SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 6 PRO A  40
PHE A  61
GLN A 160
VAL A 165
 None
 1.29A 1l2iB-3fcyA:
undetectable		 1l2iB-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 9 ILE A  69
SER A 123
LEU A 150
ILE A 154
ASP A 157
 None
 1.19A 1nb9A-3fcyA:
undetectable		 1nb9A-3fcyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 6 PHE A 151
PHE A 155
GLY A 184
GLY A 185
 None
 0.82A 2qr2A-3fcyA:
2.4
2qr2B-3fcyA:
3.1		 2qr2A-3fcyA:
20.11
2qr2B-3fcyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 5 GLY A 184
GLY A 185
PHE A 151
PHE A 155
 None
 0.90A 2qr2A-3fcyA:
2.3
2qr2B-3fcyA:
3.1		 2qr2A-3fcyA:
20.11
2qr2B-3fcyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 8 PHE A 151
PHE A 155
GLY A 184
GLY A 185
 None
 0.88A 2qx4A-3fcyA:
2.3
2qx4B-3fcyA:
3.4		 2qx4A-3fcyA:
20.11
2qx4B-3fcyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 11 ILE A  86
ALA A 159
ILE A  42
LEU A  59
VAL A 165
 None
 1.15A 3n0hA-3fcyA:
undetectable		 3n0hA-3fcyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 12 GLY A 118
ASP A 125
ASP A 144
ASP A 157
ILE A  69
 None
 1.11A 3prsA-3fcyA:
undetectable		 3prsA-3fcyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 12 PHE A 207
HIS A 301
ASP A 272
GLY A  90
SER A 182
 None
 1.02A 3sueD-3fcyA:
undetectable		 3sueD-3fcyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 12 PHE A 207
HIS A 301
ASP A 272
GLY A  90
SER A 182
 None
 0.99A 3sufB-3fcyA:
undetectable		 3sufB-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 11 PHE A 207
HIS A 301
ASP A 272
GLY A  90
SER A 182
 None
 1.05A 3sufC-3fcyA:
undetectable		 3sufC-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		3 / 3 PHE A 314
LYS A 290
SER A 289
 None
 1.26A 3tyeB-3fcyA:
undetectable		 3tyeB-3fcyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 8 ASP A  23
CYH A  20
ASP A  25
GLU A  26
 None
 1.17A 4feuF-3fcyA:
undetectable		 4feuF-3fcyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 5 THR A 246
PRO A  19
PHE A 231
ASN A  18
 None
 1.20A 4mf6A-3fcyA:
undetectable		 4mf6A-3fcyA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 7 GLN A 119
HIS A  89
VAL A 116
PHE A 151
LEU A 187
 None
 1.40A 5m78A-3fcyA:
undetectable		 5m78A-3fcyA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		5 / 12 PHE A 207
ALA A 223
ILE A 139
SER A  92
LEU A 248
 None
 1.19A 5uanB-3fcyA:
undetectable		 5uanB-3fcyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		3 / 3 TYR A  60
ASP A 115
ASP A  58
 None
 0.68A 5x6yA-3fcyA:
undetectable		 5x6yA-3fcyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 7 ILE A  86
LEU A  85
ILE A 260
ALA A 311
 None
 0.80A 6b5vA-3fcyA:
undetectable
6b5vC-3fcyA:
undetectable		 6b5vA-3fcyA:
13.12
6b5vC-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 7 ALA A 311
ILE A  86
LEU A  85
ILE A 260
 None
 0.80A 6b5vA-3fcyA:
undetectable
6b5vB-3fcyA:
undetectable		 6b5vA-3fcyA:
13.12
6b5vB-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 7 ILE A  86
LEU A  85
ILE A 260
ALA A 311
 None
 0.80A 6b5vC-3fcyA:
undetectable
6b5vD-3fcyA:
undetectable		 6b5vC-3fcyA:
13.12
6b5vD-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 7 ALA A 311
ILE A  86
LEU A  85
ILE A 260
 None
 0.81A 6b5vB-3fcyA:
undetectable
6b5vD-3fcyA:
undetectable		 6b5vB-3fcyA:
13.12
6b5vD-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 6 VAL A 268
LEU A   8
LEU A  11
ARG A  12
 None
 1.02A 6e43B-3fcyA:
undetectable		 6e43B-3fcyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 6 VAL A 268
LEU A   8
LEU A  11
ARG A  12
 None
 0.98A 6e43D-3fcyA:
undetectable		 6e43D-3fcyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		3 / 3 PHE A  24
ARG A 259
ALA A  31
 None
 0.76A 6ecfB-3fcyA:
11.1		 6ecfB-3fcyA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3fcy XYLAN ESTERASE 1
(Thermoanaerobact
erium
saccharolyticum) 		4 / 7 ASP A 115
GLN A 122
SER A  95
GLY A  96
 None
 0.70A 6ekzA-3fcyA:
undetectable		 6ekzA-3fcyA:
12.76