SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fe1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 12 ASN A 362
ASP A 335
ILE A 214
ASP A 188
GLY A 186
 None
 1.48A 1q8jA-3fe1A:
2.7		 1q8jA-3fe1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 12 GLY A 232
GLY A 204
GLY A 205
LEU A 230
ASN A 237
 ADP  A 386 (-3.3A)
ADP  A 386 (-3.2A)
None
None
None
 0.83A 1qzzA-3fe1A:
undetectable		 1qzzA-3fe1A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 12 GLY A 232
GLY A 204
GLY A 205
LEU A 230
ASN A 237
 ADP  A 386 (-3.3A)
ADP  A 386 (-3.2A)
None
None
None
 0.89A 1xdsA-3fe1A:
undetectable		 1xdsA-3fe1A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 12 GLY A 232
GLY A 204
GLY A 205
LEU A 230
ASN A 237
 ADP  A 386 (-3.3A)
ADP  A 386 (-3.2A)
None
None
None
 0.85A 1xdsB-3fe1A:
undetectable		 1xdsB-3fe1A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A 255
GLY A 257
LEU A 289
SER A 288
ALA A 261
 None
 0.93A 2v3kA-3fe1A:
undetectable		 2v3kA-3fe1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 12 ILE A 299
LEU A 276
ILE A 345
PRO A 346
PHE A 312
 None
None
ADP  A 386 (-4.8A)
None
None
 1.06A 2ygqA-3fe1A:
undetectable		 2ygqA-3fe1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 6 PHE A 200
PHE A 207
THR A 343
VAL A 348
 None
 1.31A 3lb3A-3fe1A:
2.2		 3lb3A-3fe1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 6 PHE A 200
PHE A 207
THR A 343
VAL A 348
 None
 1.33A 3lb3B-3fe1A:
undetectable		 3lb3B-3fe1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 10 ILE A 214
ALA A 180
ILE A 199
VAL A 337
VAL A 197
 None
 0.87A 3me6A-3fe1A:
undetectable		 3me6A-3fe1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 8 ILE A 214
ALA A 180
VAL A 337
VAL A 197
 None
 0.82A 3me6B-3fe1A:
undetectable		 3me6B-3fe1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A  44
GLY A  54
LYS A  58
 None
 0.76A 4k50I-3fe1A:
undetectable		 4k50I-3fe1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 7 ILE A 333
PHE A 356
LEU A 323
ASP A 329
 None
 1.10A 4mmcA-3fe1A:
0.9		 4mmcA-3fe1A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A 230
LEU A 202
VAL A 319
LEU A 198
VAL A 336
 None
 1.18A 4po0A-3fe1A:
2.7		 4po0A-3fe1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 7 GLU A 177
THR A  15
GLY A  14
THR A  16
 PO4  A 387 (-2.9A)
PO4  A 387 ( 3.4A)
PO4  A 387 (-3.1A)
ADP  A 386 (-3.4A)
 0.93A 4qwpB-3fe1A:
undetectable		 4qwpB-3fe1A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 ADP  A 386 (-3.0A)
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 1.06A 5aqfA-3fe1A:
21.3		 5aqfA-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
SER A 342
ARG A 344
ILE A 345
 ADP  A 386 (-3.0A)
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
ADP  A 386 (-4.8A)
 1.19A 5aqfA-3fe1A:
21.3		 5aqfA-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
GLU A 270
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 ADP  A 386 (-3.2A)
ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 0.59A 5aqfA-3fe1A:
21.3		 5aqfA-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 340
SER A 342
ILE A 345
 ADP  A 386 (-3.2A)
ADP  A 386 (-3.3A)
ADP  A 386 (-3.3A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 0.94A 5aqfA-3fe1A:
21.3		 5aqfA-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 None
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 1.28A 5aqfA-3fe1A:
21.3		 5aqfA-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		6 / 10 GLY A 232
GLU A 270
LYS A 273
ARG A 274
SER A 277
ILE A 345
 ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
None
ADP  A 386 (-2.6A)
ADP  A 386 (-4.8A)
 1.31A 5aqfA-3fe1A:
21.3		 5aqfA-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		6 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
ARG A 344
ILE A 345
 ADP  A 386 (-3.0A)
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-4.8A)
ADP  A 386 (-4.8A)
 1.22A 5aqfC-3fe1A:
55.1		 5aqfC-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 ADP  A 386 (-3.0A)
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 1.06A 5aqfC-3fe1A:
55.1		 5aqfC-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
GLU A 270
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 ADP  A 386 (-3.2A)
ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 0.58A 5aqfC-3fe1A:
55.1		 5aqfC-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 None
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 1.27A 5aqfC-3fe1A:
55.1		 5aqfC-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		6 / 10 GLY A 232
GLU A 270
LYS A 273
ARG A 274
SER A 277
ILE A 345
 ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
None
ADP  A 386 (-2.6A)
ADP  A 386 (-4.8A)
 1.30A 5aqfC-3fe1A:
55.1		 5aqfC-3fe1A:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 ADP  A 386 (-3.0A)
ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 1.05A 5aqyA-3fe1A:
21.9		 5aqyA-3fe1A:
84.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
GLU A 270
LYS A 273
SER A 277
GLY A 341
SER A 342
ILE A 345
 ADP  A 386 (-3.2A)
ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 0.59A 5aqyA-3fe1A:
21.9		 5aqyA-3fe1A:
84.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		7 / 10 GLY A 231
GLY A 232
GLU A 270
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
 1.31A 5aqyA-3fe1A:
21.9		 5aqyA-3fe1A:
84.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		6 / 10 GLY A 232
GLU A 270
LYS A 273
ARG A 274
SER A 277
ILE A 345
 ADP  A 386 (-3.3A)
ADP  A 386 (-3.7A)
ADP  A 386 (-2.8A)
None
ADP  A 386 (-2.6A)
ADP  A 386 (-4.8A)
 1.29A 5aqyA-3fe1A:
21.9		 5aqyA-3fe1A:
84.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		6 / 10 GLY A 232
LYS A 273
SER A 277
SER A 342
ARG A 344
ILE A 345
 ADP  A 386 (-3.3A)
ADP  A 386 (-2.8A)
ADP  A 386 (-2.6A)
ADP  A 386 (-4.1A)
ADP  A 386 (-4.8A)
ADP  A 386 (-4.8A)
 0.81A 5aqyA-3fe1A:
21.9		 5aqyA-3fe1A:
84.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 12 PHE A 235
GLY A 203
GLY A 341
ILE A 345
LEU A 239
 None
ADP  A 386 (-3.0A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.8A)
None
 1.05A 5ul4A-3fe1A:
undetectable		 5ul4A-3fe1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		5 / 9 GLY A 205
GLY A 231
TYR A  17
VAL A 348
GLU A 177
 None
None
ADP  A 386 (-4.5A)
None
PO4  A 387 (-2.9A)
 1.38A 6gnfA-3fe1A:
undetectable		 6gnfA-3fe1A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 4 LYS A 222
LEU A 328
ALA A 223
LEU A 323
 None
 1.47A 6gnrA-3fe1A:
undetectable		 6gnrA-3fe1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens) 		4 / 4 LYS A 222
LEU A 328
ALA A 223
LEU A 323
 None
 1.45A 6gnrB-3fe1A:
undetectable		 6gnrB-3fe1A:
15.91