SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fdd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
 PLP  A 534 (-2.8A)
PLP  A 534 (-3.7A)
None
None
None
 0.97A 1c9hA-3fddA:
undetectable		 1c9hA-3fddA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
 PLP  A 534 (-2.8A)
PLP  A 534 (-3.7A)
None
None
None
 1.00A 1fapA-3fddA:
undetectable		 1fapA-3fddA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 SER A 356
ARG A 355
TYR A 354
LEU A 357
 None
 1.14A 1ibgL-3fddA:
undetectable		 1ibgL-3fddA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 GLY A 325
VAL A 327
ALA A 319
SER A 314
TYR A 180
 None
None
None
PLP  A 534 (-2.5A)
None
 1.39A 1kiaD-3fddA:
undetectable		 1kiaD-3fddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 GLY A 325
VAL A 327
ALA A 319
SER A 314
TYR A 180
 None
None
None
PLP  A 534 (-2.5A)
None
 1.38A 1nbhA-3fddA:
undetectable		 1nbhA-3fddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 GLY A 325
VAL A 327
ALA A 319
SER A 314
TYR A 180
 None
None
None
PLP  A 534 (-2.5A)
None
 1.38A 1nbhD-3fddA:
undetectable		 1nbhD-3fddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.87A 1v54N-3fddA:
undetectable
1v54W-3fddA:
undetectable		 1v54N-3fddA:
21.01
1v54W-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.88A 1v55A-3fddA:
undetectable
1v55J-3fddA:
undetectable		 1v55A-3fddA:
21.01
1v55J-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.87A 1v55N-3fddA:
undetectable
1v55W-3fddA:
undetectable		 1v55N-3fddA:
21.01
1v55W-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 LEU A 398
TYR A 109
ILE A 147
ILE A 143
 None
 0.85A 2bu8A-3fddA:
undetectable		 2bu8A-3fddA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.82A 2dyrN-3fddA:
undetectable
2dyrW-3fddA:
undetectable		 2dyrN-3fddA:
21.01
2dyrW-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.84A 2einA-3fddA:
undetectable
2einJ-3fddA:
undetectable		 2einA-3fddA:
21.01
2einJ-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 GLY A 174
THR A 175
ALA A 176
ALA A 177
 PLP  A 534 (-3.4A)
PLP  A 534 (-3.6A)
None
None
 0.56A 2ej3A-3fddA:
undetectable		 2ej3A-3fddA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 325
GLY A 174
THR A 175
ALA A 176
ALA A 177
 None
PLP  A 534 (-3.4A)
PLP  A 534 (-3.6A)
None
None
 0.77A 2ej3B-3fddA:
undetectable		 2ej3B-3fddA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 6 TYR A 441
TYR A 289
GLY A  38
ASN A 502
 None
PLP  A 534 (-4.6A)
None
None
 1.07A 2g72A-3fddA:
undetectable		 2g72A-3fddA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HCJ_B_TACB888_1
(PROTEIN CHAIN
ELONGATION FACTOR
EF-TU)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 4 THR A 285
SER A 298
ASP A 287
PRO A 254
 None
 1.50A 2hcjA-3fddA:
0.0
2hcjB-3fddA:
1.7		 2hcjA-3fddA:
5.93
2hcjB-3fddA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 LEU A 284
ALA A 177
PHE A 250
PHE A 249
 None
 0.97A 2wq5A-3fddA:
undetectable		 2wq5A-3fddA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 VAL A 197
GLY A 200
TYR A 207
ASN A 256
GLN A 232
 None
None
PLP  A 534 (-4.9A)
PLP  A 534 (-3.8A)
None
 1.48A 2zthA-3fddA:
4.2		 2zthA-3fddA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.93A 3abkA-3fddA:
undetectable
3abkJ-3fddA:
undetectable		 3abkA-3fddA:
21.01
3abkJ-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.88A 3ablA-3fddA:
undetectable
3ablJ-3fddA:
undetectable		 3ablA-3fddA:
21.01
3ablJ-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.88A 3abmN-3fddA:
undetectable
3abmW-3fddA:
undetectable		 3abmN-3fddA:
21.01
3abmW-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.90A 3ag3A-3fddA:
undetectable
3ag3J-3fddA:
undetectable		 3ag3A-3fddA:
21.01
3ag3J-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.78A 3ag3N-3fddA:
undetectable
3ag3W-3fddA:
undetectable		 3ag3N-3fddA:
21.01
3ag3W-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.90A 3asnN-3fddA:
undetectable
3asnW-3fddA:
undetectable		 3asnN-3fddA:
21.01
3asnW-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.87A 3asoN-3fddA:
undetectable
3asoW-3fddA:
undetectable		 3asoN-3fddA:
21.01
3asoW-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		3 / 3 ASP A 373
ARG A 369
ALA A 372
 None
 0.59A 3mbgC-3fddA:
1.7		 3mbgC-3fddA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 PHE A 313
VAL A 326
ILE A 152
SER A 144
 None
 0.91A 3pglA-3fddA:
undetectable		 3pglA-3fddA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
 PLP  A 534 (-2.8A)
PLP  A 534 (-3.7A)
None
None
None
 1.12A 4drhA-3fddA:
undetectable		 4drhA-3fddA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
 PLP  A 534 (-2.8A)
PLP  A 534 (-3.7A)
None
None
None
 1.14A 4drhD-3fddA:
undetectable		 4drhD-3fddA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 4 PRO A 118
LEU A 122
ILE A  83
ARG A  86
 None
 1.42A 4f4dA-3fddA:
undetectable		 4f4dA-3fddA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 GLY A 325
GLY A 173
GLY A 174
ALA A 170
VAL A 148
 None
PLP  A 534 (-3.4A)
PLP  A 534 (-3.4A)
None
None
 1.00A 4htfB-3fddA:
3.3		 4htfB-3fddA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
 PLP  A 534 (-2.8A)
PLP  A 534 (-3.7A)
None
None
None
 1.07A 4qt3A-3fddA:
undetectable		 4qt3A-3fddA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 LEU A 130
GLU A  84
ALA A  60
PHE A  57
LEU A 103
 None
 1.15A 4retA-3fddA:
3.2		 4retA-3fddA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 LEU A 130
GLU A  84
ALA A  60
PHE A  57
LEU A 103
 None
 1.16A 4retC-3fddA:
undetectable		 4retC-3fddA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 11 ALA A 179
ALA A 176
VAL A 171
LEU A 284
VAL A 327
 None
 1.27A 5eb5A-3fddA:
undetectable		 5eb5A-3fddA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5eeuP-3fddA:
undetectable
5eeuQ-3fddA:
undetectable		 5eeuP-3fddA:
9.19
5eeuQ-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5eevP-3fddA:
undetectable
5eevQ-3fddA:
undetectable		 5eevP-3fddA:
9.19
5eevQ-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5eewP-3fddA:
undetectable
5eewQ-3fddA:
undetectable		 5eewP-3fddA:
9.19
5eewQ-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5eexP-3fddA:
undetectable
5eexQ-3fddA:
undetectable		 5eexP-3fddA:
9.19
5eexQ-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5eeyP-3fddA:
undetectable
5eeyQ-3fddA:
undetectable		 5eeyP-3fddA:
9.19
5eeyQ-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5eezP-3fddA:
undetectable
5eezQ-3fddA:
undetectable		 5eezP-3fddA:
9.19
5eezQ-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5ef0P-3fddA:
undetectable
5ef0Q-3fddA:
undetectable		 5ef0P-3fddA:
9.19
5ef0Q-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5ef1P-3fddA:
undetectable
5ef1Q-3fddA:
undetectable		 5ef1P-3fddA:
9.19
5ef1Q-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5ef2P-3fddA:
undetectable
5ef2Q-3fddA:
undetectable		 5ef2P-3fddA:
9.19
5ef2Q-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 10 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.35A 5ef3P-3fddA:
undetectable
5ef3Q-3fddA:
undetectable		 5ef3P-3fddA:
9.19
5ef3Q-3fddA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.86A 5iy5A-3fddA:
undetectable
5iy5J-3fddA:
undetectable		 5iy5A-3fddA:
21.01
5iy5J-3fddA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		3 / 3 ASP A 373
ASN A 380
PHE A 335
 None
 0.90A 5jglB-3fddA:
2.7		 5jglB-3fddA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 ILE A 511
ASN A  29
MET A  32
VAL A 482
ILE A 475
 None
 1.13A 5mlmA-3fddA:
undetectable		 5mlmA-3fddA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 6 ARG A  48
ALA A  50
PRO A  47
PHE A 396
 None
 1.07A 5odqA-3fddA:
2.5		 5odqA-3fddA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 6 ASN A 436
ALA A 437
PRO A 254
ASP A 434
 None
 1.19A 5umd2-3fddA:
undetectable
5umdF-3fddA:
undetectable		 5umd2-3fddA:
10.69
5umdF-3fddA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 8 GLY A 318
THR A 320
PHE A 292
TYR A 289
 None
None
None
PLP  A 534 (-4.6A)
 0.98A 6eqpA-3fddA:
undetectable		 6eqpA-3fddA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		5 / 12 ILE A 511
ASN A  29
MET A  32
VAL A 482
ILE A 475
 None
 1.10A 6gsdA-3fddA:
2.1		 6gsdA-3fddA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 6 TYR A  90
ILE A  91
ALA A  50
ARG A  53
 None
None
None
CL  A 536 (-4.3A)
 0.99A 6hu9m-3fddA:
undetectable
6hu9q-3fddA:
1.6		 6hu9m-3fddA:
21.42
6hu9q-3fddA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE
(Comamonas
testosteroni) 		4 / 7 ASP A 159
ARG A 154
GLU A 155
GLU A 404
 None
 1.31A 6mn5E-3fddA:
undetectable		 6mn5E-3fddA:
11.79