SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CLA_A_CLMA221_0 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	5 / 10	THR A 14 PHE A 13 ALA A 111 VAL A 32 ILE A 109	ATP A 301 ( 4.8A) None ATP A 301 (-3.3A) None None	1.22A	1claA-3fdxA: undetectable	1claA-3fdxA: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CIZ_A_ACTA1320_0 (CHLOROPEROXIDASE)	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	4 / 6	ALA A 73 ILE A 18 VAL A 21 GLU A 22	FMT A 402 ( 4.1A) None None None	0.77A	2cizA-3fdxA: undetectable	2cizA-3fdxA: 18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGK_A_0TXA302_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	4 / 6	ILE A 6 PRO A 5 PHE A 34 PHE A 85	None ATP A 301 (-4.2A) None None	1.24A	4fgkA-3fdxA: undetectable	4fgkA-3fdxA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DH0_A_017A101_1 (PROTEASE)	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	5 / 12	ALA A 133 VAL A 108 LEU A 3 VAL A 139 VAL A 137	None	0.72A	6dh0B-3fdxA: undetectable	6dh0B-3fdxA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_A_SAMA501_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	5 / 12	ILE A 2 ILE A 27 ILE A 17 VAL A 140 ILE A 109	None	1.01A	6emuA-3fdxA: 4.1	6emuA-3fdxA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_B_SAMB301_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	5 / 12	ILE A 2 ILE A 27 ILE A 17 VAL A 140 ILE A 109	None	1.02A	6emuB-3fdxA: 3.6	6emuB-3fdxA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_C_SAMC301_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	3fdx	PUTATIVE FILAMENT PROTEIN / UNIVERSAL STRESS PROTEIN F (Klebsiella pneumoniae)	5 / 12	ILE A 2 ILE A 27 ILE A 17 VAL A 140 ILE A 109	None	1.02A	6emuC-3fdxA: 3.6	6emuC-3fdxA: 21.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CLA_A_CLMA221_0","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",5,"THR A  14;PHE A  13;ALA A 111;VAL A  32;ILE A 109","ATP A 301 ( 4.8A);None;ATP A 301 (-3.3A);None;None","1.22A","1claA-3fdxA:undetectable","1claA-3fdxA:23.12"],["2CIZ_A_ACTA1320_0","CHLOROPEROXIDASE","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",4,"ALA A  73;ILE A  18;VAL A  21;GLU A  22","FMT A 402 ( 4.1A);None;None;None","0.77A","2cizA-3fdxA:undetectable","2cizA-3fdxA:18.27"],["4FGK_A_0TXA302_0","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",4,"ILE A   6;PRO A   5;PHE A  34;PHE A  85","None;ATP A 301 (-4.2A);None;None","1.24A","4fgkA-3fdxA:undetectable","4fgkA-3fdxA:23.08"],["6DH0_A_017A101_1","PROTEASE","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",5,"ALA A 133;VAL A 108;LEU A   3;VAL A 139;VAL A 137","None","0.72A","6dh0B-3fdxA:undetectable","6dh0B-3fdxA:18.75"],["6EMU_A_SAMA501_0","TRNA (GUANINE(9)-\/ADENINE(9)-N1)-METHYLTRANSFERASE","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",5,"ILE A   2;ILE A  27;ILE A  17;VAL A 140;ILE A 109","None","1.01A","6emuA-3fdxA:4.1","6emuA-3fdxA:21.84"],["6EMU_B_SAMB301_0","TRNA (GUANINE(9)-\/ADENINE(9)-N1)-METHYLTRANSFERASE","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",5,"ILE A   2;ILE A  27;ILE A  17;VAL A 140;ILE A 109","None","1.02A","6emuB-3fdxA:3.6","6emuB-3fdxA:21.84"],["6EMU_C_SAMC301_0","TRNA (GUANINE(9)-\/ADENINE(9)-N1)-METHYLTRANSFERASE","3fdx","PUTATIVE FILAMENT PROTEIN \/ UNIVERSAL STRESS PROTEIN F","Klebsiella pneumoniae",5,"ILE A   2;ILE A  27;ILE A  17;VAL A 140;ILE A 109","None","1.02A","6emuC-3fdxA:3.6","6emuC-3fdxA:21.84"]]