SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fe3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 9 GLY A  63
VAL A  70
ALA A  83
TYR A 134
ALA A 135
LEU A 185
 None
 0.70A 1muoA-3fe3A:
23.8		 1muoA-3fe3A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
MET A 107
VAL A 116
GLY A 138
ALA A 195
 None
 0.70A 1opjB-3fe3A:
21.7		 1opjB-3fe3A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 8 GLY A 296
GLU A 233
GLU A 222
ILE A 301
 None
 0.77A 1pk7B-3fe3A:
undetectable		 1pk7B-3fe3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 6 ILE A  62
VAL A  70
ILE A 115
ILE A 174
 None
 0.66A 1uwhA-3fe3A:
23.2		 1uwhA-3fe3A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 6 ILE A  62
VAL A  70
ILE A 115
ILE A 174
 None
 0.66A 1uwhB-3fe3A:
23.2		 1uwhB-3fe3A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 11 GLY A  63
VAL A  70
ALA A  83
MET A 132
TYR A 134
ALA A 135
 None
 0.60A 2evaA-3fe3A:
20.9		 2evaA-3fe3A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		5 / 12 ILE A 307
LEU A 283
ASN A 282
ASN A 308
VAL A 236
 None
 1.05A 2nnhA-3fe3A:
undetectable		 2nnhA-3fe3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		3 / 3 ARG A 295
GLN A 225
PRO A 221
 None
 0.58A 2qhfA-3fe3A:
undetectable		 2qhfA-3fe3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
MET A 107
VAL A 116
LEU A 185
ALA A 195
 None
 0.76A 3pyyB-3fe3A:
15.7		 3pyyB-3fe3A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 5 LYS A  85
VAL A 116
LEU A 185
ASP A 196
 None
 0.94A 3wzdA-3fe3A:
18.4		 3wzdA-3fe3A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		5 / 9 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
 0.88A 3zosA-3fe3A:
22.3		 3zosA-3fe3A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		5 / 9 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
 0.89A 3zosB-3fe3A:
15.5		 3zosB-3fe3A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 5 VAL A  70
ILE A 115
TYR A 134
ILE A 194
 None
 0.82A 4c8bA-3fe3A:
21.7		 4c8bA-3fe3A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		8 / 12 VAL A  70
ALA A  83
ILE A 106
MET A 107
VAL A 116
TYR A 134
LEU A 185
ALA A 195
 None
 0.91A 4csvA-3fe3A:
22.6		 4csvA-3fe3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		7 / 12 GLY A  63
VAL A  70
ALA A  83
LYS A  85
LEU A 118
LEU A 130
GLY A 138
 None
 0.63A 4ifgA-3fe3A:
23.9		 4ifgA-3fe3A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 10 ILE A  62
ALA A  83
VAL A 116
MET A 132
LEU A 185
ASP A 196
 None
 1.01A 4ks8A-3fe3A:
22.4		 4ks8A-3fe3A:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 8 GLY A  65
VAL A  70
ALA A  83
MET A 132
 None
 0.22A 4l9iB-3fe3A:
18.6		 4l9iB-3fe3A:
24.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 6 VAL A  70
ALA A  83
LYS A  85
LEU A 185
 None
 0.79A 4o0uA-3fe3A:
24.1		 4o0uA-3fe3A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		7 / 12 VAL A  70
LYS A  85
VAL A 116
TYR A 134
GLY A 138
LEU A 185
ALA A 195
 None
 1.03A 4otwA-3fe3A:
18.9		 4otwA-3fe3A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		4 / 5 ASN A  55
LEU A  77
HIS A  75
GLU A 356
 None
 1.30A 4p6sA-3fe3A:
undetectable		 4p6sA-3fe3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		7 / 12 ILE A  62
GLY A  63
VAL A  70
ALA A  83
MET A 132
TYR A 134
LEU A 185
 None
 0.76A 4qmzA-3fe3A:
23.0		 4qmzA-3fe3A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 10 VAL A  70
LEU A 110
ILE A 115
VAL A 116
TYR A 134
ILE A 194
 None
 0.85A 4u0iA-3fe3A:
22.1		 4u0iA-3fe3A:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 11 VAL A  70
ALA A  83
VAL A 116
TYR A 134
ALA A 135
GLU A 182
 None
 0.60A 5lvnA-3fe3A:
17.8		 5lvnA-3fe3A:
32.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		5 / 9 ILE A  62
GLY A  63
VAL A  70
ALA A  83
MET A 132
 None
 0.56A 5lw1B-3fe3A:
22.5		 5lw1B-3fe3A:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		6 / 10 VAL A  70
ALA A  83
VAL A 116
MET A 132
TYR A 134
LEU A 185
 None
 0.84A 5n3hA-3fe3A:
21.1		 5n3hA-3fe3A:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
MET A 107
TYR A 134
ALA A 135
GLY A 138
ALA A 195
 None
 0.83A 5zv2A-3fe3A:
19.0		 5zv2A-3fe3A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
LYS A  85
MET A 107
ALA A 135
GLY A 138
ALA A 195
 None
 0.88A 5zv2B-3fe3A:
22.2		 5zv2B-3fe3A:
11.89