SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fe5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		3 / 3 ASP A 252
LEU A 246
LEU A 248
 None
 0.77A 1np1B-3fe5A:
undetectable		 1np1B-3fe5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		4 / 4 LEU A 102
VAL A 103
ILE A 104
TRP A 231
 None
 1.30A 1s9qB-3fe5A:
undetectable		 1s9qB-3fe5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		5 / 12 GLY A  51
SER A 209
LEU A  32
LEU A 137
LEU A  84
 None
None
None
CSO  A 134 ( 4.6A)
None
 1.15A 1zgyA-3fe5A:
undetectable		 1zgyA-3fe5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		4 / 8 SER A 219
TYR A 262
VAL A 275
LEU A 273
 None
 1.07A 3jq7C-3fe5A:
undetectable		 3jq7C-3fe5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		3 / 3 ARG A 108
LYS A  33
ARG A 107
 CSO  A 134 ( 4.3A)
None
None
 1.35A 3w1wA-3fe5A:
undetectable
3w1wB-3fe5A:
undetectable		 3w1wA-3fe5A:
20.79
3w1wB-3fe5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		3 / 3 ARG A 107
ARG A 108
LYS A  33
 None
CSO  A 134 ( 4.3A)
None
 1.39A 3w1wA-3fe5A:
undetectable
3w1wB-3fe5A:
undetectable		 3w1wA-3fe5A:
20.79
3w1wB-3fe5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		3 / 3 TYR A 262
ARG A 266
HIS A 214
 None
 1.26A 4fubA-3fe5A:
undetectable		 4fubA-3fe5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		6 / 7 HIS A  47
GLU A  53
HIS A  91
PRO A  93
VAL A 103
GLU A 105
 FE  A   1 (-3.2A)
FE  A   1 (-1.9A)
FE  A   1 (-3.2A)
None
None
FE  A   1 ( 4.5A)
 0.40A 4hvrA-3fe5A:
17.8		 4hvrA-3fe5A:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		4 / 6 ARG A  43
GLU A  53
ARG A 108
GLU A  49
 None
FE  A   1 (-1.9A)
CSO  A 134 ( 4.3A)
None
 1.30A 4kr3A-3fe5A:
undetectable		 4kr3A-3fe5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		4 / 7 GLU A  49
GLU A 112
GLU A  52
GLU A 208
 None
 1.37A 4r87I-3fe5A:
undetectable		 4r87I-3fe5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE
(Bos
taurus) 		4 / 7 LEU A 116
ARG A  43
VAL A 103
GLU A  53
 None
None
None
FE  A   1 (-1.9A)
 1.31A 5umwA-3fe5A:
undetectable
5umwF-3fe5A:
undetectable		 5umwA-3fe5A:
13.57
5umwF-3fe5A:
13.57