 5m45A-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.84A 5m45D-3fcrA:
undetectable		 5m45D-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.89A 5m45G-3fcrA:
undetectable		 5m45G-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.85A 5m45J-3fcrA:
undetectable		 5m45J-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 ARG A 189
TYR A 186
GLU A 386
LEU A 165
 None
 1.19A 5umwB-3fcrA:
undetectable
5umwE-3fcrA:
undetectable		 5umwB-3fcrA:
9.98
5umwE-3fcrA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 5 PRO A 319
GLY A 318
THR A 314
ASN A 317
 None
 1.15A 5x23A-3fcrA:
undetectable		 5x23A-3fcrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 ILE A 417
MET A 363
THR A 362
LEU A 359
 None
 0.91A 5xdqN-3fcrA:
undetectable
5xdqW-3fcrA:
undetectable		 5xdqN-3fcrA:
22.22
5xdqW-3fcrA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 10 LEU A 348
LEU A 359
ASN A  62
PHE A 430
ALA A  56
 None
 1.17A 5y7pB-3fcrA:
undetectable		 5y7pB-3fcrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 10 LEU A 348
LEU A 359
ASN A  62
PHE A 430
ALA A  56
 None
 1.15A 5y7pH-3fcrA:
undetectable		 5y7pH-3fcrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 11 ALA A 352
VAL A 262
THR A 263
ILE A 234
ALA A  56
 None
LLP  A 288 (-4.4A)
None
None
None
 1.10A 6h1lB-3fcrA:
undetectable		 6h1lB-3fcrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 VAL A 337
ILE A 102
GLY A 323
ALA A 328
 None
 0.87A 6hd6B-3fcrA:
undetectable		 6hd6B-3fcrA:
13.21