SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fdb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 5 PHE A   3
LEU A 282
VAL A 360
ASP A  33
 None
 1.39A 1dz6A-3fdbA:
undetectable		 1dz6A-3fdbA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 12 THR A 216
GLU A 189
GLY A 205
TYR A  70
ALA A 203
 None
 1.28A 1httC-3fdbA:
undetectable		 1httC-3fdbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 4 GLY A 346
ASP A 338
GLY A 322
THR A 318
 None
EDO  A 390 ( 4.5A)
EDO  A 388 (-4.2A)
EDO  A 388 (-4.6A)
 0.91A 1hxbB-3fdbA:
undetectable		 1hxbB-3fdbA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 171
LEU A 174
CYH A 175
LEU A 177
ALA A 178
 None
 0.69A 1s9pC-3fdbA:
undetectable		 1s9pC-3fdbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 8 PHE A 315
GLU A 321
GLY A 322
THR A 376
 None
None
EDO  A 388 (-4.2A)
None
 1.06A 1ykiA-3fdbA:
undetectable
1ykiB-3fdbA:
undetectable		 1ykiA-3fdbA:
22.34
1ykiB-3fdbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 8 THR A 376
PHE A 315
GLU A 321
GLY A 322
 None
None
None
EDO  A 388 (-4.2A)
 1.07A 1ykiA-3fdbA:
undetectable
1ykiB-3fdbA:
undetectable		 1ykiA-3fdbA:
22.34
1ykiB-3fdbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 8 PHE A 315
GLU A 321
GLY A 322
THR A 376
 None
None
EDO  A 388 (-4.2A)
None
 1.08A 1ykiC-3fdbA:
undetectable
1ykiD-3fdbA:
undetectable		 1ykiC-3fdbA:
22.34
1ykiD-3fdbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 8 THR A 376
PHE A 315
GLU A 321
GLY A 322
 None
None
None
EDO  A 388 (-4.2A)
 1.03A 1ykiC-3fdbA:
undetectable
1ykiD-3fdbA:
undetectable		 1ykiC-3fdbA:
22.34
1ykiD-3fdbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 7 ILE A 293
PHE A 315
ILE A 320
PHE A 328
 None
None
EDO  A 388 (-4.7A)
None
 1.20A 2qb4A-3fdbA:
undetectable		 2qb4A-3fdbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 12 ILE A 313
LEU A 352
ILE A 302
PHE A 315
VAL A 372
 None
 1.15A 2ygnA-3fdbA:
undetectable		 2ygnA-3fdbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 5 ALA A 267
GLY A 260
CYH A 231
LYS A 230
 None
None
None
CL  A 381 ( 4.3A)
 1.45A 2ylgA-3fdbA:
undetectable		 2ylgA-3fdbA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 9 ASP A  88
PHE A 100
ILE A 215
LEU A 186
ASP A 188
 CL  A 381 ( 3.0A)
None
None
None
LLP  A 222 ( 2.7A)
 1.37A 3m0wG-3fdbA:
undetectable
3m0wH-3fdbA:
undetectable
3m0wI-3fdbA:
undetectable
3m0wJ-3fdbA:
undetectable		 3m0wG-3fdbA:
14.55
3m0wH-3fdbA:
14.55
3m0wI-3fdbA:
14.55
3m0wJ-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 10 LEU A 186
ASP A 188
PHE A 100
ILE A 215
ASP A  88
 None
LLP  A 222 ( 2.7A)
None
None
CL  A 381 ( 3.0A)
 1.42A 3m0wE-3fdbA:
undetectable
3m0wF-3fdbA:
0.0
3m0wG-3fdbA:
undetectable
3m0wH-3fdbA:
undetectable		 3m0wE-3fdbA:
14.55
3m0wF-3fdbA:
14.55
3m0wG-3fdbA:
14.55
3m0wH-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 10 LEU A 186
ASP A 188
PHE A 100
ILE A 215
ASP A  88
 None
LLP  A 222 ( 2.7A)
None
None
CL  A 381 ( 3.0A)
 1.43A 3m0wA-3fdbA:
0.2
3m0wB-3fdbA:
undetectable
3m0wI-3fdbA:
undetectable
3m0wJ-3fdbA:
undetectable		 3m0wA-3fdbA:
14.55
3m0wB-3fdbA:
14.55
3m0wI-3fdbA:
14.55
3m0wJ-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 8 TYR A  76
TYR A  70
HIS A 200
LEU A 171
 None
 1.44A 3uzzB-3fdbA:
undetectable		 3uzzB-3fdbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 6 ILE A 302
LEU A 290
ARG A 351
THR A 308
 None
None
CL  A 379 ( 3.1A)
None
 1.05A 3wg7A-3fdbA:
undetectable
3wg7J-3fdbA:
undetectable		 3wg7A-3fdbA:
20.93
3wg7J-3fdbA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 7 ILE A 235
HIS A 191
VAL A 279
PHE A  69
 None
LLP  A 222 ( 4.0A)
EDO  A 384 (-4.6A)
None
 1.03A 4a97H-3fdbA:
undetectable		 4a97H-3fdbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 10 ALA A 178
ILE A 153
VAL A 142
VAL A 187
VAL A 185
 None
 1.03A 4j5jB-3fdbA:
undetectable		 4j5jB-3fdbA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 6 ARG A 126
GLN A 125
ILE A  97
ASP A  98
 None
None
None
EDO  A 387 (-3.7A)
 1.19A 4w5qA-3fdbA:
undetectable		 4w5qA-3fdbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 6 ILE A 302
LEU A 290
ARG A 351
THR A 308
 None
None
CL  A 379 ( 3.1A)
None
 0.95A 5b1aN-3fdbA:
undetectable
5b1aW-3fdbA:
undetectable		 5b1aN-3fdbA:
20.93
5b1aW-3fdbA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 11 THR A 216
GLU A 189
GLY A 205
TYR A  70
ALA A 203
 None
 1.32A 5e3iB-3fdbA:
undetectable		 5e3iB-3fdbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 7 ILE A 320
GLY A 322
ASP A 338
PHE A 342
 EDO  A 388 (-4.7A)
EDO  A 388 (-4.2A)
EDO  A 390 ( 4.5A)
None
 0.87A 5hieB-3fdbA:
undetectable		 5hieB-3fdbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 8 ILE A 320
GLY A 322
ASP A 338
PHE A 342
 EDO  A 388 (-4.7A)
EDO  A 388 (-4.2A)
EDO  A 390 ( 4.5A)
None
 0.86A 5hieD-3fdbA:
undetectable		 5hieD-3fdbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 6 ARG A  73
ALA A 192
PRO A 193
PHE A  69
 None
 1.35A 5odqA-3fdbA:
undetectable		 5odqA-3fdbA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		3 / 3 ARG A 351
PHE A 288
LEU A 282
 CL  A 379 ( 3.1A)
None
None
 0.81A 5veuA-3fdbA:
undetectable		 5veuA-3fdbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 12 ILE A 293
VAL A 372
LEU A 352
THR A 318
LEU A  27
 None
None
None
EDO  A 388 (-4.6A)
None
 1.17A 6b54A-3fdbA:
undetectable		 6b54A-3fdbA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 120
ILE A 153
GLY A 128
VAL A 142
PRO A 110
 None
 1.06A 6iftA-3fdbA:
undetectable		 6iftA-3fdbA:
23.45