SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 5 HIS A 276
GLU A 175
ALA A 271
HIS A 256
 None
 1.21A 1errA-3fefA:
undetectable
1errB-3fefA:
undetectable		 1errA-3fefA:
19.17
1errB-3fefA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 11 PHE A 419
GLU A 433
ASP A 411
GLY A 413
PHE A 416
 None
 1.40A 1hvyC-3fefA:
undetectable		 1hvyC-3fefA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 GLY A 355
ILE A 362
GLN A 354
VAL A 366
 None
 1.03A 1rs7B-3fefA:
undetectable		 1rs7B-3fefA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 ASN A 151
ARG A 275
HIS A 276
VAL A 115
 MG  A   1 ( 4.3A)
SO4  A   2 (-2.8A)
None
None
 1.38A 1wu8A-3fefA:
1.4
1wu8C-3fefA:
0.8		 1wu8A-3fefA:
23.21
1wu8C-3fefA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 5 GLU A 103
PRO A 102
ILE A 107
GLY A 106
 None
 1.04A 2qeuA-3fefA:
undetectable
2qeuC-3fefA:
undetectable		 2qeuA-3fefA:
17.07
2qeuC-3fefA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 SER A  31
THR A 313
ILE A  32
GLY A  21
 None
 0.95A 2v0mB-3fefA:
undetectable		 2v0mB-3fefA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 12 ALA A 233
GLU A 264
PHE A 263
PHE A 260
LEU A 182
 None
 1.22A 2w3mB-3fefA:
undetectable		 2w3mB-3fefA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 LEU A  30
ILE A 336
ILE A 167
LEU A  77
 None
 0.89A 2xkwB-3fefA:
undetectable		 2xkwB-3fefA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 HIS A 210
THR A 212
PHE A 211
LEU A 277
 MG  A   1 (-3.5A)
None
None
None
 1.13A 3bgdA-3fefA:
undetectable		 3bgdA-3fefA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 4 ARG A 302
ASP A  46
GLY A  17
THR A 150
 SO4  A   2 (-2.8A)
None
None
None
 1.47A 3k4vB-3fefA:
undetectable		 3k4vB-3fefA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 8 ASN A 209
THR A 212
HIS A 276
ASN A 151
 MG  A   1 ( 4.2A)
None
None
MG  A   1 ( 4.3A)
 1.03A 3kp2A-3fefA:
undetectable
3kp2B-3fefA:
undetectable		 3kp2A-3fefA:
15.71
3kp2B-3fefA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 12 ASP A 422
VAL A 403
GLY A 413
ALA A 432
LEU A 440
 None
 1.00A 3ku1H-3fefA:
4.4		 3ku1H-3fefA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 12 ILE A 269
PHE A 263
PHE A 231
ALA A 272
THR A 179
 None
 1.23A 3ndiA-3fefA:
2.2		 3ndiA-3fefA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 11 ARG A 220
SER A 218
ILE A 201
VAL A 187
VAL A 195
 None
 1.17A 3rf4A-3fefA:
undetectable
3rf4C-3fefA:
undetectable		 3rf4A-3fefA:
12.59
3rf4C-3fefA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 11 ARG A 220
SER A 218
ILE A 201
VAL A 187
VAL A 195
 None
 1.25A 3rf4A-3fefA:
undetectable
3rf4B-3fefA:
undetectable		 3rf4A-3fefA:
12.59
3rf4B-3fefA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 11 ARG A 220
SER A 218
ILE A 201
VAL A 187
VAL A 195
 None
 1.24A 3rf4B-3fefA:
undetectable
3rf4C-3fefA:
undetectable		 3rf4B-3fefA:
12.59
3rf4C-3fefA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 GLY A 329
GLU A 330
ASN A 348
GLU A 367
 None
 1.06A 3vywC-3fefA:
4.8		 3vywC-3fefA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 GLY A 355
ILE A 362
GLN A 354
VAL A 366
 None
 0.96A 4d39B-3fefA:
undetectable		 4d39B-3fefA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 PHE A 260
THR A 179
ILE A 269
PHE A 228
 None
 0.82A 4ejjA-3fefA:
undetectable		 4ejjA-3fefA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 GLY A 355
ILE A 362
GLN A 354
VAL A 366
 None
 1.01A 4kcnA-3fefA:
undetectable		 4kcnA-3fefA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		3 / 3 ILE A 222
MET A 186
ARG A 190
 None
 0.94A 4lnwA-3fefA:
undetectable		 4lnwA-3fefA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		3 / 3 ILE A 222
MET A 186
ARG A 190
 None
 0.93A 4lnxA-3fefA:
undetectable		 4lnxA-3fefA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 ILE A 120
ASP A 422
GLY A 112
HIS A 396
 None
 1.07A 4oltB-3fefA:
undetectable		 4oltB-3fefA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA701_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 5 TYR A 285
ASP A 261
TRP A 213
TYR A 266
 None
 1.40A 4p7nA-3fefA:
0.3		 4p7nA-3fefA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 TYR A 149
ALA A  13
ILE A 336
LEU A  26
 None
 1.05A 4uymA-3fefA:
undetectable		 4uymA-3fefA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 TYR A 149
ALA A  13
ILE A 336
LEU A  26
 None
 1.08A 4uymB-3fefA:
undetectable		 4uymB-3fefA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 SER A  91
LEU A  92
ASP A  93
LEU A  88
 None
 0.98A 4wozA-3fefA:
undetectable
4wozB-3fefA:
undetectable		 4wozA-3fefA:
22.75
4wozB-3fefA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 12 SER A 144
LEU A  77
ALA A 136
THR A 150
ALA A  13
 None
 1.26A 4x1kA-3fefA:
undetectable
4x1kB-3fefA:
2.7		 4x1kA-3fefA:
24.66
4x1kB-3fefA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		3 / 3 VAL A 111
THR A 297
ARG A 275
 None
SO4  A   2 ( 4.7A)
SO4  A   2 (-2.8A)
 0.67A 5b2sB-3fefA:
undetectable		 5b2sB-3fefA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 ASP A  98
ARG A 122
GLY A 123
THR A 150
 None
 0.93A 5btaA-3fefA:
undetectable
5btaC-3fefA:
undetectable
5btaD-3fefA:
undetectable		 5btaA-3fefA:
23.18
5btaC-3fefA:
23.18
5btaD-3fefA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 ASP A  98
ARG A 122
GLY A 123
THR A 150
 None
 0.99A 5btfA-3fefA:
undetectable
5btfB-3fefA:
undetectable
5btfC-3fefA:
undetectable		 5btfA-3fefA:
23.18
5btfB-3fefA:
21.54
5btfC-3fefA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 7 GLU A 199
GLY A 329
GLY A 332
ALA A 327
 None
 0.87A 5e26C-3fefA:
1.5
5e26D-3fefA:
1.6		 5e26C-3fefA:
20.68
5e26D-3fefA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		4 / 6 CYH A 105
LEU A 435
HIS A 100
LEU A 101
 None
 1.10A 5hpuC-3fefA:
undetectable
5hpuD-3fefA:
undetectable		 5hpuC-3fefA:
4.73
5hpuD-3fefA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 10 GLY A 116
GLU A 279
VAL A 111
THR A 114
ASN A 151
 None
None
None
None
MG  A   1 ( 4.3A)
 1.25A 6exiA-3fefA:
3.5		 6exiA-3fefA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E
(Bacillus
subtilis) 		5 / 10 GLY A 116
GLU A 279
VAL A 111
THR A 114
ASN A 151
 None
None
None
None
MG  A   1 ( 4.3A)
 1.23A 6exiB-3fefA:
4.0		 6exiB-3fefA:
13.57