SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 10 ASN A 261
LEU A 260
GLN A 223
SER A 244
PHE A 248
 None
None
None
None
CA  A   1 (-3.7A)
 1.43A 2c2bA-3fd3A:
0.2
2c2bB-3fd3A:
0.0		 2c2bA-3fd3A:
18.55
2c2bB-3fd3A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_D_SAMD500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 9 ASN A 261
LEU A 260
GLN A 223
SER A 244
PHE A 248
 None
None
None
None
CA  A   1 (-3.7A)
 1.41A 2c2bC-3fd3A:
0.0
2c2bD-3fd3A:
0.0		 2c2bC-3fd3A:
18.55
2c2bD-3fd3A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 11 SER A 244
PHE A 248
ASN A 261
LEU A 260
GLN A 223
 None
CA  A   1 (-3.7A)
None
None
None
 1.42A 2c2bE-3fd3A:
undetectable
2c2bF-3fd3A:
undetectable		 2c2bE-3fd3A:
18.55
2c2bF-3fd3A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 10 ASN A 261
LEU A 260
GLN A 223
SER A 244
PHE A 248
 None
None
None
None
CA  A   1 (-3.7A)
 1.42A 2c2bE-3fd3A:
0.0
2c2bF-3fd3A:
0.3		 2c2bE-3fd3A:
18.55
2c2bF-3fd3A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 12 LEU A 303
ALA A 146
ILE A 145
LEU A 181
PHE A 128
 None
PG4  A 321 ( 3.8A)
None
None
None
 0.97A 2h42C-3fd3A:
undetectable		 2h42C-3fd3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		4 / 5 TYR A 237
GLN A 223
ILE A 286
LEU A 222
 None
None
None
EDO  A 322 (-4.4A)
 1.06A 3ls4L-3fd3A:
undetectable		 3ls4L-3fd3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		4 / 8 THR A 167
VAL A 154
VAL A 178
ASP A 170
 None
 1.16A 4l4eA-3fd3A:
undetectable		 4l4eA-3fd3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 11 ALA A 188
ASP A 193
GLY A 213
SER A 252
GLY A 255
 None
 1.12A 4xp4A-3fd3A:
undetectable		 4xp4A-3fd3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		4 / 7 LEU A 315
ILE A 145
THR A 119
MET A 307
 None
 1.15A 5ljcA-3fd3A:
undetectable		 5ljcA-3fd3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 9 LEU A 265
LEU A 184
ILE A 145
THR A 119
LEU A 129
 None
 1.41A 5ljdA-3fd3A:
undetectable		 5ljdA-3fd3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 10 LEU A 222
TYR A 186
LEU A 265
LEU A 124
ALA A 121
 EDO  A 322 (-4.4A)
None
None
None
None
 1.14A 5y7pB-3fd3A:
undetectable		 5y7pB-3fd3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 10 LEU A 222
TYR A 186
LEU A 265
LEU A 124
ALA A 121
 EDO  A 322 (-4.4A)
None
None
None
None
 1.21A 5y7pD-3fd3A:
undetectable		 5y7pD-3fd3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		5 / 10 LEU A 222
TYR A 186
LEU A 265
LEU A 124
ALA A 121
 EDO  A 322 (-4.4A)
None
None
None
None
 1.19A 5y7pH-3fd3A:
undetectable		 5y7pH-3fd3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		4 / 4 ASP A 122
ILE A 286
PRO A 287
LEU A 184
 EDO  A 322 (-2.9A)
None
None
None
 1.24A 6mkeB-3fd3A:
undetectable		 6mkeB-3fd3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN
(Agrobacterium
fabrum) 		4 / 4 ASP A 122
ILE A 286
PRO A 287
LEU A 184
 EDO  A 322 (-2.9A)
None
None
None
 1.23A 6mkeA-3fd3A:
undetectable		 6mkeA-3fd3A:
12.02