SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fe2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 7 PRO A 117
ALA A  99
PHE A 101
PHE A  96
 ADP  A 308 ( 4.8A)
None
None
ADP  A 308 (-4.9A)
 0.97A 1lqtA-3fe2A:
undetectable		 1lqtA-3fe2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 7 PRO A 117
ALA A  99
PHE A 101
PHE A  96
 ADP  A 308 ( 4.8A)
None
None
ADP  A 308 (-4.9A)
 0.96A 1lquA-3fe2A:
undetectable		 1lquA-3fe2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 8 ILE A 220
VAL A 183
TYR A 190
CYH A 191
 None
 1.20A 2xz5A-3fe2A:
undetectable
2xz5C-3fe2A:
undetectable		 2xz5A-3fe2A:
20.99
2xz5C-3fe2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 8 ILE A 220
VAL A 183
TYR A 190
CYH A 191
 None
 1.24A 2xz5C-3fe2A:
undetectable
2xz5D-3fe2A:
undetectable		 2xz5C-3fe2A:
20.99
2xz5D-3fe2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		5 / 12 LEU A 289
LEU A 149
ILE A 262
VAL A 183
ILE A 220
 None
 0.97A 3frqB-3fe2A:
undetectable		 3frqB-3fe2A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 8 VAL A 183
TYR A 190
CYH A 191
ILE A 220
 None
 1.06A 4afgD-3fe2A:
0.0
4afgE-3fe2A:
undetectable		 4afgD-3fe2A:
19.10
4afgE-3fe2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 8 VAL A 183
TYR A 190
CYH A 191
ILE A 220
 None
 1.33A 4bqtC-3fe2A:
undetectable
4bqtD-3fe2A:
undetectable		 4bqtC-3fe2A:
20.99
4bqtD-3fe2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		3 / 3 GLY A 226
PRO A 225
ALA A 174
 SO4  A   3 (-3.5A)
SO4  A   3 ( 4.3A)
None
 0.47A 4qn9B-3fe2A:
undetectable		 4qn9B-3fe2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		5 / 9 ILE A 169
GLY A 167
THR A 237
GLN A 274
LEU A 232
 None
 1.43A 5fhzB-3fe2A:
4.3		 5fhzB-3fe2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens) 		4 / 5 GLY A 167
ASN A 238
ARG A 241
ARG A 240
 None
 1.32A 6dwdB-3fe2A:
undetectable
6dwdD-3fe2A:
undetectable		 6dwdB-3fe2A:
20.53
6dwdD-3fe2A:
20.53