SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 6 GLN A 255
ASP A 221
VAL A 251
HIS A 272
 None
 1.36A 1ekjG-3fcxA:
undetectable
1ekjH-3fcxA:
undetectable		 1ekjG-3fcxA:
23.34
1ekjH-3fcxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 5 SER A  52
ALA A  80
ASP A  82
GLU A  58
 None
 1.02A 1lqtA-3fcxA:
undetectable
1lqtB-3fcxA:
undetectable		 1lqtA-3fcxA:
21.12
1lqtB-3fcxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 5 SER A  52
ALA A  80
ASP A  82
GLU A  58
 None
 1.01A 1lquA-3fcxA:
undetectable
1lquB-3fcxA:
undetectable		 1lquA-3fcxA:
21.12
1lquB-3fcxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 8 GLY A 147
SER A 170
TYR A  67
HIS A 276
 None
 0.86A 1maaD-3fcxA:
16.5		 1maaD-3fcxA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 4 LEU A 207
SER A 210
TYR A 211
LEU A 160
 None
 1.10A 1xz1A-3fcxA:
undetectable		 1xz1A-3fcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 4 LEU A 207
SER A 210
TYR A 211
LEU A 160
 None
 1.10A 1xz3A-3fcxA:
undetectable		 1xz3A-3fcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 7 ARG A 142
LEU A 280
PRO A  81
VAL A  78
 None
 1.18A 2hrcA-3fcxA:
2.0		 2hrcA-3fcxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		3 / 3 PRO A  81
PHE A  19
LYS A  31
 None
 1.19A 3bjwG-3fcxA:
undetectable		 3bjwG-3fcxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A  76
LEU A  48
VAL A  78
SER A 170
HIS A  68
 None
 1.22A 3m7rA-3fcxA:
undetectable		 3m7rA-3fcxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 6 LEU A 207
SER A 210
TYR A 211
LEU A 160
 None
 1.05A 3ravA-3fcxA:
undetectable		 3ravA-3fcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		5 / 12 SER A  70
ILE A 265
VAL A  78
LEU A  48
LEU A 219
 None
 1.11A 3w67D-3fcxA:
3.1		 3w67D-3fcxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 8 PHE A 264
TYR A 262
GLY A 152
ILE A 175
 None
 0.92A 4qoiA-3fcxA:
undetectable
4qoiB-3fcxA:
2.8		 4qoiA-3fcxA:
23.53
4qoiB-3fcxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		4 / 5 ILE A 157
CYH A 158
LEU A  51
HIS A 153
 MG  A 283 ( 4.9A)
None
None
MG  A 283 (-3.7A)
 1.48A 5hrqC-3fcxA:
undetectable
5hrqD-3fcxA:
undetectable
5hrqL-3fcxA:
undetectable		 5hrqC-3fcxA:
5.34
5hrqD-3fcxA:
17.24
5hrqL-3fcxA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		5 / 11 ASN A 162
VAL A 107
THR A 125
TYR A 191
LEU A 192
 None
 1.44A 5jh7D-3fcxA:
2.8		 5jh7D-3fcxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens) 		5 / 12 ILE A 157
PRO A 178
GLY A 152
HIS A 148
GLY A 154
 MG  A 283 ( 4.9A)
MG  A 283 (-4.2A)
None
None
None
 1.07A 5l6eA-3fcxA:
undetectable		 5l6eA-3fcxA:
22.64