SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ARG A 460
ARG A 229
LEU A 143
ALA A  58
GLY A  60
 None
 1.10A 1cmaA-3fdhA:
undetectable
1cmaB-3fdhA:
undetectable		 1cmaA-3fdhA:
12.96
1cmaB-3fdhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ARG A 460
ARG A 229
LEU A 143
ALA A  58
GLY A  60
 None
 1.09A 1cmcA-3fdhA:
undetectable
1cmcB-3fdhA:
undetectable		 1cmcA-3fdhA:
12.96
1cmcB-3fdhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A  58
GLY A  60
ARG A 460
ARG A 229
LEU A 143
 None
 1.13A 1mj2A-3fdhA:
undetectable
1mj2B-3fdhA:
undetectable		 1mj2A-3fdhA:
12.14
1mj2B-3fdhA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A  58
GLY A  60
ARG A 460
ARG A 229
LEU A 143
 None
 1.08A 1mj2C-3fdhA:
undetectable
1mj2D-3fdhA:
undetectable		 1mj2C-3fdhA:
12.14
1mj2D-3fdhA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A  58
GLY A  60
ARG A 460
ARG A 229
LEU A 143
 None
 1.12A 1mjoC-3fdhA:
undetectable
1mjoD-3fdhA:
undetectable		 1mjoC-3fdhA:
12.14
1mjoD-3fdhA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 111
ILE A 114
LEU A  46
ALA A 133
LEU A 107
 None
 1.13A 1og5B-3fdhA:
undetectable		 1og5B-3fdhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 CYH A 368
LEU A 370
ALA A 366
MET A 228
LEU A 465
 None
 1.27A 1s9pB-3fdhA:
undetectable		 1s9pB-3fdhA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 416
PHE A 343
LEU A 292
SER A 409
 None
 0.99A 1wrlC-3fdhA:
undetectable
1wrlD-3fdhA:
undetectable		 1wrlC-3fdhA:
11.36
1wrlD-3fdhA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 185
THR A 180
TYR A 226
LEU A 186
 None
 1.02A 1z2bB-3fdhA:
undetectable		 1z2bB-3fdhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 366
TYR A 241
ARG A 369
TYR A 179
 None
 1.14A 2ajvH-3fdhA:
undetectable
2ajvL-3fdhA:
undetectable		 2ajvH-3fdhA:
18.69
2ajvL-3fdhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ASN A 140
GLY A  60
THR A 453
THR A  53
THR A 351
 None
 1.44A 2f9wA-3fdhA:
undetectable
2f9wB-3fdhA:
undetectable		 2f9wA-3fdhA:
20.45
2f9wB-3fdhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 485
TYR A 507
ASN A 457
TYR A 487
 None
 1.20A 2w98A-3fdhA:
undetectable
2w98B-3fdhA:
undetectable		 2w98A-3fdhA:
21.58
2w98B-3fdhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 257
TYR A 356
TYR A 208
LEU A 222
 None
 1.09A 2w98A-3fdhA:
undetectable
2w98B-3fdhA:
undetectable		 2w98A-3fdhA:
21.58
2w98B-3fdhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  62
PHE A 148
CYH A 141
ALA A 157
ILE A 103
 None
 1.09A 2xkwB-3fdhA:
undetectable		 2xkwB-3fdhA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 270
TYR A 264
ASN A 388
ALA A 260
 None
 1.41A 3frqB-3fdhA:
undetectable		 3frqB-3fdhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 183
LEU A 186
VAL A 135
ALA A 259
LEU A 353
 None
 1.31A 3ozuA-3fdhA:
undetectable		 3ozuA-3fdhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A  55
TYR A 273
LEU A 207
 None
 0.79A 3sueB-3fdhA:
undetectable		 3sueB-3fdhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 441
ARG A 229
LEU A 362
 None
 1.35A 3v4tE-3fdhA:
undetectable		 3v4tE-3fdhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 443
ARG A 299
PRO A 298
ALA A 300
 None
 1.16A 3vm4A-3fdhA:
undetectable		 3vm4A-3fdhA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 208
PHE A 218
ILE A  50
PRO A 350
ILE A 263
 None
 1.13A 4drhD-3fdhA:
undetectable		 4drhD-3fdhA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 370
ARG A 369
MET A 228
ALA A 224
GLU A 242
 None
 1.36A 4la0A-3fdhA:
undetectable		 4la0A-3fdhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  61
ASN A  57
SER A  94
 None
 0.67A 4obwA-3fdhA:
undetectable		 4obwA-3fdhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 218
TYR A 208
LEU A 207
THR A  53
 None
 1.38A 4paeA-3fdhA:
undetectable		 4paeA-3fdhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 470
HIS A 357
TYR A 420
VAL A 425
 None
 1.28A 4s0vA-3fdhA:
undetectable		 4s0vA-3fdhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  43
ASP A 123
VAL A 128
ASP A 197
 None
 1.30A 4xqeB-3fdhA:
undetectable		 4xqeB-3fdhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 329
THR A  64
TYR A 456
PHE A 459
 None
None
None
PG4  A   1 (-4.6A)
 0.90A 5flcB-3fdhA:
5.4		 5flcB-3fdhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 329
THR A  64
TYR A 456
PHE A 459
 None
None
None
PG4  A   1 (-4.6A)
 0.89A 5flcF-3fdhA:
2.4		 5flcF-3fdhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 378
ALA A 374
LEU A 434
MET A 228
LEU A 245
 None
 1.20A 5hyrB-3fdhA:
undetectable		 5hyrB-3fdhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 292
ALA A 389
PHE A 343
PRO A 325
 None
 0.76A 5m0oC-3fdhA:
undetectable		 5m0oC-3fdhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 205
LEU A 207
TYR A 208
VAL A 135
 None
 1.06A 5ov9B-3fdhA:
undetectable		 5ov9B-3fdhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 302
ALA A 300
ILE A 393
ALA A 389
 None
 0.89A 6ma7A-3fdhA:
undetectable		 6ma7A-3fdhA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 449
ALA A 389
ILE A 397
ALA A 396
 None
 0.89A 6ma7A-3fdhA:
undetectable		 6ma7A-3fdhA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3fdh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ILE A 412
THR A 413
PRO A 298
 None
 0.47A 6ncsA-3fdhA:
undetectable		 6ncsA-3fdhA:
20.86