SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 305
TYR A 346
ALA A  49
GLY A  46
LEU A 320
 None
 1.11A 1igxA-3fdgA:
undetectable		 1igxA-3fdgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		8 / 12 ASP A  13
TYR A  56
GLU A 137
HIS A 210
HIS A 231
ARG A 242
ASN A 262
ASP A 304
 MG  A 357 (-1.8A)
None
MG  A 357 ( 2.4A)
MG  A 356 (-3.4A)
MG  A 356 (-3.5A)
MG  A 356 ( 4.9A)
None
MG  A 356 ( 4.0A)
 0.24A 1ituA-3fdgA:
44.4		 1ituA-3fdgA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		7 / 12 ASP A  13
TYR A  56
GLU A 137
HIS A 210
HIS A 231
ARG A 242
ASP A 304
 MG  A 357 (-1.8A)
None
MG  A 357 ( 2.4A)
MG  A 356 (-3.4A)
MG  A 356 (-3.5A)
MG  A 356 ( 4.9A)
MG  A 356 ( 4.0A)
 0.22A 1ituB-3fdgA:
44.4		 1ituB-3fdgA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		3 / 3 PHE A 216
LEU A 227
MET A 205
 None
 0.85A 1mx1D-3fdgA:
undetectable		 1mx1D-3fdgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 294
VAL A 259
SER A 255
VAL A 219
LEU A 208
 None
 1.28A 1mx1E-3fdgA:
undetectable		 1mx1E-3fdgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 122
ALA A 118
TYR A 346
ILE A 133
 None
 1.22A 1oniB-3fdgA:
undetectable
1oniC-3fdgA:
undetectable		 1oniB-3fdgA:
16.47
1oniC-3fdgA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 122
ALA A 118
TYR A 346
ILE A 133
 None
 1.22A 1oniH-3fdgA:
undetectable
1oniI-3fdgA:
0.6		 1oniH-3fdgA:
16.47
1oniI-3fdgA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 310
ASP A 306
LEU A  38
PHE A 305
LEU A 320
 None
 1.25A 1rh3A-3fdgA:
undetectable		 1rh3A-3fdgA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 310
ASP A 306
LEU A  38
PHE A 305
LEU A 320
 None
 1.17A 1rx3A-3fdgA:
undetectable		 1rx3A-3fdgA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 GLU A 137
HIS A 135
HIS A 210
HIS A  11
 MG  A 357 ( 2.4A)
None
MG  A 356 (-3.4A)
MG  A 357 (-3.3A)
 0.99A 1v7zD-3fdgA:
undetectable		 1v7zD-3fdgA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 108
ARG A 111
LEU A  18
ILE A  28
PHE A  53
 None
 1.40A 1y0xX-3fdgA:
undetectable		 1y0xX-3fdgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 PHE A 216
ASN A 212
GLU A 186
GLY A 185
 None
 0.92A 1ykiA-3fdgA:
undetectable
1ykiB-3fdgA:
undetectable		 1ykiA-3fdgA:
20.50
1ykiB-3fdgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 7 THR A 230
SER A 159
ASP A 207
LEU A  38
 None
 0.95A 2hdnE-3fdgA:
undetectable
2hdnF-3fdgA:
2.6
2hdnH-3fdgA:
2.6		 2hdnE-3fdgA:
6.90
2hdnF-3fdgA:
21.18
2hdnH-3fdgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 6 ALA A  54
TYR A  56
ASP A  13
HIS A 135
 MG  A 357 ( 4.2A)
None
MG  A 357 (-1.8A)
None
 1.34A 2pncB-3fdgA:
undetectable		 2pncB-3fdgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		3 / 3 GLU A 343
GLN A 324
ARG A 328
 None
 0.90A 2w3bB-3fdgA:
undetectable		 2w3bB-3fdgA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		3 / 3 PHE A  14
ASN A  12
PHE A  53
 None
 1.09A 2zbuD-3fdgA:
undetectable		 2zbuD-3fdgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 ALA A  54
THR A 230
PHE A 263
GLY A  51
LEU A  38
 MG  A 357 ( 4.2A)
None
None
None
None
 1.17A 3aobC-3fdgA:
undetectable		 3aobC-3fdgA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 ALA A  54
THR A 230
PHE A 263
GLY A  51
LEU A  38
 MG  A 357 ( 4.2A)
None
None
None
None
 1.26A 3aodC-3fdgA:
undetectable		 3aodC-3fdgA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 171
VAL A 163
LEU A 211
PRO A 162
 None
 0.89A 3bgdB-3fdgA:
undetectable		 3bgdB-3fdgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  10
ASN A  12
GLY A 302
SER A 303
ASP A 306
 None
 1.07A 3huoB-3fdgA:
undetectable		 3huoB-3fdgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 4 ALA A  49
HIS A 125
HIS A 342
PRO A   6
 None
 1.07A 3mbgA-3fdgA:
0.0		 3mbgA-3fdgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 5 ARG A 122
HIS A 125
GLU A 343
HIS A 342
 None
 1.43A 3mbgB-3fdgA:
0.0
3mbgC-3fdgA:
0.0		 3mbgB-3fdgA:
16.90
3mbgC-3fdgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 5 GLU A 343
HIS A 342
ARG A 122
HIS A 125
 None
 1.40A 3mbgB-3fdgA:
0.0
3mbgC-3fdgA:
0.0		 3mbgB-3fdgA:
16.90
3mbgC-3fdgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 4 ALA A  49
HIS A 125
HIS A 342
PRO A   6
 None
 1.08A 3mbgC-3fdgA:
0.0		 3mbgC-3fdgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 244
LEU A 249
ASN A 262
LEU A 261
LEU A 340
 None
 1.13A 3r9cA-3fdgA:
undetectable		 3r9cA-3fdgA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 5 LEU A  16
HIS A 231
GLU A 137
HIS A 210
 None
MG  A 356 (-3.5A)
MG  A 357 ( 2.4A)
MG  A 356 (-3.4A)
 1.28A 4a7bB-3fdgA:
undetectable		 4a7bB-3fdgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 ASP A 217
ASP A 218
VAL A 196
LEU A 227
 None
 1.02A 4f8hA-3fdgA:
undetectable
4f8hB-3fdgA:
undetectable		 4f8hA-3fdgA:
21.50
4f8hB-3fdgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 ASP A 217
ASP A 218
VAL A 196
LEU A 227
 None
 1.02A 4f8hB-3fdgA:
undetectable
4f8hC-3fdgA:
undetectable		 4f8hB-3fdgA:
21.50
4f8hC-3fdgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 ASP A 217
ASP A 218
VAL A 196
LEU A 227
 None
 1.02A 4f8hC-3fdgA:
undetectable
4f8hD-3fdgA:
undetectable		 4f8hC-3fdgA:
21.50
4f8hD-3fdgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 ASP A 217
ASP A 218
VAL A 196
LEU A 227
 None
 1.02A 4f8hD-3fdgA:
undetectable
4f8hE-3fdgA:
undetectable		 4f8hD-3fdgA:
21.50
4f8hE-3fdgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 VAL A 196
LEU A 227
ASP A 217
ASP A 218
 None
 1.01A 4f8hA-3fdgA:
undetectable
4f8hE-3fdgA:
undetectable		 4f8hA-3fdgA:
21.50
4f8hE-3fdgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 138
GLY A 161
GLU A 140
PHE A 152
ILE A 142
 None
 1.18A 4fglA-3fdgA:
undetectable
4fglB-3fdgA:
undetectable		 4fglA-3fdgA:
20.27
4fglB-3fdgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 11 ILE A 310
ASP A 306
LEU A  38
PHE A 305
LEU A 320
 None
 1.26A 4i1nA-3fdgA:
undetectable		 4i1nA-3fdgA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 9 GLY A 138
GLY A 171
PHE A 170
ARG A 166
GLY A 173
 None
 1.24A 4kqiA-3fdgA:
undetectable		 4kqiA-3fdgA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 ASP A 306
SER A 232
HIS A 231
ASN A  12
SER A 209
 None
None
MG  A 356 (-3.5A)
None
None
 1.36A 4pooB-3fdgA:
undetectable		 4pooB-3fdgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 169
LEU A 188
LEU A 160
LEU A 157
ALA A  94
 None
 1.35A 4rtbA-3fdgA:
4.3		 4rtbA-3fdgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 271
ARG A 285
PRO A 282
 None
 1.08A 4wanC-3fdgA:
undetectable		 4wanC-3fdgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		6 / 12 GLY A 313
LEU A  38
PHE A  53
PHE A  48
ILE A 133
GLY A  51
 None
 1.41A 5fsaB-3fdgA:
undetectable		 5fsaB-3fdgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 219
LEU A 222
LEU A 206
GLY A 187
LEU A 211
 None
 1.10A 5ikrB-3fdgA:
undetectable		 5ikrB-3fdgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 259
VAL A 299
SER A 232
ILE A 310
ALA A 264
 None
 1.06A 5n0sB-3fdgA:
undetectable		 5n0sB-3fdgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 261
GLY A 302
GLY A  10
LEU A 323
MET A 327
 None
 1.16A 5uc1A-3fdgA:
undetectable		 5uc1A-3fdgA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		6 / 12 LEU A 290
GLY A 260
ILE A 291
TYR A 332
LEU A 340
GLY A 300
 None
 1.41A 5wyqB-3fdgA:
undetectable		 5wyqB-3fdgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		5 / 12 MET A 134
LEU A 157
ILE A 142
LEU A  95
ALA A  94
 None
 1.12A 6djzA-3fdgA:
undetectable		 6djzA-3fdgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		3 / 3 LEU A  16
GLY A 307
PHE A 176
 None
 0.55A 6exiC-3fdgA:
undetectable		 6exiC-3fdgA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 215
PHE A 216
GLY A 161
ALA A 229
 None
 0.76A 6hu9H-3fdgA:
undetectable
6hu9e-3fdgA:
undetectable		 6hu9H-3fdgA:
12.46
6hu9e-3fdgA:
15.73