SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		4 / 8 GLU D  61
GLY D  59
SER D  92
THR D  99
 None
 0.80A 1m4iA-3fdsD:
undetectable		 1m4iA-3fdsD:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 LEU D 225
VAL D 202
VAL D 176
LEU D 154
LEU D 147
 None
 1.45A 1mx1E-3fdsD:
undetectable		 1mx1E-3fdsD:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 GLY D  39
VAL D  19
LEU D  23
LEU D  48
PHE D  71
 None
 1.07A 1mx1F-3fdsD:
undetectable		 1mx1F-3fdsD:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 ALA D 133
LEU D 135
LEU D 178
ILE D 144
LEU D 154
 None
 1.10A 1qzfA-3fdsD:
undetectable		 1qzfA-3fdsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 ALA D 133
LEU D 135
LEU D 178
ILE D 144
LEU D 154
 None
 1.10A 1qzfB-3fdsD:
undetectable		 1qzfB-3fdsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 ALA D 133
LEU D 135
LEU D 178
ILE D 144
LEU D 154
 None
 1.10A 1qzfC-3fdsD:
undetectable		 1qzfC-3fdsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 ALA D 133
LEU D 135
LEU D 178
ILE D 144
LEU D 154
 None
 1.10A 1qzfD-3fdsD:
undetectable		 1qzfD-3fdsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 ALA D 133
LEU D 135
LEU D 178
ILE D 144
LEU D 154
 None
 1.11A 1qzfE-3fdsD:
undetectable		 1qzfE-3fdsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		4 / 7 PHE D  12
LEU D 100
PHE D  57
VAL D  62
 None
 1.10A 1wrlA-3fdsD:
undetectable
1wrlB-3fdsD:
undetectable		 1wrlA-3fdsD:
16.81
1wrlB-3fdsD:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 11 LEU D  48
ILE D  50
LEU D  52
PHE D  51
TYR D 236
 None
 1.27A 2bxmA-3fdsD:
undetectable		 2bxmA-3fdsD:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		4 / 5 PHE D  60
PHE D  57
PHE D  12
VAL D  30
 None
 1.26A 2lh6A-3fdsD:
undetectable		 2lh6A-3fdsD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 9 TYR D  56
PHE D  57
LEU D  16
LEU D 100
ALA D   4
 None
 1.28A 2vcvE-3fdsD:
undetectable		 2vcvE-3fdsD:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 9 TYR D  56
PHE D  57
LEU D  16
LEU D 100
ALA D   4
 None
 1.25A 2vcvI-3fdsD:
undetectable		 2vcvI-3fdsD:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 LEU D  73
LEU D  16
ASN D  77
MET D 208
LEU D  48
 None
 1.48A 2w8yB-3fdsD:
undetectable		 2w8yB-3fdsD:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 12 LEU D  73
LEU D  16
ASN D  77
MET D 208
LEU D  48
 None
 1.47A 3d90A-3fdsD:
undetectable		 3d90A-3fdsD:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 10 PRO D 122
ILE D  40
SER D  38
SER D 119
GLY D  39
 None
 1.10A 3ijxB-3fdsD:
undetectable
3ijxD-3fdsD:
undetectable		 3ijxB-3fdsD:
24.04
3ijxD-3fdsD:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 11 ILE D  40
SER D  38
SER D 119
GLY D  39
PRO D 122
 None
 1.01A 3iluB-3fdsD:
undetectable
3iluE-3fdsD:
undetectable		 3iluB-3fdsD:
24.04
3iluE-3fdsD:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		4 / 8 ILE D  40
SER D  38
GLY D  39
PRO D 122
 None
 0.90A 3lslA-3fdsD:
undetectable
3lslD-3fdsD:
undetectable		 3lslA-3fdsD:
24.04
3lslD-3fdsD:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		4 / 8 PRO D 122
ILE D  40
SER D  38
GLY D  39
 None
 0.92A 3lslA-3fdsD:
undetectable
3lslD-3fdsD:
undetectable		 3lslA-3fdsD:
24.04
3lslD-3fdsD:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		5 / 11 VAL D   6
PHE D  57
ILE D  15
LEU D  91
PHE D  28
 None
 0.72A 3t3rA-3fdsD:
undetectable		 3t3rA-3fdsD:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3fds DNA POLYMERASE
SLIDING CLAMP C
(Sulfolobus
solfataricus) 		4 / 8 LEU D 231
TYR D 236
VAL D  19
THR D  18
 None
 0.95A 4ma7A-3fdsD:
undetectable		 4ma7A-3fdsD:
19.18