SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fed'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.25A 1db1A-3fedA:
undetectable		 1db1A-3fedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 5 GLU A 415
ARG A 524
ASP A 455
THR A 528
 ZN  A1751 ( 1.9A)
BIX  A   1 ( 3.1A)
None
None
 1.04A 1k4tA-3fedA:
undetectable		 1k4tA-3fedA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 TYR A 542
TYR A 224
GLU A 547
HIS A 367
 BIX  A   1 (-4.7A)
None
None
ZN  A1752 ( 3.3A)
 1.11A 1nx9A-3fedA:
3.2		 1nx9A-3fedA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 TYR A 542
TYR A 224
GLU A 547
HIS A 367
 BIX  A   1 (-4.7A)
None
None
ZN  A1752 ( 3.3A)
 1.12A 1nx9B-3fedA:
3.4		 1nx9B-3fedA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 TYR A 542
TYR A 224
GLU A 547
HIS A 367
 BIX  A   1 (-4.7A)
None
None
ZN  A1752 ( 3.3A)
 1.11A 1nx9C-3fedA:
3.7		 1nx9C-3fedA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 TYR A 542
TYR A 224
GLU A 547
HIS A 367
 BIX  A   1 (-4.7A)
None
None
ZN  A1752 ( 3.3A)
 1.13A 1nx9D-3fedA:
2.9		 1nx9D-3fedA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.25A 1rk3A-3fedA:
undetectable		 1rk3A-3fedA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 5 GLU A 415
ARG A 524
ASP A 455
THR A 528
 ZN  A1751 ( 1.9A)
BIX  A   1 ( 3.1A)
None
None
 1.13A 1rr8C-3fedA:
undetectable		 1rr8C-3fedA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 5 GLU A 415
ARG A 524
ASP A 455
THR A 528
 ZN  A1751 ( 1.9A)
BIX  A   1 ( 3.1A)
None
None
 1.09A 1rrjA-3fedA:
0.0		 1rrjA-3fedA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 1v54A-3fedA:
3.1
1v54C-3fedA:
2.9		 1v54A-3fedA:
21.70
1v54C-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.43A 1v54N-3fedA:
2.9
1v54P-3fedA:
2.9		 1v54N-3fedA:
21.70
1v54P-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.46A 1v55A-3fedA:
undetectable
1v55C-3fedA:
3.0		 1v55A-3fedA:
21.70
1v55C-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		3 / 3 VAL A 101
VAL A 348
TRP A 424
 None
 0.91A 1w5uA-3fedA:
undetectable
1w5uB-3fedA:
undetectable		 1w5uA-3fedA:
1.78
1w5uB-3fedA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 5 PRO A 221
GLY A 288
ASN A 290
GLY A 240
 None
 1.09A 1zlqA-3fedA:
undetectable		 1zlqA-3fedA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 ALA A  74
ASP A 412
GLY A  75
ALA A 413
PHE A 416
 None
 1.04A 2c49A-3fedA:
undetectable		 2c49A-3fedA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.45A 2dyrA-3fedA:
undetectable
2dyrC-3fedA:
3.0		 2dyrA-3fedA:
21.70
2dyrC-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 2dyrN-3fedA:
undetectable
2dyrP-3fedA:
2.9		 2dyrN-3fedA:
21.70
2dyrP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 2eijA-3fedA:
2.7
2eijC-3fedA:
3.0		 2eijA-3fedA:
21.70
2eijC-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 2eijN-3fedA:
undetectable
2eijP-3fedA:
2.9		 2eijN-3fedA:
21.70
2eijP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.45A 2eikA-3fedA:
undetectable
2eikC-3fedA:
2.9		 2eikA-3fedA:
21.70
2eikC-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.45A 2eikN-3fedA:
undetectable
2eikP-3fedA:
2.9		 2eikN-3fedA:
21.70
2eikP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.42A 2eilA-3fedA:
2.9
2eilC-3fedA:
2.9		 2eilA-3fedA:
21.70
2eilC-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.45A 2eilN-3fedA:
undetectable
2eilP-3fedA:
2.9		 2eilN-3fedA:
21.70
2eilP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		3 / 3 VAL A 348
TRP A 424
VAL A 101
 None
 0.95A 2izqC-3fedA:
undetectable
2izqD-3fedA:
undetectable		 2izqC-3fedA:
1.78
2izqD-3fedA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 THR A  68
LEU A 551
TYR A 556
THR A 548
ALA A 375
 None
None
NAG  A1758 (-3.4A)
None
None
 1.26A 2npnA-3fedA:
undetectable		 2npnA-3fedA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		3 / 3 ILE A 440
ILE A 388
LEU A 432
 None
 0.58A 2prgA-3fedA:
undetectable		 2prgA-3fedA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 THR A 379
ILE A  86
SER A 410
PHE A  67
HIS A  72
 None
 1.28A 2vdyB-3fedA:
undetectable		 2vdyB-3fedA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 11 SER A 509
TYR A 542
GLY A 508
PHE A 199
ARG A 200
 ZN  A1752 ( 4.9A)
BIX  A   1 (-4.7A)
BIX  A   1 (-3.4A)
BIX  A   1 ( 4.8A)
BIX  A   1 (-2.7A)
 1.22A 2xf3B-3fedA:
undetectable		 2xf3B-3fedA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 10 SER A 509
TYR A 542
GLY A 508
PHE A 199
ARG A 200
 ZN  A1752 ( 4.9A)
BIX  A   1 (-4.7A)
BIX  A   1 (-3.4A)
BIX  A   1 ( 4.8A)
BIX  A   1 (-2.7A)
 1.23A 2xh9B-3fedA:
undetectable		 2xh9B-3fedA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.43A 2y69A-3fedA:
undetectable
2y69C-3fedA:
3.0		 2y69A-3fedA:
21.70
2y69C-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 ARG A  65
GLY A 374
PRO A 138
GLY A 140
 None
 0.92A 2y6rB-3fedA:
undetectable		 2y6rB-3fedA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 TYR A 677
ASN A 252
GLY A 253
GLU A 512
 None
 0.95A 2ys6A-3fedA:
undetectable		 2ys6A-3fedA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.39A 2zd1A-3fedA:
0.5		 2zd1A-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.22A 2zlcA-3fedA:
undetectable		 2zlcA-3fedA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 ILE A 440
SER A 436
ARG A 663
SER A 522
 None
 1.09A 2zw9B-3fedA:
undetectable		 2zw9B-3fedA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.45A 3abkA-3fedA:
3.2
3abkC-3fedA:
3.0		 3abkA-3fedA:
21.70
3abkC-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.42A 3abkN-3fedA:
undetectable
3abkP-3fedA:
3.0		 3abkN-3fedA:
21.70
3abkP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.43A 3abmN-3fedA:
3.0
3abmP-3fedA:
2.9		 3abmN-3fedA:
21.70
3abmP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.43A 3ag2A-3fedA:
undetectable
3ag2C-3fedA:
2.9		 3ag2A-3fedA:
21.70
3ag2C-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.43A 3ag2N-3fedA:
undetectable
3ag2P-3fedA:
2.9		 3ag2N-3fedA:
21.70
3ag2P-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.46A 3ag3A-3fedA:
undetectable
3ag3C-3fedA:
3.0		 3ag3A-3fedA:
21.70
3ag3C-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.42A 3ag3N-3fedA:
undetectable
3ag3P-3fedA:
3.0		 3ag3N-3fedA:
21.70
3ag3P-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 3ag4A-3fedA:
undetectable
3ag4C-3fedA:
3.0		 3ag4A-3fedA:
21.70
3ag4C-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.45A 3ag4N-3fedA:
undetectable
3ag4P-3fedA:
2.9		 3ag4N-3fedA:
21.70
3ag4P-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 4 GLU A 414
GLY A 420
THR A 422
GLU A 423
 BIX  A   1 ( 2.7A)
None
None
CA  A1755 (-2.2A)
 1.01A 3e9xA-3fedA:
undetectable		 3e9xA-3fedA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 ARG A 517
LEU A 518
ILE A 440
GLY A 365
ILE A 520
 None
 1.12A 3ekqB-3fedA:
undetectable		 3ekqB-3fedA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 11 HIS A 679
LEU A 661
ALA A 593
LEU A 622
PHE A 629
 None
 1.15A 3jwqB-3fedA:
undetectable
3jwqC-3fedA:
undetectable		 3jwqB-3fedA:
17.98
3jwqC-3fedA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 11 HIS A 679
LEU A 661
ALA A 593
PHE A 629
THR A 735
 None
 1.24A 3jwqB-3fedA:
undetectable
3jwqC-3fedA:
undetectable		 3jwqB-3fedA:
17.98
3jwqC-3fedA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TYR A 346
GLU A 266
LEU A 100
LYS A  84
 None
 1.29A 3k8mB-3fedA:
undetectable		 3k8mB-3fedA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 6 LEU A 459
PHE A 585
ILE A 437
ALA A 438
 None
 1.08A 3mdrA-3fedA:
undetectable		 3mdrA-3fedA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 TYR A 166
GLU A 293
ILE A 294
ALA A 292
ILE A 120
 None
 1.21A 3ndiA-3fedA:
undetectable		 3ndiA-3fedA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 10 VAL A 204
ALA A 156
VAL A 336
MET A 334
ILE A 215
 None
 1.43A 3retA-3fedA:
undetectable
3retB-3fedA:
0.6		 3retA-3fedA:
9.73
3retB-3fedA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 ASN A 168
ASP A 223
SER A 537
ASP A 220
 None
 1.15A 3sg9B-3fedA:
undetectable		 3sg9B-3fedA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		6 / 12 THR A 379
GLY A 381
GLY A 366
HIS A 367
SER A 445
GLN A 563
 None
None
None
ZN  A1752 ( 3.3A)
None
None
 1.14A 3tkaA-3fedA:
undetectable		 3tkaA-3fedA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.27A 3vt3A-3fedA:
undetectable		 3vt3A-3fedA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.19A 3vt7A-3fedA:
undetectable		 3vt7A-3fedA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 6 PHE A 665
ALA A 664
ALA A 733
LEU A 661
 None
 1.07A 4dtzB-3fedA:
undetectable		 4dtzB-3fedA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.34A 4iclA-3fedA:
0.5		 4iclA-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.34A 4id5A-3fedA:
undetectable		 4id5A-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.37A 4idkA-3fedA:
0.5		 4idkA-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.36A 4ifvA-3fedA:
1.8		 4ifvA-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.34A 4ifyA-3fedA:
undetectable		 4ifyA-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 ALA A 413
LEU A 107
TYR A 109
TRP A 411
 None
 0.89A 4iomA-3fedA:
2.9		 4iomA-3fedA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 ALA A 413
LEU A 107
TYR A 109
TRP A 411
 None
 0.93A 4jjkA-3fedA:
undetectable		 4jjkA-3fedA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 PRO A 233
VAL A 144
TYR A 141
PRO A  71
PHE A 373
 None
 1.37A 4kfbA-3fedA:
undetectable		 4kfbA-3fedA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 10 THR A 468
ALA A 572
ILE A 388
VAL A 384
ALA A 525
 None
 0.96A 4lbgA-3fedA:
undetectable		 4lbgA-3fedA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 THR A 468
ALA A 572
ILE A 388
VAL A 384
ALA A 525
 None
 1.08A 4lbgB-3fedA:
undetectable		 4lbgB-3fedA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 ALA A 210
ILE A 215
GLY A 214
ILE A 213
ILE A 184
 None
 1.13A 4nptA-3fedA:
undetectable		 4nptA-3fedA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 6 GLU A 447
ASP A 377
GLU A 414
ARG A 200
 None
ZN  A1751 (-2.5A)
BIX  A   1 ( 2.7A)
BIX  A   1 (-2.7A)
 0.96A 4ntxA-3fedA:
2.8
4ntxC-3fedA:
undetectable		 4ntxA-3fedA:
21.52
4ntxC-3fedA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 LEU A 577
LEU A  51
LEU A 467
ILE A  47
 None
 1.03A 4okwA-3fedA:
undetectable		 4okwA-3fedA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 11 HIS A 367
ASP A 377
GLU A 414
GLU A 415
HIS A 543
 ZN  A1752 ( 3.3A)
ZN  A1751 (-2.5A)
BIX  A   1 ( 2.7A)
ZN  A1751 ( 1.9A)
ZN  A1751 ( 3.2A)
 0.44A 4pqaA-3fedA:
19.5		 4pqaA-3fedA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 ALA A 521
LEU A 736
LEU A 459
ASN A 586
LEU A 661
 None
 1.37A 4x30A-3fedA:
undetectable		 4x30A-3fedA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 LEU A 299
GLY A 322
ILE A 216
MET A 334
VAL A 165
 None
 1.47A 4x3mA-3fedA:
2.4		 4x3mA-3fedA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 11 ALA A 425
VAL A 105
ASP A 104
TYR A 103
GLY A 261
 None
 1.28A 4xp4A-3fedA:
undetectable		 4xp4A-3fedA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 5b1aN-3fedA:
2.7
5b1aP-3fedA:
3.0		 5b1aN-3fedA:
21.70
5b1aP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.46A 5b1bN-3fedA:
undetectable
5b1bP-3fedA:
2.9		 5b1bN-3fedA:
21.70
5b1bP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 5b3sN-3fedA:
undetectable
5b3sP-3fedA:
2.9		 5b3sN-3fedA:
21.70
5b3sP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.48A 5iy5A-3fedA:
undetectable
5iy5C-3fedA:
2.9		 5iy5A-3fedA:
21.70
5iy5C-3fedA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 6 GLU A 142
PRO A 137
GLY A 140
PHE A 373
 None
 1.13A 5jcnB-3fedA:
undetectable		 5jcnB-3fedA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 GLY A 420
ALA A  74
LEU A 107
GLY A 366
ASP A 510
 None
 0.91A 5kb5A-3fedA:
undetectable		 5kb5A-3fedA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 ARG A 517
LEU A 518
ILE A 440
GLY A 365
ILE A 520
 None
 1.10A 5kqxB-3fedA:
undetectable		 5kqxB-3fedA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 9 ARG A 517
LEU A 518
ILE A 440
GLY A 365
ILE A 520
 None
 1.03A 5kr2D-3fedA:
undetectable		 5kr2D-3fedA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 5 TYR A 289
ALA A 242
GLN A 244
THR A 544
 None
 1.38A 5n0tA-3fedA:
undetectable		 5n0tA-3fedA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 LEU A  73
THR A  76
VAL A 144
TYR A 141
THR A 548
 None
 1.27A 5v1tA-3fedA:
undetectable		 5v1tA-3fedA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 THR A  76
ASN A 146
VAL A 144
TYR A 141
THR A 548
 None
 1.27A 5v1tA-3fedA:
undetectable		 5v1tA-3fedA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.43A 5x1fN-3fedA:
undetectable
5x1fP-3fedA:
2.9		 5x1fN-3fedA:
21.70
5x1fP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.48A 5zcqN-3fedA:
undetectable
5zcqP-3fedA:
2.9		 5zcqN-3fedA:
21.70
5zcqP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 10 LEU A 661
ALA A 633
PRO A 458
PHE A 695
VAL A 626
 None
 1.35A 6b89B-3fedA:
0.2		 6b89B-3fedA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		5 / 12 SER A 421
ASN A 250
ASN A 247
ASP A 510
GLY A 508
 None
None
BIX  A   1 (-3.2A)
None
BIX  A   1 (-3.4A)
 1.17A 6dwnA-3fedA:
undetectable		 6dwnA-3fedA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 ASP A 220
TYR A 317
GLY A 300
VAL A 165
 None
 1.05A 6giqL-3fedA:
1.1
6giqP-3fedA:
undetectable
6giqT-3fedA:
undetectable		 6giqL-3fedA:
21.47
6giqP-3fedA:
14.43
6giqT-3fedA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		6 / 11 ASP A 475
SER A 486
TYR A 527
VAL A 566
ALA A 438
VAL A 454
 None
 1.31A 6hu9A-3fedA:
5.3
6hu9E-3fedA:
0.0
6hu9I-3fedA:
undetectable		 6hu9A-3fedA:
21.65
6hu9E-3fedA:
13.97
6hu9I-3fedA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		6 / 10 ASP A 475
SER A 486
TYR A 527
VAL A 566
ALA A 438
VAL A 454
 None
 1.31A 6hu9L-3fedA:
undetectable
6hu9P-3fedA:
undetectable
6hu9T-3fedA:
undetectable		 6hu9L-3fedA:
21.65
6hu9P-3fedA:
13.97
6hu9T-3fedA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 8 TYR A 699
PHE A 703
PHE A 176
SER A 686
 None
 1.25A 6huoC-3fedA:
3.9
6huoD-3fedA:
3.7		 6huoC-3fedA:
8.59
6huoD-3fedA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 HIS A 687
ARG A 180
ASP A 704
GLU A 706
 None
 1.35A 6mn4F-3fedA:
undetectable		 6mn4F-3fedA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 715
HIS A 608
GLU A 706
ASP A 704
 None
 1.28A 6mn4F-3fedA:
undetectable		 6mn4F-3fedA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.40A 6nmfN-3fedA:
undetectable
6nmfP-3fedA:
2.9		 6nmfN-3fedA:
21.70
6nmfP-3fedA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens) 		4 / 7 TRP A 424
ASP A  96
THR A 351
TRP A 411
 None
 1.44A 6nmpN-3fedA:
3.1
6nmpP-3fedA:
2.3		 6nmpN-3fedA:
21.70
6nmpP-3fedA:
16.94