SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.40A 1hrkB-3fd2A:
undetectable		 1hrkB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 11 GLY A  17
GLY A 220
ILE A 264
TYR A 260
PRO A 259
 None
 1.18A 1p91A-3fd2A:
undetectable		 1p91A-3fd2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 11 GLY A 220
GLY A  17
ILE A  61
TYR A  57
PRO A  56
 None
 1.19A 1p91A-3fd2A:
undetectable		 1p91A-3fd2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.40A 2hrcA-3fd2A:
undetectable		 2hrcA-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.40A 2hrcB-3fd2A:
undetectable		 2hrcB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.39A 2pnjB-3fd2A:
undetectable		 2pnjB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 8 ASN A 109
LYS A 106
LYS A 105
PHE A  48
 None
 1.08A 3bjwD-3fd2A:
undetectable		 3bjwD-3fd2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 8 ASN A 312
LYS A 309
LYS A 308
PHE A 251
 None
 1.06A 3bjwD-3fd2A:
undetectable		 3bjwD-3fd2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.34A 3hcoB-3fd2A:
undetectable		 3hcoB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 9 ALA A 108
LEU A 101
ILE A  15
LEU A   7
ILE A  93
 None
 1.15A 3jw3B-3fd2A:
undetectable		 3jw3B-3fd2A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 9 ALA A 311
LEU A 304
ILE A 218
LEU A 210
ILE A 296
 None
 1.21A 3jw3B-3fd2A:
undetectable		 3jw3B-3fd2A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 5 LYS A 104
ILE A  46
PHE A  48
ASP A  22
 None
None
None
CA  A 375 (-2.3A)
 1.08A 3kp6A-3fd2A:
undetectable
3kp6B-3fd2A:
undetectable		 3kp6A-3fd2A:
18.92
3kp6B-3fd2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 5 LYS A 307
ILE A 249
PHE A 251
ASP A 225
 None
None
None
CA  A 374 (-2.4A)
 1.11A 3kp6A-3fd2A:
undetectable
3kp6B-3fd2A:
undetectable		 3kp6A-3fd2A:
18.92
3kp6B-3fd2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 6 GLN A  41
ILE A  30
PRO A  31
PHE A 128
 None
 1.04A 4fgkA-3fd2A:
undetectable		 4fgkA-3fd2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 6 GLN A 244
ILE A 233
PRO A 234
PHE A 331
 None
 1.15A 4fgkA-3fd2A:
undetectable		 4fgkA-3fd2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 7 ILE A  25
PHE A  48
LEU A  97
ILE A  93
 None
 0.87A 4rmjA-3fd2A:
undetectable		 4rmjA-3fd2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 7 ILE A 228
PHE A 251
LEU A 300
ILE A 296
 None
 0.87A 4rmjA-3fd2A:
undetectable		 4rmjA-3fd2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		3 / 3 PHE A  55
ASP A  60
LEU A 344
 None
 0.78A 5uhbC-3fd2A:
2.2		 5uhbC-3fd2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		3 / 3 PHE A 258
ASP A 263
LEU A 141
 None
 0.75A 5uhbC-3fd2A:
2.2		 5uhbC-3fd2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		3 / 3 PHE A 258
ASP A 263
LEU A 141
 None
 0.76A 5uhcC-3fd2A:
1.7		 5uhcC-3fd2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 12 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.05A 5x66A-3fd2A:
undetectable
5x66B-3fd2A:
undetectable		 5x66A-3fd2A:
21.67
5x66B-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 12 ILE A 264
GLY A 226
PHE A 221
TYR A 229
ALA A 248
 None
 1.03A 5x66A-3fd2A:
undetectable
5x66B-3fd2A:
undetectable		 5x66A-3fd2A:
21.67
5x66B-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 9 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.03A 5x66C-3fd2A:
undetectable		 5x66C-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 9 ILE A 264
GLY A 226
PHE A 221
TYR A 229
ALA A 248
 None
 1.02A 5x66C-3fd2A:
undetectable		 5x66C-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 10 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.06A 5x66D-3fd2A:
undetectable		 5x66D-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 10 ILE A 264
GLY A 226
PHE A 221
TYR A 229
ALA A 248
 None
 1.04A 5x66D-3fd2A:
undetectable		 5x66D-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 12 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.05A 5x66F-3fd2A:
undetectable		 5x66F-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 12 ILE A 264
GLY A 226
PHE A 221
TYR A 229
ALA A 248
 None
 1.03A 5x66F-3fd2A:
undetectable		 5x66F-3fd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		5 / 12 TYR A  82
LEU A  58
ILE A 306
LEU A   7
LEU A  97
 None
 1.50A 5ycpA-3fd2A:
undetectable		 5ycpA-3fd2A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI
(Monomastix
sp.
OKE-1) 		4 / 5 LEU A 268
LEU A 222
THR A 286
ARG A 254
 None
 1.11A 6ew0F-3fd2A:
undetectable		 6ew0F-3fd2A:
12.33